TC299423

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563765

CAS#: 1975146-56-5

Description: TC299423 is a novel agonist for nicotinic acetylcholine receptors (nAChRs). TC299423 modestly selectively targets α6β2 subtype.

Chemical Structure

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TC299423
CAS# 1975146-56-5
Instruction

Theoretical Analysis

MedKoo Cat#: 563765
Name: TC299423
CAS#: 1975146-56-5
Chemical Formula: C11H15N3
Exact Mass: 189.13
Molecular Weight: 189.260
Elemental Analysis: C, 69.81; H, 7.99; N, 22.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: TC299423; TC 299423; TC-299423

IUPAC/Chemical Name: 5-Pyrimidin-5-yl-1,2,3,4,7,8-hexahydro-azocine

InChi Key: CRKXSTOXONBMMP-XCVCLJGOSA-N

InChi Code: InChI=1S/C11H15N3/c1-3-10(4-2-6-12-5-1)11-7-13-9-14-8-11/h3,7-9,12H,1-2,4-6H2/b10-3+

SMILES Code: C1(/C2=CN=CN=C2)=C\CCNCCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 189.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wall TR, Henderson BJ, Voren G, Wageman CR, Deshpande P, Cohen BN, Grady SR, Marks MJ, Yohannes D, Kenny PJ, Bencherif M, Lester HA. TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors. Front Pharmacol. 2017 Sep 26;8:641. doi: 10.3389/fphar.2017.00641. eCollection 2017. PubMed PMID: 29033834; PubMed Central PMCID: PMC5626944.

2: Post MR, Tender GS, Lester HA, Dougherty DA. Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors. eNeuro. 2017 Mar 30;4(2). pii: ENEURO.0032-17.2017. doi: 10.1523/ENEURO.0032-17.2017. eCollection 2017 Mar-Apr. PubMed PMID: 28589175; PubMed Central PMCID: PMC5458768.

3: Post MR, Lester HA, Dougherty DA. Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors. Biochemistry. 2017 Apr 4;56(13):1836-1840. doi: 10.1021/acs.biochem.7b00213. Epub 2017 Mar 21. PubMed PMID: 28287260; PubMed Central PMCID: PMC6075822.

4: Post MR, Limapichat W, Lester HA, Dougherty DA. Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors. Neuropharmacology. 2015 Oct;97:376-82. doi: 10.1016/j.neuropharm.2015.04.009. Epub 2015 Apr 20. PubMed PMID: 25908401; PubMed Central PMCID: PMC4635625.