Quinclorac
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463344

CAS#: 84087-01-4

Description: Quinclorac is a postemergence herbicide, used for the control of broadleaf weeds, especially white clover (Trifolium repens L.) and Veronica filiformis.

Chemical Structure

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Quinclorac
CAS# 84087-01-4
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 463344
Name: Quinclorac
CAS#: 84087-01-4
Chemical Formula: C10H5Cl2NO2
Exact Mass: 240.97
Molecular Weight: 242.055
Elemental Analysis: C, 49.62; H, 2.08; Cl, 29.29; N, 5.79; O, 13.22

Price and Availability

Size Price Availability Quantity
10mg USD -2 2 Weeks
25mg USD -2 2 Weeks
50mg USD -2 2 Weeks
100mg USD -2 2 Weeks
500mg USD -2 2 Weeks
1g USD -2 2 Weeks
2g USD -2 2 Weeks
5g USD -2 2 Weeks
250mg USD 250 2 Weeks
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Synonym: Quinclorac; Quinclorac tech; Quinclorac-tech;

IUPAC/Chemical Name: 3,7-dichloroquinoline-8-carboxylic acid

InChi Key: FFSSWMQPCJRCRV-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H5Cl2NO2/c11-6-3-5-1-2-7(12)8(10(14)15)9(5)13-4-6/h1-4H,(H,14,15)

SMILES Code: OC(c(c(Cl)cc1)c2c1cc(Cl)cn2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: TBD

Shelf Life: >3 years if stored properly

Drug Formulation: TBD

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Quinclorac induces oxidative stress due to free radical generation and changes in the antioxidant defense system.
In vitro activity: Naegleria fowleri and Balamuthia mandrillaris are pathogenic free-living amoebae that infect the central nervous system with over 95% mortality rates. This study evaluated a range of compounds, including quinclorac, against N. fowleri and B. mandrillaris. All compounds tested showed minimal human cell cytotoxicity as determined by lactate dehydrogenase release. Further research is needed to determine the potential of these repurposed compounds and to determine the intranasal route of delivery to treat these infections. Reference: Antibiotics (Basel). 2022 May 31;11(6):749. https://pubmed.ncbi.nlm.nih.gov/35740156/
In vivo activity: Tadpoles of Rhinella icterica were collected in a pesticide-free place, acclimated in the laboratory and exposed to three herbicides (atrazine, glyphosate, quinclorac, and their mixtures). Only 2% mortality was observed, but there were significant variations observed for markers of oxidative balance and body condition across experimental groups. The mixture of the three herbicides proved to be most harmful, which points to the need for more restrictive laws for the use of mixed herbicides. Reference: Environ Toxicol Pharmacol. 2023 May 4;100:104145. https://pubmed.ncbi.nlm.nih.gov/37149011/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
TBD 0.0 0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 242.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Siddiqui R, Mungroo MR, Anuar TS, Alharbi AM, Alfahemi H, Elmoselhi AB, Khan NA. Antiamoebic Properties of Laboratory and Clinically Used Drugs against Naegleria fowleri and Balamuthia mandrillaris. Antibiotics (Basel). 2022 May 31;11(6):749. doi: 10.3390/antibiotics11060749. PMID: 35740156; PMCID: PMC9220410. 2. Dahabiyeh LA, Bustanji Y, Taha MO. The herbicide quinclorac as potent lipase inhibitor: Discovery via virtual screening and in vitro/in vivo validation. Chem Biol Drug Des. 2019 May;93(5):787-797. doi: 10.1111/cbdd.13463. Epub 2019 Jan 11. PMID: 30570819. 3. Reichert LMM, de Oliveira DR, Papaleo JL, Valgas AAN, Oliveira GT. Impact of commercial formulations of herbicides alone and in mixtures on the antioxidant system and body condition parameters in tadpoles of Rhinella icterica (Spix 1824). Environ Toxicol Pharmacol. 2023 May 4;100:104145. doi: 10.1016/j.etap.2023.104145. Epub ahead of print. PMID: 37149011. 4. Cai X, Chen J, Wang X, Gao H, Xiang B, Dong L. Mefenacet resistance in multiple herbicide-resistant Echinochloa crus-galli L. populations. Pestic Biochem Physiol. 2022 Mar;182:105038. doi: 10.1016/j.pestbp.2022.105038. Epub 2022 Jan 21. PMID: 35249656.
In vitro protocol: 1. Siddiqui R, Mungroo MR, Anuar TS, Alharbi AM, Alfahemi H, Elmoselhi AB, Khan NA. Antiamoebic Properties of Laboratory and Clinically Used Drugs against Naegleria fowleri and Balamuthia mandrillaris. Antibiotics (Basel). 2022 May 31;11(6):749. doi: 10.3390/antibiotics11060749. PMID: 35740156; PMCID: PMC9220410. 2. Dahabiyeh LA, Bustanji Y, Taha MO. The herbicide quinclorac as potent lipase inhibitor: Discovery via virtual screening and in vitro/in vivo validation. Chem Biol Drug Des. 2019 May;93(5):787-797. doi: 10.1111/cbdd.13463. Epub 2019 Jan 11. PMID: 30570819.
In vivo protocol: 1. Reichert LMM, de Oliveira DR, Papaleo JL, Valgas AAN, Oliveira GT. Impact of commercial formulations of herbicides alone and in mixtures on the antioxidant system and body condition parameters in tadpoles of Rhinella icterica (Spix 1824). Environ Toxicol Pharmacol. 2023 May 4;100:104145. doi: 10.1016/j.etap.2023.104145. Epub ahead of print. PMID: 37149011. 2. Cai X, Chen J, Wang X, Gao H, Xiang B, Dong L. Mefenacet resistance in multiple herbicide-resistant Echinochloa crus-galli L. populations. Pestic Biochem Physiol. 2022 Mar;182:105038. doi: 10.1016/j.pestbp.2022.105038. Epub 2022 Jan 21. PMID: 35249656.

