CIM-0216 | CAS#1031496-06-6 | TRPM3 agonist

CIM-0216
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563652

CAS#: 1031496-06-6

Description: CIM-0216 is a selective TRPM3 agonist.

Chemical Structure

CIM-0216

CAS# 1031496-06-6

Instruction

Theoretical Analysis

MedKoo Cat#: 563652
Name: CIM-0216
CAS#: 1031496-06-6
Chemical Formula: C21H21N3O2
Exact Mass: 347.16
Molecular Weight: 347.410
Elemental Analysis: C, 72.60; H, 6.09; N, 12.10; O, 9.21

Price and Availability

Size	Price	Availability
1mg	USD 210	2 Weeks
5mg	USD 385	2 Weeks
10mg	USD 625	2 Weeks
25mg	USD 1000	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: CIM-0216; CIM 0216; CIM0216;

IUPAC/Chemical Name: 3,4-Dihydro-N-(5-methyl-3-isoxazolyl)-a-phenyl-1(2H)-quinolineacetamide

InChi Key: KSEXDSJYVSEVGF-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H21N3O2/c1-15-14-19(23-26-15)22-21(25)20(17-9-3-2-4-10-17)24-13-7-11-16-8-5-6-12-18(16)24/h2-6,8-10,12,14,20H,7,11,13H2,1H3,(H,22,23,25)

SMILES Code: O=C(NC1=NOC(C)=C1)C(C2=CC=CC=C2)N3CCCC4=C3C=CC=C4

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 347.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Held K, Gruss F, Aloi VD, Janssens A, Ulens C, Voets T, Vriens J. Mutations in the voltage-sensing domain affect the alternative ion permeation pathway in the TRPM3 channel. J Physiol. 2018 Jun;596(12):2413-2432. doi: 10.1113/JP274124. Epub 2018 Apr 25. PubMed PMID: 29604058; PubMed Central PMCID: PMC6002228.

2: Badheka D, Yudin Y, Borbiro I, Hartle CM, Yazici A, Mirshahi T, Rohacs T. Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits. Elife. 2017 Aug 15;6. pii: e26147. doi: 10.7554/eLife.26147. PubMed PMID: 28829742; PubMed Central PMCID: PMC5593506.

3: Thiel G, Rubil S, Lesch A, Guethlein LA, Rössler OG. Transient receptor potential TRPM3 channels: Pharmacology, signaling, and biological functions. Pharmacol Res. 2017 Oct;124:92-99. doi: 10.1016/j.phrs.2017.07.014. Epub 2017 Jul 16. Review. PubMed PMID: 28720517.

4: Rubil S, Thiel G. Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels. Channels (Austin). 2017 Jan 2;11(1):79-83. doi: 10.1080/19336950.2016.1207026. Epub 2016 Jun 29. PubMed PMID: 27356187; PubMed Central PMCID: PMC5279878.

5: Held K, Kichko T, De Clercq K, Klaassen H, Van Bree R, Vanherck JC, Marchand A, Reeh PW, Chaltin P, Voets T, Vriens J. Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1363-72. doi: 10.1073/pnas.1419845112. Epub 2015 Mar 2. PubMed PMID: 25733887; PubMed Central PMCID: PMC4371942.

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