Conjugated linoleic acid

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528086

CAS#: 121250-47-3

Description: Conjugated linoleic acid is a naturally occurring fatty acid that is produced by a bio-hydrogenation process in the rumen, and thus is present in dairy products and ruminant meat. In this case the predominant isomer formed is 9cis,11trans. However, CLA includes 28 positional and geometrical isomers, of which only 9cis,11trans and 10trans,12cis have thus far been proven to possess biological activities.

Chemical Structure

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Conjugated linoleic acid
CAS# 121250-47-3
Instruction

Theoretical Analysis

MedKoo Cat#: 528086
Name: Conjugated linoleic acid
CAS#: 121250-47-3
Chemical Formula: C18H32O2
Exact Mass: 280.24
Molecular Weight: 280.452
Elemental Analysis: C, 77.09; H, 11.50; O, 11.41

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Conjugated linoleic acid

IUPAC/Chemical Name: 9,11(or 10,12)-Octadecadienoic acid

InChi Key: JBYXPOFIGCOSSB-XBLVEGMJSA-N

InChi Code: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-10H,2-6,11-17H2,1H3,(H,19,20)/b8-7+,10-9+

SMILES Code: CCCCCC/C=C/C=C/CCCCCCCC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 280.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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5: Yang Y, Sadri H, Prehn C, Adamski J, Rehage J, Dänicke S, Saremi B, Sauerwein H. Acylcarnitine profiles in serum and muscle of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation. J Dairy Sci. 2018 Oct 18. pii: S0022-0302(18)30971-8. doi: 10.3168/jds.2018-14685. [Epub ahead of print] PubMed PMID: 30343917.

6: Santiago BM, da Silva FF, Silva RR, Costa EGL, Porto Junior AF, Costa EN, de Souza DD. Effect of different roughages sources on performance, milk composition, fatty acid profile, and milk cholesterol content of feedlot feed crossbred cows (Holstein × Zebu). Trop Anim Health Prod. 2018 Oct 19. doi: 10.1007/s11250-018-1736-y. [Epub ahead of print] PubMed PMID: 30341663.

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8: Pereira de Melo IL, de Oliveira E Silva AM, Yoshime LT, Gasparotto Sattler JA, Teixeira de Carvalho EB, Mancini-Filho J. Punicic acid was metabolised and incorporated in the form of conjugated linoleic acid in different rat tissues. Int J Food Sci Nutr. 2018 Oct 17:1-11. doi: 10.1080/09637486.2018.1519528. [Epub ahead of print] PubMed PMID: 30326753.

9: Gonçalves DC, Lira FS, Yamashita AS, Carnevali Junior LC, Eder R, Laviano A, Seelaender MCL. Liver lipid metabolism disruption in cancer cachexia is aggravated by cla supplementation -induced inflammation. Clin Nutr. 2018 Sep 25. pii: S0261-5614(18)32461-0. doi: 10.1016/j.clnu.2018.09.023. [Epub ahead of print] PubMed PMID: 30322784.

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11: Kanter JE, Goodspeed L, Wang S, Kramer F, Wietecha T, Gomes-Kjerulf D, Subramanian S, O'Brien KD, den Hartigh LJ. 10,12 Conjugated Linoleic Acid-Driven Weight Loss Is Protective against Atherosclerosis in Mice and Is Associated with Alternative Macrophage Enrichment in Perivascular Adipose Tissue. Nutrients. 2018 Oct 3;10(10). pii: E1416. doi: 10.3390/nu10101416. PubMed PMID: 30282904; PubMed Central PMCID: PMC6213611.

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19: Queiroz MP, Lima MDS, de Melo MFFT, Bertozzo CCMS, de Araújo DF, Guerra GCB, Queiroga RCRDE, Soares JKB. Maternal suppplementation with conjugated linoleic acid reduce anxiety and lipid peroxidation in the offspring brain. J Affect Disord. 2019 Jan 15;243:75-82. doi: 10.1016/j.jad.2018.09.020. Epub 2018 Sep 11. PubMed PMID: 30236761.

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