TT-10
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565341

CAS#: 2230640-94-3

Description: TT-10 is an activator of pro-proliferative YES-associated protein and transcriptional enhancer factor domain (YAP-TEAD) activities in cardiomyocytes, which promote cardiomyocyte proliferation and simultaneously exert antioxidant and antiapoptotic effects in vitro.

Chemical Structure

img
TT-10
CAS# 2230640-94-3
Instruction

Theoretical Analysis

MedKoo Cat#: 565341
Name: TT-10
CAS#: 2230640-94-3
Chemical Formula: C11H10FN3OS2
Exact Mass: 283.02
Molecular Weight: 283.340
Elemental Analysis: C, 46.63; H, 3.56; F, 6.71; N, 14.83; O, 5.65; S, 22.63

Price and Availability

Size Price Availability Quantity
200mg USD -2 2 Weeks
500mg USD -2 2 Weeks
1g USD -2 2 Weeks
2g USD -2 2 Weeks
5mg USD 250 2 Weeks
10mg USD 450 2 Weeks
25mg USD 850 2 Weeks
50mg USD 1450 2 Weeks
100mg USD 2650 2 Weeks
Bulk inquiry

Synonym: TT10; TT 10; TT-10

IUPAC/Chemical Name: (2-(Allylamino)-4-aminothiazol-5-yl)(5-fluorothiophen-2-yl)methanone

InChi Key: GVYPHJQPOHDZEI-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H10FN3OS2/c1-2-5-14-11-15-10(13)9(18-11)8(16)6-3-4-7(12)17-6/h2-4H,1,5,13H2,(H,14,15)

SMILES Code: O=C(C1=C(N)N=C(NCC=C)S1)C2=CC=C(F)S2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 283.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I. Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury. JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653. doi: 10.1016/j.jacbts.2018.07.005. eCollection 2018 Oct. PubMed PMID: 30456335; PubMed Central PMCID: PMC6234526.

2: Ito M, Hara H, Takeda N, Naito AT, Nomura S, Kondo M, Hata Y, Uchiyama M, Morita H, Komuro I. Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2019 Mar;128:90-95. doi: 10.1016/j.yjmcc.2019.01.020. Epub 2019 Jan 23. PubMed PMID: 30684499.