Satratoxin H

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461840

CAS#: 53126-64-0

Description: Satratoxin H is an air- and food-borne mycotoxin, which has been implicated in human health damage.

Chemical Structure

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Satratoxin H
CAS# 53126-64-0
Instruction

Theoretical Analysis

MedKoo Cat#: 461840
Name: Satratoxin H
CAS#: 53126-64-0
Chemical Formula: C29H40O9
Exact Mass: 532.27
Molecular Weight: 532.630
Elemental Analysis: C, 65.40; H, 7.57; O, 27.03

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Satratoxin H; Satratoxin-H;

IUPAC/Chemical Name: Spiro(5,9,16,18-dimethano-1H,3H,23H-(1,6,12)trioxacyclooctadecino(3,4-d)(1)benzopyran-17(18H),2'-oxirane)-3,14(9H)-dione, 6,7,16,16a,19a,22-hexahydro-25-hydroxy-9-((1S)-1-hydroxyethyl)-16a,21-dimethyl-, (2'R,4E,9R,10E,12Z,16R,16aS,18R,19aR,23aR,25R)-

InChi Key: NVGMUMDHRHNKKY-ZZTSXYQZSA-N

InChi Code: O=C(OC[C@]1([H])CCO(C)C2=CC[C@@]3([H])[C@@]4(OC4)C12(C)[C@](C3)([H])O5)/C=C([C@@H]6O)\CCC[O@]6([C@H](O)C)/C=C\C=C/C5=O

SMILES Code: O=C(OC[C@]1([H])CCO(C)C2=CC[C@@]3([H])[C@@]4(OC4)C12(C)[C@](C3)([H])O5)/C=C([C@@H]6O)\CCC[O@]6([C@H](O)C)/C=C\C=C/C5=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 532.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nusuetrong P, Saito M, Kikuchi H, Oshima Y, Moriya T, Nakahata N. Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells. J Toxicol Sci. 2012;37(4):803-12. PubMed PMID: 22863859.

2: Nusuetrong P, Pengsuparp T, Meksuriyen D, Tanitsu M, Kikuchi H, Mizugaki M, Shimazu K, Oshima Y, Nakahata N, Yoshida M. Satratoxin H generates reactive oxygen species and lipid peroxides in PC12 cells. Biol Pharm Bull. 2008 Jun;31(6):1115-20. PubMed PMID: 18520041.

3: Gottschalk C, Bauer J, Meyer K. Detection of satratoxin g and h in indoor air from a water-damaged building. Mycopathologia. 2008 Aug;166(2):103-7. doi: 10.1007/s11046-008-9126-z. Epub 2008 Apr 29. PubMed PMID: 18443920.

4: Nusuetrong P, Yoshida M, Tanitsu MA, Kikuchi H, Mizugaki M, Shimazu K, Pengsuparp T, Meksuriyen D, Oshima Y, Nakahata N. Involvement of reactive oxygen species and stress-activated MAPKs in satratoxin H-induced apoptosis. Eur J Pharmacol. 2005 Jan 10;507(1-3):239-46. Epub 2004 Dec 19. PubMed PMID: 15659314.

5: Vojdani A, Thrasher JD, Madison RA, Gray MR, Heuser G, Campbell AW. Antibodies to molds and satratoxin in individuals exposed in water-damaged buildings. Arch Environ Health. 2003 Jul;58(7):421-32. PubMed PMID: 15143855.

6: Glávits R, Ványi A. Effect of trichothecene mycotoxins (satratoxin H and T-2 toxin) on the lymphoid organs of mice. Acta Vet Hung. 1988;36(1-2):37-41. PubMed PMID: 3202049.

7: Eppley RM, Mazzola EP, Highet RJ, Bailey WJ. Structure of satratoxin H, a metabolite of Stachybotrys atra. Application of proton and carbon-13 nuclear magnetic resonance. J Org Chem. 1977 Jan 21;42(2):240-3. PubMed PMID: 556628.

