Sulisobenzone
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 534787

CAS#: 4065-45-6

Description: Sulisobenzone is a skin / eye irritant.


Chemical Structure

img
Sulisobenzone
CAS# 4065-45-6

Theoretical Analysis

MedKoo Cat#: 534787
Name: Sulisobenzone
CAS#: 4065-45-6
Chemical Formula: C14H12O6S
Exact Mass: 308.04
Molecular Weight: 308.304
Elemental Analysis: C, 54.54; H, 3.92; O, 31.14; S, 10.40

Price and Availability

Size Price Availability Quantity
10g USD 290 2 Weeks
Bulk inquiry

Synonym: Sulisobenzone

IUPAC/Chemical Name: 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid

InChi Key: CXVGEDCSTKKODG-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H12O6S/c1-20-12-8-11(15)10(7-13(12)21(17,18)19)14(16)9-5-3-2-4-6-9/h2-8,15H,1H3,(H,17,18,19)

SMILES Code: O=C(C1=CC=CC=C1)C2=CC(S(=O)(O)=O)=C(OC)C=C2O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 308.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Beel R, Lütke Eversloh C, Ternes TA. Biotransformation of the UV-filter sulisobenzone: challenges for the identification of transformation products. Environ Sci Technol. 2013 Jul 2;47(13):6819-28. doi: 10.1021/es400451w. Epub 2013 Jun 19. PMID: 23815618.


2: Baer RL, Ramsay DL. Polyvalent light sensitivity (persistent light reactivity?); allergic contact sensitivity to sulisobenzone. Arch Dermatol. 1971 Oct;104(4):446-8. doi: 10.1001/archderm.104.4.446. PMID: 5114428.


3: Kurul E, Hekimoğlu S. Skin permeation of two different benzophenone derivatives from various vehicles. Int J Cosmet Sci. 2001 Aug;23(4):211-8. doi: 10.1046/j.1467-2494.2001.00089.x. PMID: 18498461.


4: Sherwood VF, Kennedy S, Zhang H, Purser GH, Sheaff RJ. Altered UV absorbance and cytotoxicity of chlorinated sunscreen agents. Cutan Ocul Toxicol. 2012 Dec;31(4):273-9. doi: 10.3109/15569527.2011.647181. Epub 2012 Jan 18. PMID: 22257218.


5: Chisvert A, Pascual-Martí MC, Salvador A. Determination of UV-filters in sunscreens by HPLC. Fresenius J Anal Chem. 2001 Apr;369(7-8):638-41. doi: 10.1007/s002160100701. PMID: 11371063.


6: Bratkovics S, Wirth E, Sapozhnikova Y, Pennington P, Sanger D. Baseline monitoring of organic sunscreen compounds along South Carolina's coastal marine environment. Mar Pollut Bull. 2015 Dec 15;101(1):370-377. doi: 10.1016/j.marpolbul.2015.10.015. Epub 2015 Nov 2. PMID: 26541983.


7: Yong T, Li D, Li M, Liang D, Diao X, Deng C, Chen S, Xie Y, Chen D, Zuo D. Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD. Molecules. 2018 Oct 17;23(10):2671. doi: 10.3390/molecules23102671. PMID: 30336599; PMCID: PMC6222621.


8: Yang P, Kong D, Ji Y, Lu J, Yin X, Zhou Q. Chlorination and chloramination of benzophenone-3 and benzophenone-4 UV filters. Ecotoxicol Environ Saf. 2018 Nov 15;163:528-535. doi: 10.1016/j.ecoenv.2018.07.111. Epub 2018 Aug 1. PMID: 30077149.


9: He T, Tsui MMP, Tan CJ, Ng KY, Guo FW, Wang LH, Chen TH, Fan TY, Lam PKS, Murphy MB. Comparative toxicities of four benzophenone ultraviolet filters to two life stages of two coral species. Sci Total Environ. 2019 Feb 15;651(Pt 2):2391-2399. doi: 10.1016/j.scitotenv.2018.10.148. Epub 2018 Oct 11. PMID: 30336428.


