DDOH | CAS#2642-82-2 | metabolite of DDT

DDOH
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581351

CAS#: 2642-82-2

Description: DDOH is a metabolite of DDT and forms conjugates with palmitic acid in DDT-treated female rats.

Chemical Structure

DDOH

CAS# 2642-82-2

Instruction

Theoretical Analysis

MedKoo Cat#: 581351
Name: DDOH
CAS#: 2642-82-2
Chemical Formula: C14H12Cl2O
Exact Mass: 266.03
Molecular Weight: 267.149
Elemental Analysis: C, 62.94; H, 4.53; Cl, 26.54; O, 5.99

Price and Availability

Size	Price	Availability	Quantity
1g	USD 450	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: DDOH; DDOM; p,p'-Ddoh;

IUPAC/Chemical Name: 2,2-Bis(4-chlorophenyl)-1-hydroxyethane

InChi Key: ZVIDYKRNLNAXFT-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H12Cl2O/c15-12-5-1-10(2-6-12)14(9-17)11-3-7-13(16)8-4-11/h1-8,14,17H,9H2

SMILES Code: OCC(C1=CC=C(Cl)C=C1)C2=CC=C(Cl)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 267.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sova O, Reshetnyak V, Galstian T. Modulation transfer function of liquid crystal microlenses and microprisms using double dielectric layer. Appl Opt. 2018 Jan 1;57(1):18-24. doi: 10.1364/AO.57.000018. PubMed PMID: 29328107.

2: Pan X, Lin D, Zheng Y, Zhang Q, Yin Y, Cai L, Fang H, Yu Y. Biodegradation of DDT by Stenotrophomonas sp. DDT-1: Characterization and genome functional analysis. Sci Rep. 2016 Feb 18;6:21332. doi: 10.1038/srep21332. PubMed PMID: 26888254; PubMed Central PMCID: PMC4758049.

3: Han Y, Shi N, Wang H, Pan X, Fang H, Yu Y. Nanoscale zerovalent iron-mediated degradation of DDT in soil. Environ Sci Pollut Res Int. 2016 Apr;23(7):6253-63. doi: 10.1007/s11356-015-5850-3. Epub 2015 Nov 27. PubMed PMID: 26611630.

4: Lu D, Wang D, Ni R, Lin Y, Feng C, Xu Q, Jia X, Wang G, Zhou Z. Organochlorine pesticides and their metabolites in human breast milk from Shanghai, China. Environ Sci Pollut Res Int. 2015 Jun;22(12):9293-306. doi: 10.1007/s11356-015-4072-z. Epub 2015 Jan 18. PubMed PMID: 25595932.

5: Scollon EJ, Carr JA, Rintoul DA, McMurry ST, Cobb GP. Metabolism and distribution of p,p'-DDT during flight of the white-crowned sparrow, Zonotrichia leucophrys. Environ Toxicol Chem. 2012 Feb;31(2):336-46. doi: 10.1002/etc.730. Epub 2011 Dec 14. PubMed PMID: 22045600.

6: Eggen T, Majcherczyk A. Effects of zero-valent iron (Fe0) and temperature on the transformation of DDT and its metabolites in lake sediment. Chemosphere. 2006 Feb;62(7):1116-25. Epub 2005 Aug 8. PubMed PMID: 16087216.

7: Mitra J, Mukherjee PK, Kale SP, Murthy NB. Bioremediation of DDT in soil by genetically improved strains of soil fungus Fusarium solani. Biodegradation. 2001;12(4):235-45. PubMed PMID: 11826906.

8: Klotz DM, Ladlie BL, Vonier PM, McLachlan JA, Arnold SF. o,p'-DDT and its metabolites inhibit progesterone-dependent responses in yeast and human cells. Mol Cell Endocrinol. 1997 Apr 25;129(1):63-71. PubMed PMID: 9175630.

9: Eriksson P. DDT and pyrethroids--ecotoxicological considerations. Comp Biochem Physiol C. 1991;100(1-2):269-70. Review. PubMed PMID: 1677862.

10: Eriksson P, Archer T, Fredriksson A. Altered behaviour in adult mice exposed to a single low dose of DDT and its fatty acid conjugate as neonates. Brain Res. 1990 Apr 23;514(1):141-2. PubMed PMID: 2357521.

11: Eriksson P, Nilsson-Håkansson L, Nordberg A, Aspberg A, Fredriksson A. Neonatal exposure to DDT and its fatty acid conjugate: effects on cholinergic and behavioural variables in the adult mouse. Neurotoxicology. 1990 Summer;11(2):345-54. PubMed PMID: 2234550.

12: Fawcett SC, King LJ, Bunyan PJ, Stanley PI. The metabolism of 14C-DDT, 14C-DDD, 14C-DDE and 14C-DDMU in rats and Japanese quail. Xenobiotica. 1987 May;17(5):525-38. PubMed PMID: 3604258.

13: Kujawa M, Macholz R, Knoll R, Plass R. [The enzymatic degradation of DDT. 6. The fate of the DDT metabolites dichlorodiphenyldichloroethylene and dichlorodiphenylmonochloroethylene in the rat]. Nahrung. 1987;31(3):253-7. German. PubMed PMID: 3614335.

14: Eriksson P, Nordberg A. The effects of DDT, DDOH-palmitic acid, and a chlorinated paraffin on muscarinic receptors and the sodium-dependent choline uptake in the central nervous system of immature mice. Toxicol Appl Pharmacol. 1986 Sep 15;85(2):121-7. PubMed PMID: 3764899.

15: Treinen KA, Kulkarni AP. Human placental Ca2+-ATPase: in vitro inhibition by DDT homologs. Toxicol Lett. 1986 Mar;30(3):223-9. PubMed PMID: 2939596.

16: Gold B, Brunk G. A mechanistic study of the metabolism of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) to 2,2-bis(p-chlorophenyl)acetic acid (DDA). Biochem Pharmacol. 1984 Apr 1;33(7):979-82. PubMed PMID: 6712728.

17: Gold B, Brunk G. Metabolism of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane in the mouse. Chem Biol Interact. 1982 Sep;41(3):327-39. PubMed PMID: 7105253.

18: Leighty EG, Fentiman AF Jr, Thompson RM. Conjugation of fatty acids to DDT in the rat: possible mechanism for retention. Toxicology. 1980;15(2):77-82. PubMed PMID: 7376193.

19: Planche G, Croisy A, Malaveille C, Tomatis L, Bartsch H. Metabolic and mutagenicity studies on DDT and 15 derivatives. Detection of 1,1-bis(p-chlorophenyl)-2,2-dichloroethane and 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethyl acetate (kelthane acetate) as mutagens in Salmonella typhimurium and of 1,1-bis(p-chlorophenyl) ethylene oxide, a likely metabolite, as an alkylating agent. Chem Biol Interact. 1979 May;25(2-3):157-75. PubMed PMID: 380827.

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