SC 3123

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 535074

CAS#: 36576-29-1

Description: SC 3123 is a bioactive chemical.

Chemical Structure

img
SC 3123
CAS# 36576-29-1
Instruction

Theoretical Analysis

MedKoo Cat#: 535074
Name: SC 3123
CAS#: 36576-29-1
Chemical Formula: C21H27N3O4
Exact Mass: 385.20
Molecular Weight: 385.464
Elemental Analysis: C, 65.44; H, 7.06; N, 10.90; O, 16.60

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SC 3123; SC-3123; SC3123

IUPAC/Chemical Name: N-(2-o-Methoxyphenoxyethyl)-6,7-dimethoxy-3,4-dihydro-2-(1H)-isoquinoline carboxamidine

InChi Key: FOFOIHRXOXJRCM-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H27N3O4/c1-25-17-6-4-5-7-18(17)28-11-9-23-21(22)24-10-8-15-12-19(26-2)20(27-3)13-16(15)14-24/h4-7,12-13H,8-11,14H2,1-3H3,(H2,22,23)

SMILES Code: N=C(N1CC2=C(C=C(OC)C(OC)=C2)CC1)NCCOC3=CC=CC=C3OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 385.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Ambler GK, Twine CP. Graft type for femoro-popliteal bypass surgery. Cochrane Database Syst Rev. 2018 Feb 11;2(2):CD001487. doi: 10.1002/14651858.CD001487.pub3. PMID: 29429146; PMCID: PMC6491197.


2: Krell RW, D'Angelica MI. Treatment sequencing for simultaneous colorectal liver metastases. J Surg Oncol. 2019 Apr;119(5):583-593. doi: 10.1002/jso.25424. Epub 2019 Feb 28. PMID: 30816577.


3: Eyre R, Alférez DG, Santiago-Gómez A, Spence K, McConnell JC, Hart C, Simões BM, Lefley D, Tulotta C, Storer J, Gurney A, Clarke N, Brown M, Howell SJ, Sims AH, Farnie G, Ottewell PD, Clarke RB. Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling. Nat Commun. 2019 Nov 1;10(1):5016. doi: 10.1038/s41467-019-12807-0. PMID: 31676788; PMCID: PMC6825219.


4: Ferrini R, Miragoli G, Santarelli G. Pharmacological actions of N-(2-o-methoxyphenoxyethyl)-6,7-dimethoxy-3,4-dihydro-2-(1H)-isoquinoline carboxamidine hydrobromide (SC-3123). Boll Chim Farm. 1972 Jun;111(6):353-65. PMID: 4403255.


5: Vegas-Revenga N, Calvo-Río V, Mesquida M, Adán A, Hernández MV, Beltrán E, Valls Pascual E, Díaz-Valle D, Díaz-Cordovés G, Hernandez-Garfella M, Martínez- Costa L, Calvo I, Atanes A, Linares LF, Modesto C, González-Vela C, Demetrio- Pablo R, Aurrecoechea E, Cordero M, Domínguez-Casas LC, Atienza-Mateo B, Martín- Varillas JL, Loricera J, Palmou-Fontana N, Hernández JL, González-Gay MA, Blanco R. Anti-IL6-Receptor Tocilizumab in Refractory and Noninfectious Uveitic Cystoid Macular Edema: Multicenter Study of 25 Patients. Am J Ophthalmol. 2019 Apr;200:85-94. doi: 10.1016/j.ajo.2018.12.019. Epub 2019 Jan 17. PMID: 30660771.


6: Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO. Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission. EMBO J. 2018 Aug 1;37(15):e98044. doi: 10.15252/embj.201798044. Epub 2018 Jun 27. PMID: 29950309; PMCID: PMC6068464.


7: Delhorme JB, Severac F, Averous G, Glehen O, Passot G, Bakrin N, Marchal F, Pocard M, Lo Dico R, Eveno C, Carrere S, Sgarbura O, Quenet F, Ferron G, Goéré D, Brigand C; French National Network of Peritoneal Surface Malignancies (RENAPE). Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendicular and extra-appendicular origin. Br J Surg. 2018 May;105(6):668-676. doi: 10.1002/bjs.10716. Epub 2018 Feb 7. PMID: 29412465.


8: Rodríguez-Enríquez M, Bennasar-Veny M, Leiva A, Yañez AM. Alcohol and Tobacco Consumption, Personality, and Cybervictimization among Adolescents. Int J Environ Res Public Health. 2019 Aug 28;16(17):3123. doi: 10.3390/ijerph16173123. PMID: 31466216; PMCID: PMC6747350.


