NK 2

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584810

CAS#: 26351-71-3

Description: NK 2 is a membrane-acting antimicrobial peptide.

Chemical Structure

img
NK 2
CAS# 26351-71-3
Instruction

Theoretical Analysis

MedKoo Cat#: 584810
Name: NK 2
CAS#: 26351-71-3
Chemical Formula: C15H11Cl2NO6
Exact Mass: 371.00
Molecular Weight: 372.154
Elemental Analysis: C, 48.41; H, 2.98; Cl, 19.05; N, 3.76; O, 25.79

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: NK 2; NK-2; NK2

IUPAC/Chemical Name: (2,4-Dichlorophenoxy)acetic acid, (4-hydroxy-3-nitrophenyl)methyl ester

InChi Key: YHLOHJDPOCXQQD-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H11Cl2NO6/c16-10-2-4-14(11(17)6-10)23-8-15(20)24-7-9-1-3-13(19)12(5-9)18(21)22/h1-6,19H,7-8H2

SMILES Code: O=C(OCC1=CC=C(O)C([N+]([O-])=O)=C1)COC2=CC=C(Cl)C=C2Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 372.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Andrä J, Koch MH, Bartels R, Brandenburg K. Biophysical characterization of endotoxin inactivation by NK-2, an antimicrobial peptide derived from mammalian NK-lysin. Antimicrob Agents Chemother. 2004 May;48(5):1593-9. PubMed PMID: 15105110; PubMed Central PMCID: PMC400566.

2: Hsu CC, Lin RL, Lin YS, Lee LY. Bronchoconstriction induced by increasing airway temperature in ovalbumin-sensitized rats: role of tachykinins. J Appl Physiol (1985). 2013 Sep 1;115(5):688-96. doi: 10.1152/japplphysiol.00491.2013. Epub 2013 Jul 11. PubMed PMID: 23845978; PubMed Central PMCID: PMC3763070.

3: Dragan AI, Li Z, Makeyeva EN, Milgotina EI, Liu Y, Crane-Robinson C, Privalov PL. Forces driving the binding of homeodomains to DNA. Biochemistry. 2006 Jan 10;45(1):141-51. PubMed PMID: 16388589.

4: Jena P, Mishra B, Leippe M, Hasilik A, Griffiths G, Sonawane A. Membrane-active antimicrobial peptides and human placental lysosomal extracts are highly active against mycobacteria. Peptides. 2011 May;32(5):881-7. doi: 10.1016/j.peptides.2011.03.002. Epub 2011 Mar 17. PubMed PMID: 21396418.