Isogambogic acid | CAS# 149655-52-7 | Antitumor Agent

Isogambogic Acid
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564533

CAS#: 149655-52-7

Description: Isogambogic acid is a natural antitumor agent which is active against KB and drug-resistant KB-V1 cell lines.

Chemical Structure

Isogambogic Acid

CAS# 149655-52-7

Instruction

Theoretical Analysis

MedKoo Cat#: 564533
Name: Isogambogic Acid
CAS#: 149655-52-7
Chemical Formula: C38H44O8
Exact Mass: 628.30
Molecular Weight: 628.760
Elemental Analysis: C, 72.59; H, 7.05; O, 20.36

Price and Availability

Size	Price	Availability
5mg	USD 750	2 Weeks
10mg	USD 1250	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Isogambogic acid

IUPAC/Chemical Name: 2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2E)-

InChi Key: GEZHEQNLKAOMCA-GXSDCXQCSA-N

InChi Code: InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13+/t23-,27+,36-,37+,38-/m1/s1

SMILES Code: C/C(C)=C\CC[C@]1(C)C=CC2=C(C(C/C=C(C)\C)=C3C(C(C4=C[C@]([H])(C5)C([C@@]6(C/C=C(C(O)=O)\C)[C@@]4([C@]5([H])C(C)(C)O6)O3)=O)=O)=C2O)O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 628.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Han QB, Zhou Y, Feng C, Xu G, Huang SX, Li SL, Qiao CF, Song JZ, Chang DC, Luo KQ, Xu HX. Bioassay guided discovery of apoptosis inducers from gamboge by high-speed counter-current chromatography and high-pressure liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 1;877(4):401-7. doi: 10.1016/j.jchromb.2008.12.046. Epub 2008 Dec 25. PubMed PMID: 19124287.

2: Li SL, Song JZ, Han QB, Qiao CF, Xu HX. Improved high-performance liquid chromatographic method for simultaneous determination of 12 cytotoxic caged xanthones in gamboges, a potential anticancer resin from Garcinia hanburyi. Biomed Chromatogr. 2008 Jun;22(6):637-44. doi: 10.1002/bmc.981. PubMed PMID: 18254140.

3: Abbas S, Bhoumik A, Dahl R, Vasile S, Krajewski S, Cosford ND, Ronai ZA. Preclinical studies of celastrol and acetyl isogambogic acid in melanoma. Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6769-78. PubMed PMID: 18006779; PubMed Central PMCID: PMC2874065.

4: Song JZ, Yip YK, Han QB, Qiao CF, Xu HX. Rapid determination of polyprenylated xanthones in gamboge resin of Garcinia hanburyi by HPLC. J Sep Sci. 2007 Feb;30(3):304-9. PubMed PMID: 17396587.

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