9: Safanelli J, Vieira LGDR, Araujo T, Manchope LFS, Kuhlhoff MHR, Nagel V, Conforto AB, Silva GS, Mazin S, Magalhães PSC, Cabral NL. The cost of stroke in a public hospital in Brazil: a one-year prospective study. Arq Neuropsiquiatr. 2019 Jul 15;77(6):404-411. doi: 10.1590/0004-282X20190059. PMID: 31314842.


10: Pon TK, Wessel N, Cagonot V, Delmonte R, Roach D, Finta L. Utilization of venous thromboembolism prophylaxis in American hospitalized pregnant women undergoing cesarean section. Int J Clin Pharm. 2019 Feb;41(1):264-271. doi: 10.1007/s11096-018-00779-y. Epub 2019 Jan 19. PMID: 30661217.


11: Fader KA, Nault R, Zhang C, Kumagai K, Harkema JR, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism. Sci Rep. 2017 Jul 19;7(1):5921. doi: 10.1038/s41598-017-05656-8. PMID: 28725001; PMCID: PMC5517430.


12: Swe PM, Zakrzewski M, Waddell R, Sriprakash KS, Fischer K. High-throughput metagenome analysis of the Sarcoptes scabiei internal microbiota and in-situ identification of intestinal Streptomyces sp. Sci Rep. 2019 Aug 13;9(1):11744. doi: 10.1038/s41598-019-47892-0. PMID: 31409870; PMCID: PMC6692375.


13: Tao A, Chen G, Deng Y, Xu R. Accuracy of Transcranial Sonography of the Substantia Nigra for Detection of Parkinson's Disease: A Systematic Review and Meta-analysis. Ultrasound Med Biol. 2019 Mar;45(3):628-641. doi: 10.1016/j.ultrasmedbio.2018.11.010. Epub 2019 Jan 3. PMID: 30612821.


14: Finch SC, Munday JS, Sprosen JM, Bhattarai S. Toxicity Studies of Chanoclavine in Mice. Toxins (Basel). 2019 May 2;11(5):249. doi: 10.3390/toxins11050249. PMID: 31052510; PMCID: PMC6563201.


15: Squeglia F, Ruggiero A, Berisio R. Collagen degradation in tuberculosis pathogenesis: the biochemical consequences of hosting an undesired guest. Biochem J. 2018 Oct 11;475(19):3123-3140. doi: 10.1042/BCJ20180482. PMID: 30315001.


16: Palmer M, Tarver J, Paris Perez J, Cawthorne T, Romeo R, Stringer D, Hallett V, Mueller J, Breese L, Hollett M, Beresford B, Knapp M, Slonims V, Pickles A, Simonoff E, Scott S, Charman T. A novel group parenting intervention to reduce emotional and behavioural difficulties in young autistic children: protocol for the Autism Spectrum Treatment and Resilience pilot randomised controlled trial. BMJ Open. 2019 Jun 27;9(6):e029959. doi: 10.1136/bmjopen-2019-029959. PMID: 31248932; PMCID: PMC6597639.


17: McIsaac M, Kaban G, Clay A, Berry W, Prasad B. Long-Term Impact of Bariatric Surgery on Renal Outcomes at a Community-Based Publicly Funded Bariatric Program: The Regina Bariatric Study. Can J Kidney Health Dis. 2019 Oct 24;6:2054358119884903. doi: 10.1177/2054358119884903. PMID: 31695923; PMCID: PMC6820179.


18: Munday R, Reeve J. Risk assessment of shellfish toxins. Toxins (Basel). 2013 Nov 11;5(11):2109-37. doi: 10.3390/toxins5112109. PMID: 24226039; PMCID: PMC3847717.


19: Maliszewska J, Marcinkowska S, Nowakowska A, Kletkiewicz H, Rogalska J. Altered heat nociception in cockroach Periplaneta americana L. exposed to capsaicin. PLoS One. 2018 Mar 8;13(3):e0194109. doi: 10.1371/journal.pone.0194109. PMID: 29518142; PMCID: PMC5843330.


20: Auerbach D, Yan F, Zhang Y, Müller R. Characterization of an Unusual Glycerate Esterification Process in Vioprolide Biosynthesis. ACS Chem Biol. 2018 Nov 16;13(11):3123-3130. doi: 10.1021/acschembio.8b00826. Epub 2018 Oct 22. PMID: 30286293.