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1: Yang L, Deng Y, Gong D, Luo H, Zhou X, Jiang F. Effects of low molecular weight organic acids on adsorption of quinclorac by sepiolite. Environ Sci Pollut Res Int. 2020 Nov 4. doi: 10.1007/s11356-020-11405-8. Epub ahead of print. PMID: 33146822.

2: Mendes KF, Maset BA, Mielke KC, Sousa RN, Martins BAB, Tornisielo VL. Phytoremediation of quinclorac and tebuthiuron-polluted soil by green manure plants. Int J Phytoremediation. 2020 Oct 1:1-8. doi: 10.1080/15226514.2020.1825329. Epub ahead of print. PMID: 33000969.

3: Zhang R, Bai X, Shao J, Chen A, Wu H, Luo S. Effects of zero-valent iron nanoparticles and quinclorac coexposure on the growth and antioxidant system of rice (Oryza sativa L.). Ecotoxicol Environ Saf. 2020 Oct 15;203:111054. doi: 10.1016/j.ecoenv.2020.111054. Epub 2020 Jul 28. PMID: 32888616.

4: Cao JJ, Peng Q, Yang X, Yang Q, Bai LY, Li YF, Zhang ZC, Gu T. 外源茉莉酸甲酯诱导抗性与敏感稗草对二氯喹啉酸抗性的差异及机理 [Differences in exogenous methyl jasmonate- induced quinclorac resistance between resistant and sensitive barnyardgrass and the underlying mechanism]. Ying Yong Sheng Tai Xue Bao. 2020 Jul;31(7):2293-2298. Chinese. doi: 10.13287/j.1001-9332.202007.038. PMID: 32715694.

5: Fang J, He Z, Liu T, Li J, Dong L. A novel mutation Asp-2078-Glu in ACCase confers resistance to ACCase herbicides in barnyardgrass (Echinochloa crus- galli). Pestic Biochem Physiol. 2020 Sep;168:104634. doi: 10.1016/j.pestbp.2020.104634. Epub 2020 Jun 18. PMID: 32711768.

6: Bergmann FB, do Amaral AMB, Volcan MV, Leitemperger JW, Zanella R, Prestes OD, Clasen B, Guadagnin DL, Loro VL. Organic and conventional agriculture: Conventional rice farming causes biochemical changes in Astyanax lacustris. Sci Total Environ. 2020 Nov 20;744:140820. doi: 10.1016/j.scitotenv.2020.140820. Epub 2020 Jul 9. PMID: 32711309.

7: Yang X, Han H, Cao J, Li Y, Yu Q, Powles SB. Exploring quinclorac resistance mechanisms in Echinochloa crus-pavonis from China. Pest Manag Sci. 2020 Jul 11. doi: 10.1002/ps.6007. Epub ahead of print. PMID: 32652760.

8: Jiménez-López J, Llorent-Martínez EJ, Ruiz-Medina A. Sensitive fluorometric determination of quinclorac residues in rice. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2020 Jun;37(6):983-988. doi: 10.1080/19440049.2020.1740336. Epub 2020 Mar 20. PMID: 32196433.

9: Wang J, Zhang C, Shi Y, Long M, Islam F, Yang C, Yang S, He Y, Zhou W. Evaluation of quinclorac toxicity and alleviation by salicylic acid in rice seedlings using ground-based visible/near-infrared hyperspectral imaging. Plant Methods. 2020 Mar 5;16:30. doi: 10.1186/s13007-020-00576-7. PMID: 32165910; PMCID: PMC7059665.

