Opc 15161

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584920

CAS#: 121071-92-9

Description: Opc 15161 is a degradation product of OPC-15160 and superoxide inhibitor.

Chemical Structure

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Opc 15161
CAS# 121071-92-9
Instruction

Theoretical Analysis

MedKoo Cat#: 584920
Name: Opc 15161
CAS#: 121071-92-9
Chemical Formula: C18H21N3O3
Exact Mass: 327.16
Molecular Weight: 327.384
Elemental Analysis: C, 66.04; H, 6.47; N, 12.84; O, 14.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Opc 15161; Opc-15161; Opc15161

IUPAC/Chemical Name: 2(1H)-Pyrazinone, 6-(1H-indol-3-ylmethyl)-5-methoxy-3-(2-methylpropyl)-, 4-oxide

InChi Key: AFTLYEDBVFGRNK-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H21N3O3/c1-11(2)8-16-17(22)20-15(18(24-3)21(16)23)9-12-10-19-14-7-5-4-6-13(12)14/h4-7,10-11,19H,8-9H2,1-3H3,(H,20,22)

SMILES Code: O=C1C(CC(C)C)=[N+]([O-])C(OC)=C(CC2=CNC3=C2C=CC=C3)N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 327.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Saika S, Yamanaka O, Kawashima Y, Ohkawa K, Ohnishi Y, Ooshima A, Kimura M, Nakano Y, Kao WW. OPC-15161 suppresses the proliferation of Tenon's capsule fibroblasts and the production of type I collagen and fibronectin stimulated by TGF-beta1 in vitro. Curr Eye Res. 1998 Sep;17(9):933-40. PubMed PMID: 9746441.

2: Sanaka T, Nakano Y, Nishimura H, Shinobe M, Higuchi C, Omata M, Nihei H, Sugino N. Therapeutic effect of a newly developed antioxidative agent (OPC-15161) on experimental immune complex nephritis. Nephron. 1997;76(3):315-22. PubMed PMID: 9226233.

3: Sugawara H, Ueno T, Torimura T, Inuzuka S, Tanikawa K. Inhibitory effect of OPC-15161, a component of fungus Thielavia minor, on proliferation and extracellular matrix production of rat cultured hepatic stellate cells. J Cell Physiol. 1998 Mar;174(3):398-406. PubMed PMID: 9462702.

4: Ozawa T, Nakano Y. The radical scavenging abilities of a new anti-nephritic drug, OPC-15161. Biochem Mol Biol Int. 1996 Feb;38(2):231-8. PubMed PMID: 8850518.

5: Nakano Y, Kawaguchi T, Sumitomo J, Takizawa T, Uetsuki S, Sugawara M, Kido M. Novel inhibitors of superoxide anion generation, OPC-15160 and OPC-15161. Taxonomy, fermentation, isolation, physico-chemical properties, biological characteristics and structure determination. J Antibiot (Tokyo). 1991 Jan;44(1):52-8. PubMed PMID: 1848216.

6: Hamada N, Nagase M. In vivo effect of OPC15161, a superoxide scavenger, on anti-Thy1 nephritis. Eur J Pharmacol. 1996 Dec 12;317(1):123-8. PubMed PMID: 8982728.