IND8

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563640

CAS#: 1778682-59-9

Description: IND8 is a selective and potent α7-nAChR agonist.

Chemical Structure

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IND8
CAS# 1778682-59-9
Instruction

Theoretical Analysis

MedKoo Cat#: 563640
Name: IND8
CAS#: 1778682-59-9
Chemical Formula: C17H19N5
Exact Mass: 293.16
Molecular Weight: 293.370
Elemental Analysis: C, 69.60; H, 6.53; N, 23.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: IND8; IND-8; IND 8;

IUPAC/Chemical Name: 3-(4-(1H-indol-5-yl)-1H-1,2,3-triazol-1-yl)quinuclidine

InChi Key: FBFVECUFQXIPMF-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H19N5/c1-2-15-14(3-6-18-15)9-13(1)16-10-22(20-19-16)17-11-21-7-4-12(17)5-8-21/h1-3,6,9-10,12,17-18H,4-5,7-8,11H2

SMILES Code: C12=C(NC=C2)C=CC(C3=CN(C4CN5CCC4CC5)N=N3)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 293.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Khanduja S, Ghoshal U, Ghoshal UC. Phylogenetic analysis of genetically distinct Enterocytozoon bieneusi infecting renal transplant recipients. Acta Parasitol. 2017 Mar 1;62(1):63-68. doi: 10.1515/ap-2017-0007. PubMed PMID: 28030354.

2: Arunrungvichian K, Boonyarat C, Fokin VV, Taylor P, Vajragupta O. Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors. ACS Chem Neurosci. 2015 Aug 19;6(8):1331-40. doi: 10.1021/acschemneuro.5b00059. Epub 2015 May 15. PubMed PMID: 25978789.

3: Vijayaraghavan P, Prakash Vincent SG. Medium optimization for the production of fibrinolytic enzyme by Paenibacillus sp. IND8 using response surface methodology. ScientificWorldJournal. 2014 Jan 9;2014:276942. doi: 10.1155/2014/276942. eCollection 2014. PubMed PMID: 24523635; PubMed Central PMCID: PMC3913018.

4: Hsieh KH, LaHann TR, Speth RC. Topographic probes of angiotensin and receptor: potent angiotensin II agonist containing diphenylalanine and long-acting antagonists containing biphenylalanine and 2-indan amino acid in position 8. J Med Chem. 1989 Apr;32(4):898-903. PubMed PMID: 2704034.