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MedKoo CAT#: 555368

CAS#: 281224-40-6

Description: M-31850 is a β-Hexosaminidase Inhibitor. M-31850 showed activity against the insect β-N-acetyl-D-hexosaminidase OfHex2. M-31850 acts as a substrate-competitive and selective inhibitor against human β-N-acetyl hexosaminidase (IC50 = 6.0 & 3.1 µM for hHex A & hHex B, respectively), while exhibiting much reduced potency against Jack Bean or bacterial Hex (IC50 = 280 & >500 µM for JBHex & SpHex, respectively) and little or no activity against SmHex or hOGN.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-08-11. Prices are subject to change without notice.

M-31850 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 555368
Name: M-31850
CAS#: 281224-40-6
Chemical Formula: C28H21N3O4
Exact Mass: 463.1532
Molecular Weight: 463.493
Elemental Analysis: C, 72.56; H, 4.57; N, 9.07; O, 13.81

Synonym: M-31850; M 31850; M31850;

IUPAC/Chemical Name: 2,2'-(azanediylbis(ethane-2,1-diyl))bis(1H-benzo[de]isoquinoline-1,3(2H)-dione)


InChi Code: InChI=1S/C28H21N3O4/c32-25-19-9-1-5-17-6-2-10-20(23(17)19)26(33)30(25)15-13-29-14-16-31-27(34)21-11-3-7-18-8-4-12-22(24(18)21)28(31)35/h1-12,29H,13-16H2


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

The GH20 β-N-acetyl-d-hexosaminidase OfHex2 from the insect Ostrinia furnacalis (Guenée) is a target potential for eco-friendly pesticide development. Although carbohydrate-based inhibitors against β-N-acetyl-D-hexosaminidases are widely studied, highly efficient, non-carbohydrate inhibitors are more attractive due to low cost and readily synthetic manner.


1: Liu T, Guo P, Zhou Y, Wang J, Chen L, Yang H, Qian X, Yang Q. A crystal
structure-guided rational design switching non-carbohydrate inhibitors'
specificity between two β-GlcNAcase homologs. Sci Rep. 2014 Aug 26;4:6188. doi:
10.1038/srep06188. PubMed PMID: 25155420; PubMed Central PMCID: PMC4143770.

2: Chen Q, Guo P, Xu L, Liu T, Qian X, Yang Q. Exploring unsymmetrical dyads as
efficient inhibitors against the insect β-N-acetyl-D-hexosaminidase OfHex2.
Biochimie. 2014 Feb;97:152-62. doi: 10.1016/j.biochi.2013.10.008. Epub 2013 Oct
17. PubMed PMID: 24140956.