Nexinhib20
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584635

CAS#: 331949-35-0

Description: Nexinhib20 is a Rab27 inhibitor that inhibits neutrophil exocytosis and is active in vivo.

Chemical Structure

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Nexinhib20
CAS# 331949-35-0
Instruction

Theoretical Analysis

MedKoo Cat#: 584635
Name: Nexinhib20
CAS#: 331949-35-0
Chemical Formula: C15H16N4O3
Exact Mass: 300.12
Molecular Weight: 300.318
Elemental Analysis: C, 59.99; H, 5.37; N, 18.66; O, 15.98

Price and Availability

Size Price Availability Quantity
5mg USD 250
25mg USD 560
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Synonym: Nexinhib20

IUPAC/Chemical Name: 4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one

InChi Key: VKSOIYNNOFGGES-JYRVWZFOSA-N

InChi Code: InChI=1S/C15H16N4O3/c1-15(2,3)14(20)13(18-10-16-9-17-18)8-11-5-4-6-12(7-11)19(21)22/h4-10H,1-3H3/b13-8-

SMILES Code: CC(C)(C)C(/C(N1N=CN=C1)=C/C2=CC=CC([N+]([O-])=O)=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 300.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Johnson et al (2016) Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small GTPase Rab27a. J.Biol.Chem. 291 25965 PMID: 27702998