Toltrazuril
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563712

CAS#: 69004-03-1

Description: Toltrazuril (Tol) is a broad-spectrum anticoccidiosis drug that is widely used in the prevention and treatment of coccidiosis infection in poultry and mammals.

Chemical Structure

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Toltrazuril
CAS# 69004-03-1
Instruction

Theoretical Analysis

MedKoo Cat#: 563712
Name: Toltrazuril
CAS#: 69004-03-1
Chemical Formula: C18H14F3N3O4S
Exact Mass: 425.07
Molecular Weight: 425.380
Elemental Analysis: C, 50.82; H, 3.32; F, 13.40; N, 9.88; O, 15.04; S, 7.54

Price and Availability

Size Price Availability Quantity
500mg USD 210
1g USD 350
5g USD 670
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Synonym: Toltrazuril; Baycox;

IUPAC/Chemical Name: 1-Methyl-3-[3-methyl-4-[4-(trifluoromethylsulfanyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione

InChi Key: OCINXEZVIIVXFU-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H14F3N3O4S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)28-12-4-6-13(7-5-12)29-18(19,20)21/h3-9H,1-2H3,(H,22,25,26)

SMILES Code: O=C(N(C1=CC=C(OC2=CC=C(SC(F)(F)F)C=C2)C(C)=C1)C(N3)=O)N(C)C3=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 425.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ademola IO, Ojo PO, Odeniran PO. Pleurotus ostreatus extract inhibits Eimeria species development in naturally infected broiler chickens. Trop Anim Health Prod. 2018 Jul 14. doi: 10.1007/s11250-018-1665-9. [Epub ahead of print] PubMed PMID: 30008132.

2: Sokól R, Galecki R. The resistance of Eimeria spp. to toltrazuril in black grouse (Lyrurus tetrix) kept in an aviary. Poult Sci. 2018 Jul 10. doi: 10.3382/ps/pey296. [Epub ahead of print] PubMed PMID: 29992279.

3: Odden A, Enemark HL, Ruiz A, Robertson LJ, Ersdal C, Nes SK, Tømmerberg V, Stuen S. Controlled efficacy trial confirming toltrazuril resistance in a field isolate of ovine Eimeria spp. Parasit Vectors. 2018 Jul 5;11(1):394. doi: 10.1186/s13071-018-2976-4. PubMed PMID: 29976240; PubMed Central PMCID: PMC6034276.

4: Odden A, Denwood MJ, Stuen S, Robertson LJ, Ruiz A, Hamnes IS, Hektoen L, Enemark HL. Field evaluation of anticoccidial efficacy: A novel approach demonstrates reduced efficacy of toltrazuril against ovine Eimeria spp. in Norway. Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):304-311. doi: 10.1016/j.ijpddr.2018.05.002. Epub 2018 May 16. PubMed PMID: 29777962; PubMed Central PMCID: PMC6039322.

5: Pietruk K, Olejnik M, Posyniak A. Coccidiostats in milk: development of a multi-residue method and transfer of salinomycin and lasalocid from contaminated feed. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Jun 6:1-11. doi: 10.1080/19440049.2018.1461256. [Epub ahead of print] PubMed PMID: 29648988.

6: Zhang L, Liu M, Lu C, Ren D, Fan G, Liu C, Liu M, Shu G, Peng G, Yuan Z, Zhong Z, Zhang W, Fu H. The hydroxypropyl-β-cyclodextrin complexation of toltrazuril for enhancing bioavailability. Drug Des Devel Ther. 2018 Mar 19;12:583-589. doi: 10.2147/DDDT.S157611. eCollection 2018. PubMed PMID: 29593381; PubMed Central PMCID: PMC5865576.

7: Joachim A, Shrestha A, Freudenschuss B, Palmieri N, Hinney B, Karembe H, Sperling D. Comparison of an injectable toltrazuril-gleptoferron (Forceris®) and an oral toltrazuril (Baycox®) + injectable iron dextran for the control of experimentally induced piglet cystoisosporosis. Parasit Vectors. 2018 Mar 27;11(1):206. doi: 10.1186/s13071-018-2797-5. PubMed PMID: 29580269; PubMed Central PMCID: PMC5870915.

8: Zhang L, Ren D, Zhou J, Peng G, Shu G, Yuan Z, Shi F, Zhao L, Yin L, Fan G, Liu C, Fu H. Toltrazuril mixed nanomicelle delivery system based on sodium deoxycholate-Brij C20 polyethylene ether-triton x100: Characterization, solubility, and bioavailability study. Colloids Surf B Biointerfaces. 2018 Mar 1;163:125-132. doi: 10.1016/j.colsurfb.2017.12.018. Epub 2017 Dec 16. PubMed PMID: 29289823.

9: El-Ghoneimy A, El-Shahawy I. Evaluation of amprolium and toltrazuril efficacy in controlling natural intestinal rabbit coccidiosis. Iran J Vet Res. 2017 Summer;18(3):164-169. PubMed PMID: 29163644; PubMed Central PMCID: PMC5674438.

