LA2

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565787

CAS#: N/A

Description: LA2 is a novel pan-activator for all ampk isoforms

Chemical Structure

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LA2
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 565787
Name: LA2
CAS#: N/A
Chemical Formula: C31H30ClN5O5
Exact Mass: 587.19
Molecular Weight: 588.061
Elemental Analysis: C, 63.32; H, 5.14; Cl, 6.03; N, 11.91; O, 13.60

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: LA2; LA 2; LA-2

IUPAC/Chemical Name: (3R,3aR,6R,6aR)-6-((6-chloro-5-(4'-(4-(2-hydroxy-2-methylpropyl)-1H-pyrazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol

InChi Key: QDOCWPJIJINJJM-CDRKEARJSA-N

InChi Code: InChI=1S/C31H30ClN5O5/c1-31(2,39)12-17-13-33-37(14-17)21-9-7-19(8-10-21)18-3-5-20(6-4-18)26-22(32)11-23-29(35-26)36-30(34-23)42-25-16-41-27-24(38)15-40-28(25)27/h3-11,13-14,24-25,27-28,38-39H,12,15-16H2,1-2H3,(H,34,35,36)/t24-,25-,27-,28-/m1/s1

SMILES Code: O[C@H]1[C@](OC[C@H]2OC3=NC4=NC(C5=CC=C(C6=CC=C(N7N=CC(CC(C)(O)C)=C7)C=C6)C=C5)=C(Cl)C=C4N3)([H])[C@]2([H])OC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 588.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yamada M, Muto Y, Kurihara H, Slanina Z, Suzuki M, Maeda Y, Rubin Y, Olmstead MM, Balch AL, Nagase S, Lu X, Akasaka T. Regioselective cage opening of La2 @D2 (10611)-C72 with 5,6-diphenyl-3-(2-pyridyl)-1,2,4-triazine. Angew Chem Int Ed Engl. 2015 Feb 9;54(7):2232-5. doi: 10.1002/anie.201410012. Epub 2014 Dec 23. PubMed PMID: 25536953.

2: Anissimova S, Parshall D, Gu GD, Marty K, Lumsden MD, Chi S, Fernandez-Baca JA, Abernathy DL, Lamago D, Tranquada JM, Reznik D. Direct observation of dynamic charge stripes in La2-xSrxNiO4. Nat Commun. 2014 Mar 17;5:3467. doi: 10.1038/ncomms4467. PubMed PMID: 24632780.

3: Sung KD, Lee TK, Jung JH. Intriguing photo-control of exchange bias in BiFeO3/La2/3Sr1/3MnO3 thin films on SrTiO3 substrates. Nanoscale Res Lett. 2015 Mar 12;10:125. doi: 10.1186/s11671-015-0824-4. eCollection 2015. PubMed PMID: 25852417; PubMed Central PMCID: PMC4385218.

4: Rivas-Murias B, Lucas I, Jiménez-Cavero P, Magén C, Morellón L, Rivadulla F. Independent Control of the Magnetization in Ferromagnetic La2/3Sr1/3MnO3/SrTiO3/LaCoO3 Heterostructures Achieved by Epitaxial Lattice Mismatch. Nano Lett. 2016 Mar 9;16(3):1736-40. doi: 10.1021/acs.nanolett.5b04657. Epub 2016 Feb 2. PubMed PMID: 26822394.

5: Bao L, Chen M, Pan C, Yamaguchi T, Kato T, Olmstead MM, Balch AL, Akasaka T, Lu X. Crystallographic Evidence for Direct Metal-Metal Bonding in a Stable Open-Shell La2 @Ih -C80 Derivative. Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4242-6. doi: 10.1002/anie.201511930. Epub 2016 Feb 25. PubMed PMID: 26918907.

6: Haruta N, Sato T, Tanaka K. Reactivity of endohedral metallofullerene la2@c80 in nucleophilic and electrophilic attacks: vibronic coupling density approach. J Org Chem. 2015 Jan 2;80(1):141-7. doi: 10.1021/jo502208t. Epub 2014 Dec 1. PubMed PMID: 25389657.

7: Yi D, Liu J, Hsu SL, Zhang L, Choi Y, Kim JW, Chen Z, Clarkson JD, Serrao CR, Arenholz E, Ryan PJ, Xu H, Birgeneau RJ, Ramesh R. Atomic-scale control of magnetic anisotropy via novel spin-orbit coupling effect in La2/3Sr1/3MnO3/SrIrO3 superlattices. Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6397-402. doi: 10.1073/pnas.1524689113. Epub 2016 May 19. PubMed PMID: 27199482; PubMed Central PMCID: PMC4988617.

8: Zhou W, Xiong Y, Zhang Z, Wang D, Tan W, Cao Q, Qian Z, Du Y. Multilevel Resistance Switching Memory in La2/3Ba1/3MnO3/0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 (011) Heterostructure by Combined Straintronics-Spintronics. ACS Appl Mater Interfaces. 2016 Mar 2;8(8):5424-31. doi: 10.1021/acsami.5b11392. Epub 2016 Feb 16. PubMed PMID: 26846130.

