QZ59S-SSS

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MedKoo CAT#: 574857

CAS#: 945624-90-8

Description: QZ59S-SSS acts as a potential inhibitor of human P-glycoprotein and may be used to improve the efficacy of cancer chemotherapy.

Chemical Structure

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QZ59S-SSS
CAS# 945624-90-8
Instruction

Theoretical Analysis

MedKoo Cat#: 574857
Name: QZ59S-SSS
CAS#: 945624-90-8
Chemical Formula: C24H30N6O3S3
Exact Mass: 546.15
Molecular Weight: 546.720
Elemental Analysis: C, 52.73; H, 5.53; N, 15.37; O, 8.78; S, 17.59

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: QZ59S-SSS

IUPAC/Chemical Name: 6,13,20-Trithia-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.15,8.112,15]tetracosa-5(24),7,12(23),14,19(22),21-hexaene-2,9,16-trione, 4,11,18-tris(1-methylethyl)-, (4S,11S,18S)-

InChi Key: MCTYQNKZLHHNCP-BZSNNMDCSA-N

InChi Code: InChI=1S/C24H30N6O3S3/c1-10(2)16-22-25-14(7-34-22)20(32)29-18(12(5)6)24-27-15(9-36-24)21(33)30-17(11(3)4)23-26-13(8-35-23)19(31)28-16/h7-12,16-18H,1-6H3,(H,28,31)(H,29,32)(H,30,33)/t16-,17-,18-/m0/s1

SMILES Code: O=C(N[C@@H](C(C)C)C1=NC(C(N[C@@H](C(C)C)C2=NC(C(N[C@H]3C(C)C)=O)=CS2)=O)=CS1)C4=CSC3=N4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 546.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Chufan EE, Kapoor K, Sim HM, Singh S, Talele TT, Durell SR, Ambudkar SV. Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1). PLoS One. 2013 Dec 5;8(12):e82463. doi: 10.1371/journal.pone.0082463. PMID: 24349290; PMCID: PMC3857843.

2. Singh S, Prasad NR, Kapoor K, Chufan EE, Patel BA, Ambudkar SV, Talele TT. Design, synthesis, and biological evaluation of (S)-valine thiazole-derived cyclic and noncyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1). Chembiochem. 2014 Jan 3;15(1):157-69. doi: 10.1002/cbic.201300565. Epub 2013 Nov 29. PMID: 24288265; PMCID: PMC3905599.