JRC-II-191

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564016

CAS#: NONE

Description: JRC-II-191 is an inhibitor of CD4-gp120 binding, blocking the binding of the HIV-1 envelope glycoprotein gp120 to the CD4 receptor.

Chemical Structure

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JRC-II-191
CAS# NONE
Instruction

Theoretical Analysis

MedKoo Cat#: 564016
Name: JRC-II-191
CAS#: NONE
Chemical Formula: C17H23ClFN3O2
Exact Mass: 355.15
Molecular Weight: 355.840
Elemental Analysis: C, 57.38; H, 6.52; Cl, 9.96; F, 5.34; N, 11.81; O, 8.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JRC-II-191; JRCII191; JRC II 191; JRCII-191; JRC-II191; JRC II-191; JRC-II 191

IUPAC/Chemical Name: N-(4-Chloro-3-fluoro-phenyl)-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide

InChi Key: WNIRIUAQGASKHI-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H23ClFN3O2/c1-16(2)8-11(9-17(3,4)22-16)21-15(24)14(23)20-10-5-6-12(18)13(19)7-10/h5-7,11,22H,8-9H2,1-4H3,(H,20,23)(H,21,24)

SMILES Code: O=C(NC1=CC=C(Cl)C(F)=C1)C(NC2CC(C)(C)NC(C)(C)C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 355.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lalonde JM, Elban MA, Courter JR, Sugawara A, Soeta T, Madani N, Princiotto AM, Kwon YD, Kwong PD, Schön A, Freire E, Sodroski J, Smith AB 3rd. Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening. Bioorg Med Chem. 2011 Jan 1;19(1):91-101. doi: 10.1016/j.bmc.2010.11.049. Epub 2010 Nov 26. PubMed PMID: 21169023; PubMed Central PMCID: PMC3049263.

2: Haim H, Si Z, Madani N, Wang L, Courter JR, Princiotto A, Kassa A, DeGrace M, McGee-Estrada K, Mefford M, Gabuzda D, Smith AB 3rd, Sodroski J. Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state. PLoS Pathog. 2009 Apr;5(4):e1000360. doi: 10.1371/journal.ppat.1000360. Epub 2009 Apr 3. PubMed PMID: 19343205; PubMed Central PMCID: PMC2655723.