WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462157
CAS#: 230961-21-4
Description: UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor.
MedKoo Cat#: 462157
Name: UK 370106
CAS#: 230961-21-4
Chemical Formula: C35H44N2O5
Exact Mass: 572.325
Molecular Weight: 572.746
Elemental Analysis: C, 73.40; H, 7.74; N, 4.89; O, 13.97
Synonym: UK 370106; UK-370106; UK370106
IUPAC/Chemical Name: (R)-3-(((S)-1-(((S)-2-methoxy-1-phenylethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)-6-(2-methyl-[1,1'-biphenyl]-4-yl)hexanoic acid
InChi Key: NSMABJUGSNPHMN-BHYWQNONSA-N
InChi Code: InChI=1S/C35H44N2O5/c1-24-21-25(19-20-29(24)26-14-8-6-9-15-26)13-12-18-28(22-31(38)39)33(40)37-32(35(2,3)4)34(41)36-30(23-42-5)27-16-10-7-11-17-27/h6-11,14-17,19-21,28,30,32H,12-13,18,22-23H2,1-5H3,(H,36,41)(H,37,40)(H,38,39)/t28-,30-,32-/m1/s1
SMILES Code: O=C([C@H](CCCC1=CC=C(C2=CC=CC=C2)C(C)=C1)CC(O)=O)N[C@@H](C(C)(C)C)C(N[C@H](COC)C3=CC=CC=C3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 572.746 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Ågren MS, Schnabel R, Christensen LH, Mirastschijski U. Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo. Eur J Cell Biol. 2015;94(1):12‐21. doi:10.1016/j.ejcb.2014.10.001
