Thiorphan disulfide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574906

CAS#: 123658-06-0

Description: Thiorphan disulfide is an impurity of Racecadotril -- an antidiarrheal and enkephalinase inhibitor that reduces the amount of water and electrolytes absorbed into the intestine.

Chemical Structure

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Thiorphan disulfide
CAS# 123658-06-0
Instruction

Theoretical Analysis

MedKoo Cat#: 574906
Name: Thiorphan disulfide
CAS#: 123658-06-0
Chemical Formula: C24H28N2O6S2
Exact Mass: 504.14
Molecular Weight: 504.620
Elemental Analysis: C, 57.13; H, 5.59; N, 5.55; O, 19.02; S, 12.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 76721-89-6 (free)  

Synonym: Thiorphan disulfide

IUPAC/Chemical Name: N,N'-[Dithiobis[1-oxo-2-(phenylmethyl)-3,1-propanediyl]]bis-glycine

InChi Key: QGHBJQCOYUZBCX-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H28N2O6S2/c27-21(28)13-25-23(31)19(11-17-7-3-1-4-8-17)15-33-34-16-20(24(32)26-14-22(29)30)12-18-9-5-2-6-10-18/h1-10,19-20H,11-16H2,(H,25,31)(H,26,32)(H,27,28)(H,29,30)

SMILES Code: O=C(NCC(O)=O)C(CC1=CC=CC=C1)CSSCC(CC2=CC=CC=C2)C(NCC(O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 504.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Whyteside, A.R., and Turner, A.J. Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 582(16), 2382-2386 (2008).

2. Inguimbert, N., Coric, P., Poras, H., et al. Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP). J. Med. Chem. 45(7), 1477-1486 (2002).

3. Krassói, I., Pataricza, J., and Papp, J.G. Thiorphan enhances bradykinin-induced vascular relaxation in hypoxic/hyperkalaemic porcine coronary artery. J. Pharm. Pharmacol. 55(3), 339-345 (2003).

4. Chicau-Chover, M., Dubrasquet, M., Chariot, J., et al. Thiorphan and acetorphan inhibit gastric secretion by a central, non-opioid mechanism in the rat. Eur. J. Pharmacol. 154(3), 247-254 (1998).

5. Mouri, A., Zou, L.B., Iwata, N., et al. Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid β and impairment of learning and memory. Behav. Brain Res. 168(1), 83-91 (2006).