Opc 8490

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584921

CAS#: 123941-50-4

Description: Opc 8490 is a positive inotropic agent.

Chemical Structure

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Opc 8490
CAS# 123941-50-4
Instruction

Theoretical Analysis

MedKoo Cat#: 584921
Name: Opc 8490
CAS#: 123941-50-4
Chemical Formula: C30H35N3O10
Exact Mass: 597.23
Molecular Weight: 597.621
Elemental Analysis: C, 60.29; H, 5.90; N, 7.03; O, 26.77

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Opc 8490; Opc-8490; Opc8490

IUPAC/Chemical Name: Piperazine, 1-(4-oxo-4-phenylbutyl)-4-((1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)carbonyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

InChi Key: ONELTIQETCJUSG-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H27N3O3.C6H8O7/c28-22(18-5-2-1-3-6-18)7-4-12-26-13-15-27(16-14-26)24(30)20-8-10-21-19(17-20)9-11-23(29)25-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h1-3,5-6,8,10,17H,4,7,9,11-16H2,(H,25,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

SMILES Code: O=C(N1CCN(CCCC(C2=CC=CC=C2)=O)CC1)C3=CC4=C(NC(CC4)=O)C=C3.O=C(CC(C(O)=O)(O)CC(O)=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 597.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Focaccio A, Peeters G, Movsesian M, Roden R, Eki Y, Krall J, Bristow MR. Mechanism of action of OPC-8490 in human ventricular myocardium. Circulation. 1996 Feb 15;93(4):817-25. PubMed PMID: 8641012.

2: Kurachi Y, Asano Y, Ito H, Sugimoto T. Voltage-dependent inhibition of the delayed outward potassium current by OPC-8490, a novel positive inotropic agent, in isolated atrial myocytes of guinea-pig heart. Naunyn Schmiedebergs Arch Pharmacol. 1990 Apr;341(4):324-30. PubMed PMID: 1692107.

3: Furukawa Y, Akahane K, Haniuda M, Chiba S. Positive inotropic and negative chronotropic effects of OPC-8490, a newly developed cardiotonic, in isolated, blood-perfused canine heart preparations. Jpn Heart J. 1989 May;30(3):387-98. PubMed PMID: 2552190.

4: Endoh M, Satoh H, Norota I, Hirano K, Hosokawa T. Subcellular mechanism of the positive inotropic effect of a new quinolinone derivative OPC-8490 on the dog ventricular myocardium. Heart Vessels. 1991;6(3):158-67. PubMed PMID: 1655692.

5: Momose Y, Sasayama S. Effect of OPC-8490 on the membrane potentials and membrane currents of single guinea-pig myocytes. Cardiovasc Drugs Ther. 1990 Jun;4(3):713-7. PubMed PMID: 1963791.

6: Kameyama T, Asanoi H, Ishizaka S, Nozawa T, Fujita M, Sasayama S. [End-systolic pressure-volume relationships obtained by conductance catheter and transient inferior vena caval occlusion: their clinical usefulness]. J Cardiol. 1991;21(2):473-80. Japanese. PubMed PMID: 1668750.