10: Zia Ul Haq M, Zhang Z, Wei J, Qiang S. Ethylene Biosynthesis Inhibition Combined with Cyanide Degradation Confer Resistance to Quinclorac in Echinochloa crus-galli var. mitis. Int J Mol Sci. 2020 Feb 25;21(5):1573. doi: 10.3390/ijms21051573. PMID: 32106618; PMCID: PMC7084851.

11: Zhou N, Zu J, Yang L, Shu X, Guan J, Deng Y, Gong D, Ding C, Zhong ME. Cobalt (0/II) incorporated N-doped porous carbon as effective heterogeneous peroxymonosulfate catalyst for quinclorac degradation. J Colloid Interface Sci. 2020 Mar 15;563:197-206. doi: 10.1016/j.jcis.2019.12.067. Epub 2019 Dec 17. PMID: 31874307.

12: Severo ES, Marins AT, Cerezer C, Costa D, Nunes M, Prestes OD, Zanella R, Loro VL. Ecological risk of pesticide contamination in a Brazilian river located near a rural area: A study of biomarkers using zebrafish embryos. Ecotoxicol Environ Saf. 2020 Mar 1;190:110071. doi: 10.1016/j.ecoenv.2019.110071. Epub 2019 Dec 13. PMID: 31841896.

13: Yang Y, Pratap Singh R, Song D, Chen Q, Zheng X, Zhang C, Zhang M, Li Y. Synergistic effect of Pseudomonas putida II-2 and Achromobacter sp. QC36 for the effective biodegradation of the herbicide quinclorac. Ecotoxicol Environ Saf. 2020 Jan 30;188:109826. doi: 10.1016/j.ecoenv.2019.109826. Epub 2019 Nov 13. PMID: 31732271.

14: Chayapakdee P, Sunohara Y, Endo M, Yamaguchi T, Fan L, Uchino A, Matsumoto H, Iwakami S. Quinclorac resistance in Echinochloa phyllopogon is associated with reduced ethylene synthesis rather than enhanced cyanide detoxification by β-cyanoalanine synthase. Pest Manag Sci. 2020 Apr;76(4):1195-1204. doi: 10.1002/ps.5660. Epub 2019 Nov 27. PMID: 31659851.

15: Fathy M, Mohamed IA, Farghal AIA, Temerak SAH, Sayed AEH. Hemotoxic effects of some herbicides on juvenile of Nile tilapia Oreochromis niloticus. Environ Sci Pollut Res Int. 2019 Oct;26(30):30857-30865. doi: 10.1007/s11356-019-06280-x. Epub 2019 Aug 24. Erratum in: Environ Sci Pollut Res Int. 2020 Jan;27(3):3541. PMID: 31446602.

16: Fang J, Zhang Y, Liu T, Yan B, Li J, Dong L. Target-Site and Metabolic Resistance Mechanisms to Penoxsulam in Barnyardgrass (Echinochloa crus- galli (L.) P. Beauv). J Agric Food Chem. 2019 Jul 24;67(29):8085-8095. doi: 10.1021/acs.jafc.9b01641. Epub 2019 Jul 16. PMID: 31265279.

17: Wu LM, Fang Y, Yang HN, Bai LY. Effects of drought-stress on seed germination and growth physiology of quinclorac-resistant Echinochloa crusgalli. PLoS One. 2019 Apr 4;14(4):e0214480. doi: 10.1371/journal.pone.0214480. PMID: 30947307; PMCID: PMC6448836.

18: Zainul R, Abd Azis N, Md Isa I, Hashim N, Ahmad MS, Saidin MI, Mukdasai S. Zinc/Aluminium⁻Quinclorac Layered Nanocomposite Modified Multi-Walled Carbon Nanotube Paste Electrode for Electrochemical Determination of Bisphenol A. Sensors (Basel). 2019 Feb 22;19(4):941. doi: 10.3390/s19040941. PMID: 30813385; PMCID: PMC6413131.

19: Dahabiyeh LA, Bustanji Y, Taha MO. The herbicide quinclorac as potent lipase inhibitor: Discovery via virtual screening and in vitro/in vivo validation. Chem Biol Drug Des. 2019 May;93(5):787-797. doi: 10.1111/cbdd.13463. Epub 2019 Jan 11. PMID: 30570819.

20: Gao Y, Pan X, Sun X, Li J, Dong L. Is the protection of photosynthesis related to the mechanism of quinclorac resistance in Echinochloa crus-galli var. zelayensis? Gene. 2019 Jan 30;683:133-148. doi: 10.1016/j.gene.2018.10.022. Epub 2018 Oct 11. PMID: 30316919.