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MedKoo CAT#: 565782

CAS#: 1241390-29-3

Description: This product is removed

Chemical Structure

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This product is removed
CAS# 1241390-29-3
Instruction

Theoretical Analysis

MedKoo Cat#: 565782
Name: This product is removed
CAS#: 1241390-29-3
Chemical Formula: C12H10F2N2O2
Exact Mass: 252.07
Molecular Weight: 252.221
Elemental Analysis: C, 57.15; H, 4.00; F, 15.06; N, 11.11; O, 12.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym:

IUPAC/Chemical Name: (Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one

InChi Key: ZDDIJYXDUBFLID-YHYXMXQVSA-N

InChi Code: InChI=1S/C12H10F2N2O2/c1-6-15-10(12(18)16(6)2)5-7-3-8(13)11(17)9(14)4-7/h3-5,17H,1-2H3/b10-5-

SMILES Code: O=C1N(C)C(C)=N/C1=C\C2=CC(F)=C(O)C(F)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 252.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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7: Dou J, Vorobieva AA, Sheffler W, Doyle LA, Park H, Bick MJ, Mao B, Foight GW, Lee MY, Gagnon LA, Carter L, Sankaran B, Ovchinnikov S, Marcos E, Huang PS, Vaughan JC, Stoddard BL, Baker D. De novo design of a fluorescence-activating β-barrel. Nature. 2018 Sep;561(7724):485-491. doi: 10.1038/s41586-018-0509-0. Epub 2018 Sep 12. PubMed PMID: 30209393; PubMed Central PMCID: PMC6275156.

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9: Kellenberger CA, Hallberg ZF, Hammond MC. Live Cell Imaging Using Riboswitch-Spinach tRNA Fusions as Metabolite-Sensing Fluorescent Biosensors. Methods Mol Biol. 2015;1316:87-103. doi: 10.1007/978-1-4939-2730-2_8. PubMed PMID: 25967055.

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12: Song W, Strack RL, Svensen N, Jaffrey SR. Plug-and-play fluorophores extend the spectral properties of Spinach. J Am Chem Soc. 2014 Jan 29;136(4):1198-201. doi: 10.1021/ja410819x. Epub 2014 Jan 18. PubMed PMID: 24393009; PubMed Central PMCID: PMC3929357.

13: Ketterer S, Fuchs D, Weber W, Meier M. Systematic reconstruction of binding and stability landscapes of the fluorogenic aptamer spinach. Nucleic Acids Res. 2015 Oct 30;43(19):9564-72. doi: 10.1093/nar/gkv944. Epub 2015 Sep 22. PubMed PMID: 26400180; PubMed Central PMCID: PMC4627091.

14: Burch BD, Garrido C, Margolis DM. Detection of human immunodeficiency virus RNAs in living cells using Spinach RNA aptamers. Virus Res. 2017 Jan 15;228:141-146. doi: 10.1016/j.virusres.2016.11.031. Epub 2016 Nov 30. PubMed PMID: 27914932; PubMed Central PMCID: PMC5195857.

15: Sharma S, Zaveri A, Visweswariah SS, Krishnan Y. A fluorescent nucleic acid nanodevice quantitatively images elevated cyclic adenosine monophosphate in membrane-bound compartments. Small. 2014 Nov 12;10(21):4276-80. doi: 10.1002/smll.201400833. Epub 2014 Jul 14. PubMed PMID: 25044725.

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17: Autour A, Westhof E, Ryckelynck M. iSpinach: a fluorogenic RNA aptamer optimized for in vitro applications. Nucleic Acids Res. 2016 Apr 7;44(6):2491-500. doi: 10.1093/nar/gkw083. Epub 2016 Mar 1. PubMed PMID: 26932363; PubMed Central PMCID: PMC4824111.

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19: Kikuchi N, Kolpashchikov DM. Split Spinach Aptamer for Highly Selective Recognition of DNA and RNA at Ambient Temperatures. Chembiochem. 2016 Sep 2;17(17):1589-92. doi: 10.1002/cbic.201600323. Epub 2016 Jul 15. PubMed PMID: 27305425; PubMed Central PMCID: PMC5198575.

20: Zhou Y, Shen S, Lau C, Lu J. A conformational switch-based fluorescent biosensor for homogeneous detection of telomerase activity. Talanta. 2019 Jul 1;199:21-26. doi: 10.1016/j.talanta.2019.02.018. Epub 2019 Feb 4. PubMed PMID: 30952248.