OSIP339391

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463705

CAS#: 748136-54-1

Description: OSIP339391 is a A2BAR antagonist.

Chemical Structure

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OSIP339391
CAS# 748136-54-1
Instruction

Theoretical Analysis

MedKoo Cat#: 463705
Name: OSIP339391
CAS#: 748136-54-1
Chemical Formula: C30H35N7O2
Exact Mass: 525.29
Molecular Weight: 525.657
Elemental Analysis: C, 68.55; H, 6.71; N, 18.65; O, 6.09

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: OSIP339391; OSIP 339391; OSIP-339391; UCS15A; UCS 15A; UCS-15A;

IUPAC/Chemical Name: N-(2-((2-phenyl-6-(4-(3-phenylpropyl)piperazine-1-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)acetamide

InChi Key: MIUCZFWBCFZKEU-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H35N7O2/c1-22(38)31-14-15-32-28-25-21-26(33-29(25)35-27(34-28)24-12-6-3-7-13-24)30(39)37-19-17-36(18-20-37)16-8-11-23-9-4-2-5-10-23/h2-7,9-10,12-13,21H,8,11,14-20H2,1H3,(H,31,38)(H2,32,33,34,35)

SMILES Code: CC(NCCNC1=C2C(NC(C(N3CCN(CCCC4=CC=CC=C4)CC3)=O)=C2)=NC(C5=CC=CC=C5)=N1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 525.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ortore G, Martinelli A. A2B receptor ligands: past, present and future trends. Curr Top Med Chem. 2010;10(9):923-40. doi: 10.2174/156802610791268747. PMID: 20370659.

2: Kalla RV, Zablocki J, Tabrizi MA, Baraldi PG. Recent developments in A2B adenosine receptor ligands. Handb Exp Pharmacol. 2009;(193):99-122. doi: 10.1007/978-3-540-89615-9_4. PMID: 19639280.

3: Stewart M, Steinig AG, Ma C, Song JP, McKibben B, Castelhano AL, MacLennan SJ. [3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors. Biochem Pharmacol. 2004 Jul 15;68(2):305-12. doi: 10.1016/j.bcp.2004.03.026. PMID: 15194002.

4: Beukers MW, Meurs I, Ijzerman AP. Structure-affinity relationships of adenosine A2B receptor ligands. Med Res Rev. 2006 Sep;26(5):667-98. doi: 10.1002/med.20069. PMID: 16847822.

5: Mansourian M, Madadkar-Sobhani A, Mahnam K, Fassihi A, Saghaie L. Characterization of adenosine receptor in its native environment: insights from molecular dynamics simulations of palmitoylated/glycosylated, membrane- integrated human A(2B) adenosine receptor. J Mol Model. 2012 Sep;18(9):4309-24. doi: 10.1007/s00894-012-1427-y. Epub 2012 May 9. PMID: 22570080.

6: Gessi S, Varani K, Merighi S, Leung E, Mac Lennan S, Baraldi PG, Borea PA. Novel selective antagonist radioligands for the pharmacological study of A(2B) adenosine receptors. Purinergic Signal. 2006 Nov;2(4):583-8. doi: 10.1007/s11302-006-9019-x. Epub 2006 Jul 8. PMID: 18404460; PMCID: PMC2096665.