Quinestradol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585070

CAS#: 1169-79-5

Description: Quinestradol is a synthetic estrogen and estrogen ether.

Chemical Structure

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Quinestradol
CAS# 1169-79-5
Instruction

Theoretical Analysis

MedKoo Cat#: 585070
Name: Quinestradol
CAS#: 1169-79-5
Chemical Formula: C23H32O3
Exact Mass: 356.24
Molecular Weight: 356.506
Elemental Analysis: C, 77.49; H, 9.05; O, 13.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Quinestradol; Colpovis; Colpovister; Pentovis

IUPAC/Chemical Name: 3-(Cyclopentyloxy)estra-1,3,5(10)-triene-16alpha,17beta-diol

InChi Key: ODYKCPYPRCJXLY-PZORDLPLSA-N

InChi Code: InChI=1S/C23H32O3/c1-23-11-10-18-17-9-7-16(26-15-4-2-3-5-15)12-14(17)6-8-19(18)20(23)13-21(24)22(23)25/h7,9,12,15,18-22,24-25H,2-6,8,10-11,13H2,1H3/t18-,19-,20+,21-,22+,23+/m1/s1

SMILES Code: C[C@@]12[C@@H](O)[C@H](O)C[C@@]1([H])[C@]3([H])CCC4=C(C=CC(OC5CCCC5)=C4)[C@@]3([H])CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 356.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Liu Q, Qin J, Chen Q, Wang D, Shi D. Fertility control of Rattus nitidus using quinestrol: effects on reproductive organs and social behavior. Integr Zool. 2013 Apr;8 Suppl 1:9-17. doi: 10.1111/j.1749-4877.2012.00296.x. Epub 2012 Oct 31. Erratum in: Integr Zool. 2016 Mar;11(2):173. PubMed PMID: 23621467.

2: Katzenellenbogen BS. Biology and receptor interactions of estriol and estriol derivatives in vitro and in vivo. J Steroid Biochem. 1984 Apr;20(4B):1033-7. PubMed PMID: 6727348.

3: Bruni G, Rossi GL, Celasco G, Falconi G. [Effects of estriol and quinestradol administered to pregnant rats on the fetal sex differentiation]. Ann Ostet Ginecol Med Perinat. 1975 Mar-Apr;96(2):83-90. Italian. PubMed PMID: 1220592.

4: Judge TG. The use of quinestradol in elderly incontinent women, a preliminary report. Gerontol Clin (Basel). 1969;11(3):159-64. PubMed PMID: 4890404.

5: Beaton D. A comparative trial of quinestradol and ethinyl oestradiol. Br J Clin Pract. 1967 May;21(5):241-3. PubMed PMID: 6046407.

6: Eckstein P, Greig M, Butt WR. The induction of withdrawal bleeding with quinestradol (pentovis) in spayed monkeys, and some observations on its excretion and that of oestriol in the urine. J Endocrinol. 1967 Mar;37(3):239-44. PubMed PMID: 4960138.