9: Liu X, Hou W, Yang X, Shen Q. Pure-phase La2(WO4)3:Eu3+ nanocrystals and spindle-like NaLa(WO4)2:Yb3+/Er3+ nano/microcrystals: selective synthesis, morphologies and photoluminescent properties. Dalton Trans. 2013 Aug 28;42(32):11445-54. doi: 10.1039/c3dt50562f. Epub 2013 Jul 3. PubMed PMID: 23824277.

10: Yao L, Majumdar S, Äkäslompolo L, Inkinen S, Qin QH, van Dijken S. Electron-beam-induced Perovskite-Brownmillerite-Perovskite structural phase transitions in epitaxial La2/3Sr1/3MnO3 films. Adv Mater. 2014 May;26(18):2789-93. doi: 10.1002/adma.201305656. Epub 2014 Feb 19. PubMed PMID: 24554587.

11: Li ZW, Drees Y, Kuo CY, Guo H, Ricci A, Lamago D, Sobolev O, Rütt U, Gutowski O, Pi TW, Piovano A, Schmidt W, Mogare K, Hu Z, Tjeng LH, Komarek AC. Incommensurate spin correlations in highly oxidized cobaltates La2-xSrxCoO4. Sci Rep. 2016 Apr 27;6:25117. doi: 10.1038/srep25117. PubMed PMID: 27117928; PubMed Central PMCID: PMC4846828.

12: Xiong YQ, Zhou WP, Li Q, Cao QQ, Tang T, Wang DH, Du YW. Electric field modification of magnetism in Au/La2/3Ba1/3MnO3/Pt device. Sci Rep. 2015 Aug 4;5:12766. doi: 10.1038/srep12766. PubMed PMID: 26238932; PubMed Central PMCID: PMC4523834.

13: Suzuki M, Mizorogi N, Yang T, Uhlik F, Slanina Z, Zhao X, Yamada M, Maeda Y, Hasegawa T, Nagase S, Lu X, Akasaka T. La2@C(s)(17,490)-C76: a new non-IPR dimetallic metallofullerene featuring unexpectedly weak metal-pentalene interactions. Chemistry. 2013 Dec 9;19(50):17125-30. doi: 10.1002/chem.201302821. Epub 2013 Nov 6. PubMed PMID: 24307369.

14: Suzuki K, Koyanagi M, Yamashita H. Genetic characterization and specific detection of beer-spoilage Lactobacillus sp. LA2 and related strains. J Appl Microbiol. 2004;96(4):677-83. PubMed PMID: 15012805.

15: Phatak R, Gupta SK, Maheshwari P, Das A, Sali SK. Crystal structure of Ba(2)(La(0.727)Ba(0.182)M(0.091))MO(6) (M = Nb, Sb, Bi): symmetry nuance identified in photoluminescence and IR spectroscopy studies. Dalton Trans. 2017 Jan 31;46(5):1694-1703. doi: 10.1039/c6dt04124h. PubMed PMID: 28102388.

16: Shandilya S, Kurt Yilmaz N, Sadowski A, Monir E, Schiller ZA, Thomas WD Jr, Klempner MS, Schiffer CA, Wang Y. Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions. J Mol Recognit. 2017 May;30(5). doi: 10.1002/jmr.2595. Epub 2016 Nov 16. PubMed PMID: 27859766; PubMed Central PMCID: PMC5383521.

17: Feng N, Mi W, Wang X. First principles prediction of interfacial magnetoelectric coupling in tetragonal La2/3Sr1/3MnO3/BiFeO3 multiferroic superlattices. Phys Chem Chem Phys. 2015 May 28;17(20):13647-53. doi: 10.1039/c5cp01857a. PubMed PMID: 25940540.

18: Ravella UK, Liu J, Corbel G, Skinner SJ, Lacorre P. Cationic Intermixing and Reactivity at the La2 Mo2 O9 /La0.8 Sr0.2 MnO3-δ Solid Oxide Fuel Cell Electrolyte-Cathode Interface. ChemSusChem. 2016 Aug 23;9(16):2182-92. doi: 10.1002/cssc.201600516. Epub 2016 Aug 1. PubMed PMID: 27478975.

19: Nishibori E, Takata M, Sakata M, Taninaka A, Shinohara H. Pentagonal-dodecahedral la2 charge density in [80-ih ]fullerene: la2 @c80. Angew Chem Int Ed Engl. 2001;40(16):2998-9. doi: 10.1002/1521-3773(20010817)40:16<2998::AID-ANIE2998>3.0.CO;2-4. PubMed PMID: 12203628.

20: Cao B, Wakahara T, Tsuchiya T, Kondo M, Maeda Y, Aminur Rahman GM, Akasaka T, Kobayashi K, Nagase S, Yamamoto K. Isolation, characterization, and theoretical study of La2@C78. J Am Chem Soc. 2004 Aug 4;126(30):9164-5. PubMed PMID: 15281789.