Ortho-AP1867
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MedKoo CAT#: 565348

CAS#: 2230613-03-1

Description: Ortho-AP1867 is an isomer of AP1867. In Ortho-AP1867, the carboxymethoxy group is in ortho-position. AP1867, also known as dTAG acid, is a precursor for the dTAG system which pairs a novel degrader of FKBP12(F36V) with expression of FKBP12(F36V) in-frame with a protein of interest. It shows superior antiproliferative effect of pan-BET bromodomain degradation over selective BRD4 degradation. AP1867 characterizes immediate effects of KRAS(G12V) loss on proteomic signaling, and demonstrates rapid degradation in vivo.

Chemical Structure

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Ortho-AP1867
CAS# 2230613-03-1
Instruction

Theoretical Analysis

MedKoo Cat#: 565348
Name: Ortho-AP1867
CAS#: 2230613-03-1
Chemical Formula: C38H47NO11
Exact Mass: 693.31
Molecular Weight: 693.790
Elemental Analysis: C, 65.79; H, 6.83; N, 2.02; O, 25.37

Price and Availability

Size Price Availability Quantity
5mg USD 950 2 Weeks
10mg USD 1650 2 Weeks
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Synonym: OrthoAP1867; Ortho AP1867; Ortho-AP1867

IUPAC/Chemical Name: 2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid

InChi Key: UYXSZUBFOQLRNQ-BTIIJPOSSA-N

InChi Code: InChI=1S/C38H47NO11/c1-7-26(25-21-33(46-4)36(48-6)34(22-25)47-5)37(42)39-19-11-10-13-28(39)38(43)50-30(27-12-8-9-14-29(27)49-23-35(40)41)17-15-24-16-18-31(44-2)32(20-24)45-3/h8-9,12,14,16,18,20-22,26,28,30H,7,10-11,13,15,17,19,23H2,1-6H3,(H,40,41)/t26-,28-,30+/m0/s1

SMILES Code: O=C(O)COC1=CC=CC=C1[C@H](OC([C@H]2N(C([C@H](C3=CC(OC)=C(OC)C(OC)=C3)CC)=O)CCCC2)=O)CCC4=CC=C(OC)C(OC)=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 693.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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