Hydrocinchonine
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MedKoo CAT#: 322179

CAS#: 485-65-4

Description: Hydrocinchonine is an Alkaloid from Olea europaea. Hydrocinchonine is found in fruits.

Chemical Structure

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Hydrocinchonine
CAS# 485-65-4
Instruction

Theoretical Analysis

MedKoo Cat#: 322179
Name: Hydrocinchonine
CAS#: 485-65-4
Chemical Formula: C19H24N2O
Exact Mass: 296.19
Molecular Weight: 296.414
Elemental Analysis: C, 76.99; H, 8.16; N, 9.45; O, 5.40

Price and Availability

Size Price Availability Quantity
1g USD 350 2 Weeks
5g USD 950 2 Weeks
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Synonym: Hydrocinchonine; Dihydrocinchonine;

IUPAC/Chemical Name: (1S)-((2R,4S,5R)-5-ethylquinuclidin-2-yl)(quinolin-4-yl)methanol

InChi Key: WFJNHVWTKZUUTR-QAMTZSDWSA-N

InChi Code: InChI=1S/C19H24N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h3-7,9,13-14,18-19,22H,2,8,10-12H2,1H3/t13-,14-,18+,19-/m0/s1

SMILES Code: O[C@H]([C@@H]1N2C[C@H](CC)[C@](CC2)([H])C1)C3=CC=NC4=CC=CC=C34

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 296.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cayuelas A, Larrañaga O, Selva V, Nájera C, Akiyama T, Sansano JM, de Cózar A,
Miranda JI, Cossío FP. Cooperative Catalysis with Coupled Chiral Induction in
1,3-Dipolar Cycloadditions of Azomethine Ylides. Chemistry. 2018 Jun
7;24(32):8092-8097. doi: 10.1002/chem.201801433. Epub 2018 May 15. PubMed PMID:
29600546.


2: Lee SY, Rhee YH, Jeong SJ, Lee HJ, Lee HJ, Jung MH, Kim SH, Lee EO, Ahn KS,
Ahn KS, Kim SH. Hydrocinchonine, cinchonine, and quinidine potentiate
paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal
in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26(4):424-31. doi:
10.1002/tox.20568. Epub 2010 Mar 1. PubMed PMID: 20196146.


3: KING H. Conversion of hydroquinidine into hydrocinchonine and of cupreine into
cinchonidine. J Chem Soc. 1946 Jun;(6):523. PubMed PMID: 20280697.