Photoregulin3
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563830

CAS#: 785708-33-0

Description: Photoregulin3 is a inhibitor of rod photoreceptor gene expression, potentially though Nr2e3 modulation.

Chemical Structure

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Photoregulin3
CAS# 785708-33-0
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 563830
Name: Photoregulin3
CAS#: 785708-33-0
Chemical Formula: C22H23N3O3
Exact Mass: 377.17
Molecular Weight: 377.444
Elemental Analysis: C, 70.01; H, 6.14; N, 11.13; O, 12.72

Price and Availability

Size Price Availability Quantity
5mg USD 295
25mg USD 750
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Synonym: Photoregulin3; Photoregulin 3; Photoregulin-3; PR3; PR 3; PR-3

IUPAC/Chemical Name: 6,7-Dimethoxy-2-((4-phenyl-3,6-dihydropyridin-1(2H)-yl)methyl)quinazolin-4-ol

InChi Key: CKCSOMMBIPJYSG-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H23N3O3/c1-27-19-12-17-18(13-20(19)28-2)23-21(24-22(17)26)14-25-10-8-16(9-11-25)15-6-4-3-5-7-15/h3-8,12-13H,9-11,14H2,1-2H3,(H,23,24,26)

SMILES Code: OC1=C2C=C(OC)C(OC)=CC2=NC(CN3CC=C(C4=CC=CC=C4)CC3)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: T4 is a modulator of alternative polyadenylation (APA) (IC50 values are 2.1 μM and 8.5 μM in U2OS and 293T cells, respectively).
In vitro activity: TBD
In vivo activity: This study reports a structurally unrelated compound, Photoregulin3 (PR3) that also inhibits rod photoreceptor gene expression, potentially though Nr2e3 modulation. To determine the effectiveness of PR3 as a potential therapy for RP, this study treated RhoP23H mice with PR3 and assessed retinal structure and function. PR3-treated RhoP23H mice showed significant structural and functional photoreceptor rescue compared with vehicle-treated littermate control mice. Reference: Elife. 2017 Nov 17;6:e30577. https://pubmed.ncbi.nlm.nih.gov/29148976/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.8 2.00

Preparing Stock Solutions

The following data is based on the product molecular weight 377.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: Nakamura PA, Shimchuk AA, Tang S, Wang Z, DeGolier K, Ding S, Reh TA. Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa. Elife. 2017 Nov 17;6:e30577. doi: 10.7554/eLife.30577. PMID: 29148976; PMCID: PMC5693111.
In vitro protocol: TBD
In vivo protocol: Nakamura PA, Shimchuk AA, Tang S, Wang Z, DeGolier K, Ding S, Reh TA. Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa. Elife. 2017 Nov 17;6:e30577. doi: 10.7554/eLife.30577. PMID: 29148976; PMCID: PMC5693111.

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1: Nakamura PA, Shimchuk AA, Tang S, Wang Z, DeGolier K, Ding S, Reh TA. Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa. Elife. 2017 Nov 17;6. pii: e30577. doi: 10.7554/eLife.30577. PubMed PMID: 29148976; PubMed Central PMCID: PMC5693111.