NS 1608

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584831

CAS#: 160383-80-2

Description: NS 1608 is a BK(Ca) channel opener.

Chemical Structure

img
NS 1608
CAS# 160383-80-2
Instruction

Theoretical Analysis

MedKoo Cat#: 584831
Name: NS 1608
CAS#: 160383-80-2
Chemical Formula: C14H10ClF3N2O2
Exact Mass: 330.04
Molecular Weight: 330.691
Elemental Analysis: C, 50.85; H, 3.05; Cl, 10.72; F, 17.24; N, 8.47; O, 9.68

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: NS 1608; NS1608; NS-1608

IUPAC/Chemical Name: N-(3-(Trifluoromethyl)phenyl)-N'-(2-hydroxy-5-chlorophenyl)urea

InChi Key: KRHJDJMOIKRPNN-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H10ClF3N2O2/c15-9-4-5-12(21)11(7-9)20-13(22)19-10-3-1-2-8(6-10)14(16,17)18/h1-7,21H,(H2,19,20,22)

SMILES Code: O=C(NC1=CC(Cl)=CC=C1O)NC2=CC=CC(C(F)(F)F)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 330.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Strøbaek D, Christophersen P, Holm NR, Moldt P, Ahring PK, Johansen TE, Olesen SP. Modulation of the Ca(2+)-dependent K+ channel, hslo, by the substituted diphenylurea NS 1608, paxilline and internal Ca2+. Neuropharmacology. 1996;35(7):903-14. PubMed PMID: 8938721.

2: Mora TC, Suarez-Kurtz G. Effects of NS1608, a BK(Ca) channel agonist, on the contractility of guinea-pig urinary bladder in vitro. Br J Pharmacol. 2005 Mar;144(5):636-41. PubMed PMID: 15678097; PubMed Central PMCID: PMC1576041.

3: Hu S, Kim HS, Fink CA. Differential effects of the BKCa channel openers NS004 and NS1608 in porcine coronary arterial cells. Eur J Pharmacol. 1995 Dec 27;294(1):357-60. PubMed PMID: 8788454.

4: Ahring PK, Strøbaek D, Christophersen P, Olesen SP, Johansen TE. Stable expression of the human large-conductance Ca2+-activated K+ channel alpha- and beta-subunits in HEK293 cells. FEBS Lett. 1997 Sep 22;415(1):67-70. PubMed PMID: 9326371.

5: Hu S, Kim HS. On the mechanism of the differential effects of NS004 and NS1608 in smooth muscle cells from guinea pig bladder. Eur J Pharmacol. 1996 Dec 30;318(2-3):461-8. PubMed PMID: 9016939.

6: Siemer C, Bushfield M, Newgreen D, Grissmer S. Effects of NS1608 on MaxiK channels in smooth muscle cells from urinary bladder. J Membr Biol. 2000 Jan 1;173(1):57-66. PubMed PMID: 10612692. a