Kolanone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558563

CAS#: 81827-55-6

Description: Kolanone is a polyisoprenylated benzophenone with antimicrobial properties from Garcinia Kola fruit.

Chemical Structure

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Kolanone
CAS# 81827-55-6
Instruction

Theoretical Analysis

MedKoo Cat#: 558563
Name: Kolanone
CAS#: 81827-55-6
Chemical Formula: C33H42O4
Exact Mass: 502.31
Molecular Weight: 502.690
Elemental Analysis: C, 78.85; H, 8.42; O, 12.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Kolanone;

IUPAC/Chemical Name: 2,5-Cyclohexadien-1-one, 2-benzoyl-4-(3,7-dimethyl-2,6-octadienyl)-3,5-dihydroxy-4,6-bis(3-methyl-2-butenyl)-

InChi Key: FFIYTQGORMJUEB-NCELDCMTSA-N

InChi Code: InChI=1S/C33H42O4/c1-22(2)12-11-13-25(7)19-21-33(20-18-24(5)6)31(36)27(17-16-23(3)4)30(35)28(32(33)37)29(34)26-14-9-8-10-15-26/h8-10,12,14-16,18-19,36-37H,11,13,17,20-21H2,1-7H3/b25-19+

SMILES Code: O=C1C(C(C2=CC=CC=C2)=O)=C(O)C(C/C=C(C)\C)(C/C=C(C)/CC/C=C(C)\C)C(O)=C1C/C=C(C)\C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 502.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. PubMed PMID: 24450891; PubMed Central PMCID: PMC4159618.

2: Rose MA, Green SL, Crilly HM, Kolawole H. Perioperative anaphylaxis grading system: 'making the grade'. Br J Anaesth. 2016 Nov;117(5):551-553. Epub 2016 Aug 29. PubMed PMID: 27574285.

3: Jones MK, Grau KR, Costantini V, Kolawole AO, de Graaf M, Freiden P, Graves CL, Koopmans M, Wallet SM, Tibbetts SA, Schultz-Cherry S, Wobus CE, Vinjé J, Karst SM. Human norovirus culture in B cells. Nat Protoc. 2015 Dec;10(12):1939-47. doi: 10.1038/nprot.2015.121. Epub 2015 Oct 29. PubMed PMID: 26513671; PubMed Central PMCID: PMC4689599.

4: Liu E, Schmidt ME, Margolin R, Sperling R, Koeppe R, Mason NS, Klunk WE, Mathis CA, Salloway S, Fox NC, Hill DL, Les AS, Collins P, Gregg KM, Di J, Lu Y, Tudor IC, Wyman BT, Booth K, Broome S, Yuen E, Grundman M, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials. Neurology. 2015 Aug 25;85(8):692-700. doi: 10.1212/WNL.0000000000001877. Epub 2015 Jul 24. PubMed PMID: 26208959; PubMed Central PMCID: PMC4553028.

5: Abebayehu D, Spence AJ, Qayum AA, Taruselli MT, McLeod JJ, Caslin HL, Chumanevich AP, Kolawole EM, Paranjape A, Baker B, Ndaw VS, Barnstein BO, Oskeritzian CA, Sell SA, Ryan JJ. Lactic Acid Suppresses IL-33-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1α-Dependent miR-155 Suppression. J Immunol. 2016 Oct 1;197(7):2909-17. doi: 10.4049/jimmunol.1600651. Epub 2016 Aug 24. PubMed PMID: 27559047; PubMed Central PMCID: PMC5026940.

6: Kolawole OE, Kola OJ. West Nile virus infection in Ogbomoso: serological evidence. J Immunoassay Immunochem. 2015;36(6):573-8. doi: 10.1080/15321819.2015.1017105. Epub 2015 Feb 25. PubMed PMID: 25714732.

7: Kolawole AO. Catalysis of Silver catfish Major Hepatic Glutathione Transferase proceeds via rapid equilibrium sequential random Mechanism. Toxicol Rep. 2016 Jul 1;3:598-607. doi: 10.1016/j.toxrep.2016.06.006. eCollection 2016. PubMed PMID: 28959583; PubMed Central PMCID: PMC5615938.

8: Zhu Y, Kolawole T, Jimenez XF. Atypical Findings in Massive Bupropion Overdose: A Case Report and Discussion of Psychopharmacologic Issues. J Psychiatr Pract. 2016 Sep;22(5):405-9. doi: 10.1097/PRA.0000000000000179. PubMed PMID: 27648505.

