RL71

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563644

CAS#: 1195795-93-7

Description: RL71 is a sselective inhibitor of SERCA2, specially binding to SERCA2 at a novel site, suppressing the Ca2+-ATPase activity of SERCA2, inducing apoptosis and downregulating Akt.

Chemical Structure

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RL71
CAS# 1195795-93-7
Instruction

Theoretical Analysis

MedKoo Cat#: 563644
Name: RL71
CAS#: 1195795-93-7
Chemical Formula: C26H31NO7
Exact Mass: 469.21
Molecular Weight: 469.530
Elemental Analysis: C, 66.51; H, 6.66; N, 2.98; O, 23.85

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: RL71; RL-71; RL 71;

IUPAC/Chemical Name: 1-Methyl-3,5-bis-(3,4,5-trimethoxy-benzylidene)-piperidin-4-one

InChi Key: OGEWTDITEXRGCF-GCBPPVMSSA-N

InChi Code: InChI=1S/C26H31NO7/c1-27-14-18(8-16-10-20(29-2)25(33-6)21(11-16)30-3)24(28)19(15-27)9-17-12-22(31-4)26(34-7)23(13-17)32-5/h8-13H,14-15H2,1-7H3/b18-8+,19-9+

SMILES Code: O=C1/C(CN(C)C/C1=C\C2=CC(OC)=C(OC)C(OC)=C2)=C/C3=CC(OC)=C(OC)C(OC)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 469.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Martey O, Nimick M, Taurin S, Sundararajan V, Greish K, Rosengren RJ. Styrene maleic acid-encapsulated RL71 micelles suppress tumor growth in a murine xenograft model of triple negative breast cancer. Int J Nanomedicine. 2017 Oct 4;12:7225-7237. doi: 10.2147/IJN.S148908. eCollection 2017. PubMed PMID: 29042771; PubMed Central PMCID: PMC5634372.

2: Gao J, Fan M, Peng S, Zhang M, Xiang G, Li X, Guo W, Sun Y, Wu X, Wu X, Liang G, Shen Y, Xu Q. Small-molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer. Cell Death Dis. 2017 Sep 14;8(9):e3049. doi: 10.1038/cddis.2017.444. PubMed PMID: 28906486; PubMed Central PMCID: PMC5636988.

3: Yang B, Zhang M, Gao J, Li J, Fan L, Xiang G, Wang X, Wang X, Wu X, Sun Y, Wu X, Liang G, Shen Y, Xu Q. Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer. Oncotarget. 2015 Nov 10;6(35):37613-25. doi: 10.18632/oncotarget.6068. PubMed PMID: 26608678; PubMed Central PMCID: PMC4741952.

4: Taurin S, Nehoff H, Diong J, Larsen L, Rosengren RJ, Greish K. Curcumin-derivative nanomicelles for the treatment of triple negative breast cancer. J Drug Target. 2013 Aug;21(7):675-83. doi: 10.3109/1061186X.2013.796955. Epub 2013 May 16. PubMed PMID: 23679865.

5: Yadav B, Taurin S, Larsen L, Rosengren RJ. RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells. Int J Oncol. 2012 Sep;41(3):1119-27. doi: 10.3892/ijo.2012.1521. Epub 2012 Jun 15. PubMed PMID: 22710975.