ZD-4190
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462402

CAS#: 413599-62-9

Description: ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer.


Chemical Structure

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ZD-4190
CAS# 413599-62-9

Theoretical Analysis

MedKoo Cat#: 462402
Name: ZD-4190
CAS#: 413599-62-9
Chemical Formula: C19H16BrFN6O2
Exact Mass: 458.0502
Molecular Weight: 459.2794
Elemental Analysis: C, 49.69; H, 3.51; Br, 17.40; F, 4.14; N, 18.30; O, 6.97

Price and Availability

Size Price Availability Quantity
5.0mg USD 830.0 2 Weeks
10.0mg USD 940.0 2 Weeks
50.0mg USD 3400.0 2 Weeks
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Synonym: ZD-4190; ZD4190; ZD 4190

IUPAC/Chemical Name: 7-(2-(1H-1,2,3-triazol-1-yl)ethoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine

InChi Key: YBTGTVGEKMZEQX-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H16BrFN6O2/c1-28-17-9-13-16(10-18(17)29-7-6-27-5-4-24-26-27)22-11-23-19(13)25-15-3-2-12(20)8-14(15)21/h2-5,8-11H,6-7H2,1H3,(H,22,23,25)

SMILES Code: BrC(C=C1F)=CC=C1NC2=C3C(C=C(OCCN4C=CN=N4)C(OC)=C3)=NC=N2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 459.2794 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yang M, Gao H, Yan Y, et al. PET imaging of early response to the tyrosine kinase inhibitor ZD4190. Eur J Nucl Med Mol Imaging. 2011;38(7):1237-1247. doi:10.1007/s00259-011-1742-z

2: Gaballah K, Oakley R, Hills A, Ryan A, Partridge M. The antiangiogenic agent ZD4190 prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues. Br J Cancer. 2009;101(3):418-423. doi:10.1038/sj.bjc.6605092

3: Checkley D, Tessier JJ, Wedge SR, et al. Dynamic contrast-enhanced MRI of vascular changes induced by the VEGF-signalling inhibitor ZD4190 in human tumour xenografts. Magn Reson Imaging. 2003;21(5):475-482. doi:10.1016/s0730-725x(02)00644-6

ZD-4190

5.0mg / USD 830.0