TC 2559 (fumarate)
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MedKoo CAT#: 584682

CAS#: 212332-35-9

Description: TC 2559 (fumarate) is a CNS-selective partial agonist for α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) with an EC50 value of 0.18 µM for calcium signaling in HEK293 cells expressing human recombinant nAChRs.

Chemical Structure

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TC 2559 (fumarate)
CAS# 212332-35-9
Instruction

Theoretical Analysis

MedKoo Cat#: 584682
Name: TC 2559 (fumarate)
CAS#: 212332-35-9
Chemical Formula: C20H26N2O9
Exact Mass: 438.16
Molecular Weight: 438.433
Elemental Analysis: C, 54.79; H, 5.98; N, 6.39; O, 32.84

Price and Availability

Size Price Availability Quantity
1mg USD 210
5mg USD 405
10mg USD 640
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Synonym: TC 2559 (fumarate)

IUPAC/Chemical Name: 4-(5-ethoxy-3-pyridinyl)-N-methyl-3-buten-1-amine, difumaric acid

InChi Key: GEWVPSJQGJBDLM-MYBAKCFCSA-N

InChi Code: InChI=1S/C12H18N2O.2C4H4O4/c1-3-15-12-8-11(9-14-10-12)6-4-5-7-13-2;2*5-3(6)1-2-4(7)8/h4,6,8-10,13H,3,5,7H2,1-2H3;2*1-2H,(H,5,6)(H,7,8)/b6-4+;2*2-1+

SMILES Code: CNCC/C=C/C1=CC(OCC)=CN=C1.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O

Appearance: Solid powder

Purity: ≥95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 438.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Bencherif, M., Bane, A.J., Miller, C.H., et al. TC-2559: A novel orally active ligand selective at neuronal acetylcholine receptors Eur. J. Pharmacol. 409(1), 45-55 (2000).

2. Chen, Y., Sharples, T.J.W., Phillips, K.G., et al. The nicotinic α4β2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices Neuropharmacology 45(3), 334-344 (2003).

3. Cheng, L.-Z., Han, L., Fan, J., et al. Enhanced inhibitory synaptic transmission in the spinal dorsal horn mediates antinociceptive effects of TC-2559 Mol. Pain 7:56, (2011).