SNT-207858
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MedKoo CAT#: 462412

CAS#: 1104080-42-3

Description: SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist.

Chemical Structure

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SNT-207858
CAS# 1104080-42-3
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 462412
Name: SNT-207858
CAS#: 1104080-42-3
Chemical Formula: C32H45Cl4N5O3
Exact Mass: 0.00
Molecular Weight: 689.540
Elemental Analysis: C, 55.74; H, 6.58; Cl, 20.56; N, 10.16; O, 6.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1104662-66-9  

Synonym: SNT-207858 HCl; SNT 207858 HCl; SNT207858 HCl; SNT-207858 hydrochloride; SNT 207858 hydrochloride; SNT207858 hydrochloride

IUPAC/Chemical Name: N-((R)-3-(2,4-dichlorophenyl)-1-oxo-1-(4-(3-((R)-2-(pyrrolidin-1-yl)butoxy)pyridin-2-yl)piperidin-1-yl)propan-2-yl)pyrrolidine-1-carboxamide dihydrochloride

InChi Key: DFRHMBGAOYBWHK-VXGCXGCYSA-N

InChi Code: InChI=1S/C32H43Cl2N5O3.2ClH/c1-2-26(37-14-3-4-15-37)22-42-29-8-7-13-35-30(29)23-11-18-38(19-12-23)31(40)28(36-32(41)39-16-5-6-17-39)20-24-9-10-25(33)21-27(24)34;;/h7-10,13,21,23,26,28H,2-6,11-12,14-20,22H2,1H3,(H,36,41);2*1H/t26-,28-;;/m1../s1

SMILES Code: [H]Cl.O=C(N1CCCC1)N[C@H](CC2=CC=C(Cl)C=C2Cl)C(N3CCC(C4=NC=CC=C4OC[C@H](N5CCCC5)CC)CC3)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Biological target: SNT-207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
In vitro activity: To be determined
In vivo activity: SNT-207858 is a potential therapeutic treatment for cachexia patients. In this study, SNT-207707 and SNT-207858 were found to distinctly increase food intake in healthy mice. In a mouse model of adenocarcinoma, repeated oral administration of both compounds almost completely prevented tumor induced weight loss and diminished loss of lean body mass and fat mass. **Note: this article mistakenly labels “SNT207858” as “SNT209858” in the abstract. Reference: PLoS One. 2009;4(3):e4774. https://pubmed.ncbi.nlm.nih.gov/19295909/

Preparing Stock Solutions

The following data is based on the product molecular weight 689.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Weyermann P, Dallmann R, Magyar J, Anklin C, Hufschmid M, Dubach-Powell J, Courdier-Fruh I, Henneböhle M, Nordhoff S, Mondadori C. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. doi: 10.1371/journal.pone.0004774. Epub 2009 Mar 19. PMID: 19295909; PMCID: PMC2654097.
In vitro protocol: To be determined
In vivo protocol: 1. Weyermann P, Dallmann R, Magyar J, Anklin C, Hufschmid M, Dubach-Powell J, Courdier-Fruh I, Henneböhle M, Nordhoff S, Mondadori C. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. doi: 10.1371/journal.pone.0004774. Epub 2009 Mar 19. PMID: 19295909; PMCID: PMC2654097.

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1: Weyermann P, Dallmann R, Magyar J, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. doi:10.1371/journal.pone.0004774