Peimisine HCl
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MedKoo CAT#: 574166

CAS#: 900498-44-4 (HCl)

Description: Peimisine HCl is a steroidal alkaloid that inhibits lung acetylcholinesterase (AChE).

Chemical Structure

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Peimisine HCl
CAS# 900498-44-4 (HCl)
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 574166
Name: Peimisine HCl
CAS#: 900498-44-4 (HCl)
Chemical Formula: C27H42ClNO3
Exact Mass: 463.29
Molecular Weight: 464.087
Elemental Analysis: C, 69.88; H, 9.12; Cl, 7.64; N, 3.02; O, 10.34

Price and Availability

Size Price Availability Quantity
10mg USD 350 2 weeks
25mg USD 750 2 weeks
50mg USD 1350 2 weeks
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Related CAS #: 19773-24-1 (free base); 900498-44-4 (HCl)  

Synonym: Peimisine HCl, Peimisine Hydrochloride

IUPAC/Chemical Name: (2'R,3S,3'R,3'aS,4aS,6'S,6aR,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',4a,5',6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-5(6H)-one, monohydrochloride

InChi Key: BVYFGCQMQQGAEY-MCZYSGEJSA-N

InChi Code: InChI=1S/C27H41NO3.ClH/c1-14-9-24-25(28-13-14)16(3)27(31-24)8-6-18-19(15(27)2)11-21-20(18)12-23(30)22-10-17(29)5-7-26(21,22)4;/h14,16-18,20-22,24-25,28-29H,5-13H2,1-4H3;1H/t14-,16+,17-,18+,20-,21-,22+,24+,25-,26+,27-;/m0./s1

SMILES Code: O=C1[C@@]2([H])C[C@@H](O)CC[C@]2(C)[C@]3([H])[C@@]([C@@]4([H])C(C3)=C(C)[C@@]5(O[C@@](C[C@H](C)CN6)([H])[C@]6([H])[C@H]5C)CC4)([H])C1.Cl

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Peimisine (Ebeiensine) hydrochloride is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.0 34.48
Ethanol 1.0 2.15

Preparing Stock Solutions

The following data is based on the product molecular weight 464.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1. An, J.-J., Zhou, J.-L., Li, H.-J., et al. Puqienine E: An angiotensin converting enzyme inhibitory steroidal alkaloid from Fritillaria puqiensis. Fitoterapia 81(3), 149-152 (2010).