Fce 28260

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585012

CAS#: 155651-56-2

Description: Fce 28260 is a 5 alpha-reductase inhibitor.

Chemical Structure

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Fce 28260
CAS# 155651-56-2
Instruction

Theoretical Analysis

MedKoo Cat#: 585012
Name: Fce 28260
CAS#: 155651-56-2
Chemical Formula: C28H35F3N2O2
Exact Mass: 488.27
Molecular Weight: 488.595
Elemental Analysis: C, 68.83; H, 7.22; F, 11.67; N, 5.73; O, 6.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Fce 28260; Fce28260; Fce-28260

IUPAC/Chemical Name: (22RS-N-1,1,1-Trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide

InChi Key: FAIZUAWLKOHMOP-ZOIXLQFFSA-N

InChi Code: InChI=1S/C28H35F3N2O2/c1-25-15-13-20-18(9-12-22-26(20,2)16-14-23(34)32-22)19(25)10-11-21(25)24(35)33-27(3,28(29,30)31)17-7-5-4-6-8-17/h4-8,14,16,18-22H,9-13,15H2,1-3H3,(H,32,34)(H,33,35)/t18-,19-,20-,21+,22+,25-,26+,27?/m0/s1

SMILES Code: C[C@@]12[C@@H](C(NC(C)(C3=CC=CC=C3)C(F)(F)F)=O)CC[C@@]1([H])[C@]4([H])CC[C@@]5([H])NC(C=C[C@]5(C)[C@@]4([H])CC2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 488.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Di Salle E, Briatico G, Giudici D, Ornati G, Zaccheo T, Buzzetti F, Nesi M, Panzeri A. Novel aromatase and 5 alpha-reductase inhibitors. J Steroid Biochem Mol Biol. 1994 Jun;49(4-6):289-94. PubMed PMID: 8043491.

2: Giudici D, Briatico G, Cominato C, Zaccheo T, Iehlè C, Nesi M, Panzeri A, di Salle E. FCE 28260, a new 5 alpha-reductase inhibitor: in vitro and in vivo effects. J Steroid Biochem Mol Biol. 1996 Jun;58(3):299-305. PubMed PMID: 8836165.

3: Rosen GJ, Wade J. The role of 5alpha-reductase activity in sexual behaviors of the green anole lizard. Physiol Behav. 2000 Jun 1-15;69(4-5):487-98. PubMed PMID: 10913788.

4: Zaccheo T, Giudici D, Panzeri A, di Salle E. Effect of the 5 alpha-reductase inhibitor PNU 156765, alone or in combination with flutamide, in the Dunning R3327 prostatic carcinoma model in rats. Chemotherapy. 1998 Jul-Aug;44(4):284-92. PubMed PMID: 9681205.

5: Dalla Valle L, Toffolo V, Vianello S, Belvedere P, Colombo L. Expression of cytochrome P450c17 and other steroid-converting enzymes in the rat kidney throughout the life-span. J Steroid Biochem Mol Biol. 2004 Jun;91(1-2):49-58. PubMed PMID: 15261307.