10: Chang Y, Bai Y, Huo Y, Qu J. Benzophenone-4 Promotes the Growth of a Pseudomonas sp. and Biogenic Oxidation of Mn(II). Environ Sci Technol. 2018 Feb 6;52(3):1262-1269. doi: 10.1021/acs.est.7b05014. Epub 2018 Jan 26. PMID: 29336564.


11: Huang Y, Luo L, Ma XY, Wang XC. Effect of elevated benzophenone-4 (BP4) concentration on Chlorella vulgaris growth and cellular metabolisms. Environ Sci Pollut Res Int. 2018 Nov;25(32):32549-32561. doi: 10.1007/s11356-018-3171-z. Epub 2018 Sep 21. PMID: 30238265.


12: Seto Y, Ohtake H, Kato M, Onoue S. Phototoxic Risk Assessments on Benzophenone Derivatives: Photobiochemical Assessments and Dermal Cassette- Dosing Pharmacokinetic Study. J Pharmacol Exp Ther. 2015 Aug;354(2):195-202. doi: 10.1124/jpet.115.223644. Epub 2015 May 27. PMID: 26016852.


13: Kung TA, Lee SH, Yang TC, Wang WH. Survey of selected personal care products in surface water of coral reefs in Kenting National Park, Taiwan. Sci Total Environ. 2018 Sep 1;635:1302-1307. doi: 10.1016/j.scitotenv.2018.04.115. Epub 2018 Apr 24. PMID: 29710583.


14: Ignasiak MT, Houée-Levin C, Kciuk G, Marciniak B, Pedzinski T. A reevaluation of the photolytic properties of 2-hydroxybenzophenone-based UV sunscreens: are chemical sunscreens inoffensive? Chemphyschem. 2015 Feb 23;16(3):628-33. doi: 10.1002/cphc.201402703. Epub 2015 Jan 7. PMID: 25581220.


15: Soto-Vázquez L, Rolón-Delgado F, Rivera K, Cotto MC, Ducongé J, Morant C, Pinilla S, Márquez-Linares FM. Catalytic use of TiO2 nanowires in the photodegradation of Benzophenone-4 as an active ingredient in sunscreens. J Environ Manage. 2019 Oct 1;247:822-828. doi: 10.1016/j.jenvman.2019.07.005. Epub 2019 Jul 10. PMID: 31301647.


16: Walter JF, DeQuoy PR. The hairless mouse as a model for evaluating sunscreens. Prevention of ultraviolet B inhibition of epidermal DNA synthesis. Arch Dermatol. 1980 Apr;116(4):419-21. PMID: 7369771.


17: Jia X, Jin J, Gao R, Feng T, Huang Y, Zhou Q, Li A. Degradation of benzophenone-4 in a UV/chlorine disinfection process: Mechanism and toxicity evaluation. Chemosphere. 2019 May;222:494-502. doi: 10.1016/j.chemosphere.2019.01.186. Epub 2019 Jan 31. PMID: 30721807.


18: Matthieu L, Meuleman L, Van Hecke E, Blondeel A, Dezfoulian B, Constandt L, Goossens A. Contact and photocontact allergy to ketoprofen. The Belgian experience. Contact Dermatitis. 2004 Apr;50(4):238-41. doi: 10.1111/j.0105-1873.2004.00323.x. PMID: 15186381.


19: Jarratt M, Hill M, Smiles K. Topical protection against long-wave ultraviolet A. J Am Acad Dermatol. 1983 Sep;9(3):354-60. doi: 10.1016/s0190-9622(83)70141-6. PMID: 6605370.


20: Frikeche J, Couteau C, Roussakis C, Coiffard LJ. Research on the immunosuppressive activity of ingredients contained in sunscreens. Arch Dermatol Res. 2015 Apr;307(3):211-8. doi: 10.1007/s00403-014-1528-9. Epub 2015 Jan 4. PMID: 25556843.