UK 370106

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462157

CAS#: 230961-21-4

Description: UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor.

Chemical Structure

UK 370106
CAS# 230961-21-4

Theoretical Analysis

MedKoo Cat#: 462157
Name: UK 370106
CAS#: 230961-21-4
Chemical Formula: C35H44N2O5
Exact Mass: 572.33
Molecular Weight: 572.746
Elemental Analysis: C, 73.40; H, 7.74; N, 4.89; O, 13.97

Price and Availability

Size Price Availability Quantity
10mg USD 430 2 Weeks
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Synonym: UK 370106; UK-370106; UK370106

IUPAC/Chemical Name: (R)-3-(((S)-1-(((S)-2-methoxy-1-phenylethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)-6-(2-methyl-[1,1'-biphenyl]-4-yl)hexanoic acid


InChi Code: InChI=1S/C35H44N2O5/c1-24-21-25(19-20-29(24)26-14-8-6-9-15-26)13-12-18-28(22-31(38)39)33(40)37-32(35(2,3)4)34(41)36-30(23-42-5)27-16-10-7-11-17-27/h6-11,14-17,19-21,28,30,32H,12-13,18,22-23H2,1-5H3,(H,36,41)(H,37,40)(H,38,39)/t28-,30-,32-/m1/s1

SMILES Code: O=C([C@H](CCCC1=CC=C(C2=CC=CC=C2)C(C)=C1)CC(O)=O)N[C@@H](C(C)(C)C)C(N[C@H](COC)C3=CC=CC=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 572.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ågren MS, Schnabel R, Christensen LH, Mirastschijski U. Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo. Eur J Cell Biol. 2015;94(1):12‐21. doi:10.1016/j.ejcb.2014.10.001