9: Marshall SD, Sanderson P, McIntosh CA, Kolawole H. The effect of two cognitive aid designs on team functioning during intra-operative anaphylaxis emergencies: a multi-centre simulation study. Anaesthesia. 2016 Apr;71(4):389-404. doi: 10.1111/anae.13332. Epub 2016 Jan 21. PubMed PMID: 26792648; PubMed Central PMCID: PMC5066652.

10: Hwang S, Alhatlani B, Arias A, Caddy SL, Christodoulou C, Cunha JB, Emmott E, Gonzalez-Hernandez M, Kolawole A, Lu J, Rippinger C, Sorgeloos F, Thorne L, Vashist S, Goodfellow I, Wobus CE. Murine norovirus: propagation, quantification, and genetic manipulation. Curr Protoc Microbiol. 2014 May 1;33:15K.2.1-61. doi: 10.1002/9780471729259.mc15k02s33. PubMed PMID: 24789596; PubMed Central PMCID: PMC4074558.

11: Kolawole OM, Olatunji KT, Durowade KA. Molecular detection of human papillomavirus from abnormal cervical cytology of women attending a tertiary health facility in Ido-ekiti, southwest Nigeria. J Prev Med Hyg. 2016;57(2):E86-90. Review. PubMed PMID: 27582634; PubMed Central PMCID: PMC4996045.

12: Kolawole O, Ogah J, Alabi O, Suleiman M, Amuda O, Kolawole F. Utilization of Human Papillomavirus DNA Detection for Cervical Cancer Screening in Women Presenting With Abnormal Cytology in Lokoja, Nigeria. Jundishapur J Microbiol. 2015 Oct 20;8(10):e22620. doi: 10.5812/jjm.22620. eCollection 2015 Oct. PubMed PMID: 26568803; PubMed Central PMCID: PMC4640102.

13: Chéron N, Yu C, Kolawole AO, Shakhnovich EI, Wobus CE. Repurposing of rutin for the inhibition of norovirus replication. Arch Virol. 2015 Sep;160(9):2353-8. doi: 10.1007/s00705-015-2495-y. Epub 2015 Jun 26. PubMed PMID: 26112762.

14: Kolawole HM, Jeffrey S. Use of a right-sided double lumen tube for lung isolation in a patient with Kartagener's syndrome. Anaesth Intensive Care. 2016 Jan;44(1):119-21. PubMed PMID: 26673600.

15: Kolawole AO, Rocha-Pereira J, Elftman MD, Neyts J, Wobus CE. Inhibition of human norovirus by a viral polymerase inhibitor in the B cell culture system and in the mouse model. Antiviral Res. 2016 Aug;132:46-9. doi: 10.1016/j.antiviral.2016.05.011. Epub 2016 May 17. PubMed PMID: 27210811; PubMed Central PMCID: PMC4980194.

16: Schulberg EM, Webb AR, Kolawole H. Early skin and challenge testing after rocuronium anaphylaxis. Anaesth Intensive Care. 2016 May;44(3):425-7. PubMed PMID: 27246945.

17: Agodirin SO, Olatoke SA, Rahman GA, Agbakwuru EA, Kolawole OA. ORAL CLINICAL LONG CASE PRESENTATION, THE NEED FOR STANDARDIZATION AND DOCUMENTATION. J West Afr Coll Surg. 2015 Jul-Sep;5(3):49-65. PubMed PMID: 27830133; PubMed Central PMCID: PMC5036266.

18: Kolawole TA, Oyeyemi WA, Adigwe C, Leko B, Udeh C, Dapper DV. Honey Attenuates the Detrimental Effects of Nicotine on Testicular Functions in Nicotine Treated Wistar Rats. Niger J Physiol Sci. 2015 Dec 20;30(1-2):11-6. PubMed PMID: 27507779.

19: Desalu OO, Adeoti AO, Ogunmola OJ, Fadare JO, Kolawole TF. Quality of acute asthma care in two tertiary hospitals in a state in South Western Nigeria: A report of clinical audit. Niger Med J. 2016 Nov-Dec;57(6):339-346. PubMed PMID: 27942102; PubMed Central PMCID: PMC5126747.

20: Suleiman ZA, Wahab KW, Kolawole IK. Opioid prescribing habits of physicians in Kwara State, Nigeria. Ghana Med J. 2016 Jun;50(2):63-7. PubMed PMID: 27635092; PubMed Central PMCID: PMC5012137.