10: de Souza Rodrigues F, Cezar AS, de Menezes FR, Sangioni LA, Vogel FSF, de Avila Botton S. Efficacy and economic analysis of two treatment regimens using toltrazuril in lambs naturally infected with Eimeria spp. on pasture. Parasitol Res. 2017 Nov;116(11):2911-2919. doi: 10.1007/s00436-017-5597-5. Epub 2017 Aug 31. PubMed PMID: 28861619.

11: Stock ML, Elazab ST, Hsu WH. Review of triazine antiprotozoal drugs used in veterinary medicine. J Vet Pharmacol Ther. 2018 Apr;41(2):184-194. doi: 10.1111/jvp.12450. Epub 2017 Aug 17. Review. PubMed PMID: 28833212.

12: Abbas A, Iqbal Z, Abbas RZ, Khan MK, Khan JA, Sindhu ZUD, Mahmood MS, Saleemi MK. In vivo anticoccidial effects of Beta vulgaris (sugar beet) in broiler chickens. Microb Pathog. 2017 Oct;111:139-144. doi: 10.1016/j.micpath.2017.07.052. Epub 2017 Aug 18. PubMed PMID: 28826766.

13: da Silva RJ, Gomes AO, Franco PS, Pereira AS, Milian ICB, Ribeiro M, Fiorenzani P, Dos Santos MC, Mineo JR, da Silva NM, Ferro EAV, de Freitas Barbosa B. Enrofloxacin and Toltrazuril Are Able to Reduce Toxoplasma gondii Growth in Human BeWo Trophoblastic Cells and Villous Explants from Human Third Trimester Pregnancy. Front Cell Infect Microbiol. 2017 Jul 26;7:340. doi: 10.3389/fcimb.2017.00340. eCollection 2017. PubMed PMID: 28798905; PubMed Central PMCID: PMC5526852.

14: Shrestha A, Freudenschuss B, Jansen R, Hinney B, Ruttkowski B, Joachim A. Experimentally confirmed toltrazuril resistance in a field isolate of Cystoisospora suis. Parasit Vectors. 2017 Jun 29;10(1):317. doi: 10.1186/s13071-017-2257-7. PubMed PMID: 28662668; PubMed Central PMCID: PMC5492287.

15: Sun W, Pan B. Effect of micro-environment modification and polymer type on the in-vitro dissolution behavior and in-vivo performance of amorphous solid dispersions. Eur J Pharm Sci. 2017 Jun 15;104:240-254. doi: 10.1016/j.ejps.2017.04.007. Epub 2017 Apr 13. PubMed PMID: 28412483.

16: Liu X, Xie S, Ni T, Chen D, Wang X, Pan Y, Wang Y, Huang L, Cheng G, Qu W, Liu Z, Tao Y, Yuan Z. Magnetic solid-phase extraction based on carbon nanotubes for the determination of polyether antibiotic and s-triazine drug residues in animal food with LC-MS/MS. J Sep Sci. 2017 Jun;40(11):2416-2430. doi: 10.1002/jssc.201700017. Epub 2017 May 4. PubMed PMID: 28402029.

17: Barreto F, Ribeiro C, Hoff RB, Costa TD. A simple and high-throughput method for determination and confirmation of 14 coccidiostats in poultry muscle and eggs using liquid chromatography - quadrupole linear ion trap - tandem mass spectrometry (HPLC-QqLIT-MS/MS): Validation according to European Union 2002/657/EC. Talanta. 2017 Jun 1;168:43-51. doi: 10.1016/j.talanta.2017.02.007. Epub 2017 Feb 3. PubMed PMID: 28391864.

18: Mohr F, Betson M, Quintard B. INVESTIGATION OF THE PRESENCE OF ATOXOPLASMA SPP. IN BLUE-CROWNED LAUGHINGTHRUSH (DRYONASTES COURTOISI) ADULTS AND NEONATES. J Zoo Wildl Med. 2017 Mar;48(1):1-6. doi: 10.1638/2016-0044.1. PubMed PMID: 28363058.

19: Lan LH, Sun BB, Zuo BX, Chen XQ, Du AF. Prevalence and drug resistance of avian Eimeria species in broiler chicken farms of Zhejiang province, China. Poult Sci. 2017 Jul 1;96(7):2104-2109. doi: 10.3382/ps/pew499. PubMed PMID: 28339722.

20: Ahn M, Won S, Kang B, Gong P, Yoo E, Dharaneedharan S, Jang Y. In vitro effect of two commercial anti-coccidial drugs against myxospores of Kudoa septempunctata genotype ST3 (Myxozoa, Multivalvulida). Parasite. 2017;24:11. doi: 10.1051/parasite/2017012. Epub 2017 Mar 21. PubMed PMID: 28322722; PubMed Central PMCID: PMC5364777.