PE 154
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531384

CAS#: 1192750-33-6

Description: PE 154 are known to associate with β-amyloid plaques, and histological co-localization of AChE and Ab peptides is well established in Alzheimer’s disease. PE-154 is a fluorescent inhibitor of both AChE and BChE with IC50 values of 280 pM and 16 nM. PE-154 stains Aβ plaques in both rodent and human tissue samples, and does not cross react with phospho-tau.

Chemical Structure

img
PE 154
CAS# 1192750-33-6
Instruction

Theoretical Analysis

MedKoo Cat#: 531384
Name: PE 154
CAS#: 1192750-33-6
Chemical Formula: C36H35N5O6
Exact Mass: 633.26
Molecular Weight: 633.705
Elemental Analysis: C, 68.23; H, 5.57; N, 11.05; O, 15.15

Price and Availability

Size Price Availability Quantity
50mg USD 750 2 Weeks
100mg USD 1350 2 Weeks
200mg USD 2050 2 Weeks
500mg USD 3250 2 Weeks
1g USD 4850 2 Weeks
2g USD 6450 2 Weeks
Bulk inquiry

Synonym: PE 154; PE-154; PE154;

IUPAC/Chemical Name: 2-(1,2,3,4-Tetrahydro-9-acridinyl)hydrazide-4-[[[7-(diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid

InChi Key: UYUDDVCVNXNAOT-USHMODERSA-N

InChi Code: InChI=1S/C36H35N5O6/c1-3-41(4-2)23-12-13-25-31(18-23)47-36(46)28(34(25)44)19-38-22-11-9-20(16-32(42)43)26(17-22)33-24-7-5-6-8-29(24)39-30-14-10-21(15-27(30)33)35(45)40-37/h5-9,11-13,17-19,21,38H,3-4,10,14-16,37H2,1-2H3,(H,40,45)(H,42,43)/b28-19-

SMILES Code: O=C(O)CC1=CC=C(N/C=C(C(C2=CC=C(N(CC)CC)C=C2O3)=O)\C3=O)C=C1C4=C(CC(C(NN)=O)CC5)C5=NC6=CC=CC=C64

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 633.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Brambilla D, Le Droumaguet B, Nicolas J, Hashemi SH, Wu LP, Moghimi SM, Couvreur P, Andrieux K. Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues. Nanomedicine. 2011 Oct;7(5):521-40. doi: 10.1016/j.nano.2011.03.008. Epub 2011 Apr 6. Review. PubMed PMID: 21477665.

2: Härtig W, Kacza J, Paulke BR, Grosche J, Bauer U, Hoffmann A, Elsinghorst PW, Gütschow M. In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. Eur J Neurosci. 2010 Jan;31(1):99-109. doi: 10.1111/j.1460-9568.2009.07038.x. Epub 2009 Dec 21. PubMed PMID: 20092557.