WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574098
Description: YW1159 is an inhibitor of Wnt signaling.
MedKoo Cat#: 574098
Chemical Formula: C19H14FN5O
Exact Mass: 347.1182
Molecular Weight: 347.35
Elemental Analysis: C, 65.70; H, 4.06; F, 5.47; N, 20.16; O, 4.61
Synonym: Compound 3d, YW1159, YW 1159, YW-1159
IUPAC/Chemical Name: 1-(2-fluorophenyl)-5-methyl-N-2-quinolinyl-1H-1,2,3-triazole-4-carboxamide
InChi Key: PNGUNLPOXKPCPK-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H14FN5O/c1-12-18(23-24-25(12)16-9-5-3-7-14(16)20)19(26)22-17-11-10-13-6-2-4-8-15(13)21-17/h2-11H,1H3,(H,21,22,26)
SMILES Code: O=C(C1=C(C)N(C2=C(F)C=CC=C2)N=N1)NC3=CC=C(C=CC=C4)C4=N3
Appearance: A crystalline solid
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 347.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Xue, F., and Shu, Y. Wnt signaling pathway inhibitors for treatments of disease. WO 2017/151786 Al, (2017).
2. Obianom, O.N., Ai, Y., Li, Y., et al. Triazole-based inhibitors of the Wnt/β-catenin signaling pathway improve glucose and lipid metabolism in diet-induced obese mice. J. Med. Chem. 62(2), 727-741 (2019).
λmax: 257, 318, 332 nm