Tetrazanbigen
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565138

CAS#: NONE

Description: Tetrazanbigen is an inducer of S phase arrest and apoptosis in hepatocellular carcinoma QGY-7701.

Chemical Structure

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Tetrazanbigen
CAS# NONE
Instruction

Theoretical Analysis

MedKoo Cat#: 565138
Name: Tetrazanbigen
CAS#: NONE
Chemical Formula: C18H16N4
Exact Mass: 288.14
Molecular Weight: 288.350
Elemental Analysis: C, 74.98; H, 5.59; N, 19.43

Price and Availability

Size Price Availability Quantity
5mg USD 265
25mg USD 630
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Synonym: TNBG; Tetrazanbigen

IUPAC/Chemical Name: 5,6,13,14-Tetrahydro-4bH-6,7,12,12b-tetraaza-benzo[b]chrysene

InChi Key: KQQCOPLSURIQAA-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H16N4/c1-2-6-13-12(5-1)9-10-22-16(13)11-19-17-18(22)21-15-8-4-3-7-14(15)20-17/h1-8,16H,9-11H2,(H,19,20)

SMILES Code: C1(N=C2NCC34)=CC=CC=C1N=C2N4CCC5=C3C=CC=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 288.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zheng X, Li W, Lan Z, Yang X, Li L, Yuan Y, Xia Z, Chen X, Zhang X, Yu Y. Antitumour effects of tetrazanbigen against human hepatocellular carcinoma QGY-7701 through inducing lipid accumulation in vitro and in vivo. J Pharm Pharmacol. 2015 Nov;67(11):1593-602. doi: 10.1111/jphp.12467. Epub 2015 Aug 5. PubMed PMID: 26245909.

2: Yuan YH, Yang XL, Li W, Zheng XH, Gu R, Yu Y. [Subcellular proteomic analysis of Tetrazanbigen on human hepatocellular carcinoma cell line QGY-7701]. Zhonghua Gan Zang Bing Za Zhi. 2011 Dec;19(12):908-11. doi: 10.3760/cma.j.issn.1007-3418.2011.12.007. Chinese. PubMed PMID: 22525503.

3: Yuan Y, Li W, Li L, Yang X, Gu R, Liu H, Huang K, Yu Y. Effects of tetrazanbigen on the protein expression in human hepatocellular carcinoma cell line QGY-7701. J Huazhong Univ Sci Technolog Med Sci. 2009 Jun;29(3):304-8. doi: 10.1007/s11596-009-0308-9. Epub 2009 Jun 10. PubMed PMID: 19513611.

4: Yuan YH, Li W, Yang XL, Li LJ, Gu R, Tang WX, Yu Y. [Changes of protein expressions in human hepatocellular carcinoma cell line QGY-7701 induced by tetrazanbigen]. Zhonghua Gan Zang Bing Za Zhi. 2008 Jun;16(6):463-4. Chinese. PubMed PMID: 18579001.