8: Lee MG, Li S, Jarvis BB, Pestka JJ. Effects of satratoxins and other macrocyclic trichothecenes on IL-2 production and viability of EL-4 thymoma cells. J Toxicol Environ Health A. 1999 Aug 13;57(7):459-74. PubMed PMID: 10494915.

9: Harrach B, Mirocha CJ, Pathre SV, Palyusik M. Macrocyclic trichothecene toxins produced by a strain of Stachybotrys atra from Hungary. Appl Environ Microbiol. 1981 Jun;41(6):1428-32. PubMed PMID: 7195684; PubMed Central PMCID: PMC243935.

10: Jarvis BB, Lee YW, Cömezoglu SN, Yatawara CS. Trichothecenes produced by Stachybotrys atra from Eastern Europe. Appl Environ Microbiol. 1986 May;51(5):915-8. PubMed PMID: 3729393; PubMed Central PMCID: PMC238987.

11: Chung YJ, Jarvis B, Pestka J. Modulation of lipopolysaccharide-induced proinflammatory cytokine production by satratoxins and other macrocyclic trichothecenes in the murine macrophage. J Toxicol Environ Health A. 2003 Feb 28;66(4):379-91. PubMed PMID: 12554543.

12: Stack ME, Eppley RM. High pressure liquid chromatographic determination of satratoxins G and H in cereal grains. J Assoc Off Anal Chem. 1980 Nov;63(6):1278-81. PubMed PMID: 7451390.

13: Karunasena E, Larrañaga MD, Simoni JS, Douglas DR, Straus DC. Building-associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment. Mycopathologia. 2010 Dec;170(6):377-90. doi: 10.1007/s11046-010-9330-5. Epub 2010 Jun 13. PubMed PMID: 20549560.

14: Bloom E, Bal K, Nyman E, Must A, Larsson L. Mass spectrometry-based strategy for direct detection and quantification of some mycotoxins produced by Stachybotrys and Aspergillus spp. in indoor environments. Appl Environ Microbiol. 2007 Jul;73(13):4211-7. Epub 2007 May 4. PubMed PMID: 17483261; PubMed Central PMCID: PMC1932766.

15: Usleber E, Dietrich R, Schneider E, Märtlbauer E. [Not Available]. Mycotoxin Res. 2001 Jun;17 Suppl 2:234-7. doi: 10.1007/BF03036443. German. PubMed PMID: 23605879.

16: Smitka TA, Bunge RH, Bloem RJ, French JC. Two new trichothecenes, PD 113,325 and PD 113,326. J Antibiot (Tokyo). 1984 Aug;37(8):823-8. PubMed PMID: 6548218.

17: Sorenson WG, Frazer DG, Jarvis BB, Simpson J, Robinson VA. Trichothecene mycotoxins in aerosolized conidia of Stachybotrys atra. Appl Environ Microbiol. 1987 Jun;53(6):1370-5. PubMed PMID: 3496850; PubMed Central PMCID: PMC203872.

18: Aboul-Nasr MB, Zohri AN, Amer EM. Enzymatic and toxigenic ability of opportunistic fungi contaminating intensive care units and operation rooms at Assiut University Hospitals, Egypt. Springerplus. 2013 Jul 29;2:347. doi: 10.1186/2193-1801-2-347. eCollection 2013. PubMed PMID: 23961411; PubMed Central PMCID: PMC3733072.

19: Harrach B, Nummi M, Niku-Paavola ML, Mirocha CJ, Palyusik M. Identification of "water-soluble" toxins produced by a Stachybotrys atra strain from Finland. Appl Environ Microbiol. 1982 Aug;44(2):494-5. PubMed PMID: 6889838; PubMed Central PMCID: PMC242037.

20: Brasel TL, Douglas DR, Wilson SC, Straus DC. Detection of airborne Stachybotrys chartarum macrocyclic trichothecene mycotoxins on particulates smaller than conidia. Appl Environ Microbiol. 2005 Jan;71(1):114-22. PubMed PMID: 15640178; PubMed Central PMCID: PMC544211.