JL 18

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584496

CAS#: 147395-65-1

Description: JL 18 is a pyridobenzodiazepine derivative bioisoster of clozapine.

Chemical Structure

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JL 18
CAS# 147395-65-1
Instruction

Theoretical Analysis

MedKoo Cat#: 584496
Name: JL 18
CAS#: 147395-65-1
Chemical Formula: C18H21N5
Exact Mass: 307.18
Molecular Weight: 307.401
Elemental Analysis: C, 70.33; H, 6.89; N, 22.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JL 18; JL-18; JL18

IUPAC/Chemical Name: 8-Methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido(2,3-b)(1,4)benzodiazepine

InChi Key: MMCMKWDIEUZMQB-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H21N5/c1-13-5-6-15-14(12-13)18(23-10-8-22(2)9-11-23)21-16-4-3-7-19-17(16)20-15/h3-7,12H,8-11H2,1-2H3,(H,19,20)

SMILES Code: CN1CCN(C2=NC3=CC=CN=C3NC4=CC=C(C)C=C24)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 307.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Shionoya T, Mizuno M, Tsukamoto T, Ikeda K, Seki H, Kojima K, Shibata M, Kawamura I, Sudo Y, Mizutani Y. High Thermal Stability of Oligomeric Assemblies of Thermophilic Rhodopsin in a Lipid Environment. J Phys Chem B. 2018 Jul 12;122(27):6945-6953. doi: 10.1021/acs.jpcb.8b04894. Epub 2018 Jun 27. PubMed PMID: 29893559.

2: Tsukamoto T, Mizutani K, Hasegawa T, Takahashi M, Honda N, Hashimoto N, Shimono K, Yamashita K, Yamamoto M, Miyauchi S, Takagi S, Hayashi S, Murata T, Sudo Y. X-ray Crystallographic Structure of Thermophilic Rhodopsin: IMPLICATIONS FOR HIGH THERMAL STABILITY AND OPTOGENETIC FUNCTION. J Biol Chem. 2016 Jun 3;291(23):12223-32. doi: 10.1074/jbc.M116.719815. Epub 2016 Apr 18. PubMed PMID: 27129243; PubMed Central PMCID: PMC4933271.

3: Murugapiran SK, Huntemann M, Wei CL, Han J, Detter JC, Han C, Erkkila TH, Teshima H, Chen A, Kyrpides N, Mavrommatis K, Markowitz V, Szeto E, Ivanova N, Pagani I, Pati A, Goodwin L, Peters L, Pitluck S, Lam J, McDonald AI, Dodsworth JA, Woyke T, Hedlund BP. Thermus oshimai JL-2 and T. thermophilus JL-18 genome analysis illuminates pathways for carbon, nitrogen, and sulfur cycling. Stand Genomic Sci. 2013 Feb 25;7(3):449-68. doi: 10.4056/sigs.3667269. eCollection 2013. PubMed PMID: 24019992; PubMed Central PMCID: PMC3764938.

4: Murugapiran SK, Huntemann M, Wei CL, Han J, Detter JC, Han CS, Erkkila TH, Teshima H, Chen A, Kyrpides N, Mavrommatis K, Markowitz V, Szeto E, Ivanova N, Pagani I, Lam J, McDonald AI, Dodsworth JA, Pati A, Goodwin L, Peters L, Pitluck S, Woyke T, Hedlund BP. Whole Genome Sequencing of Thermus oshimai JL-2 and Thermus thermophilus JL-18, Incomplete Denitrifiers from the United States Great Basin. Genome Announc. 2013 Jan;1(1). pii: e00106-12. doi: 10.1128/genomeA.00106-12. Epub 2013 Jan 24. PubMed PMID: 23405355; PubMed Central PMCID: PMC3569359.

5: Morishita H, Shibata K, Sakata N, Kita S, Katsuragi T. A new approach to finding specific dopamine D4 receptor agonists. Eur J Pharmacol. 2005 Jun 1;516(2):145-50. PubMed PMID: 15922324.

6: Hadj Tahar A, Bélanger N, Bangassoro E, Grégoire L, Bédard PJ. Antidyskinetic effect of JL-18, a clozapine analog, in parkinsonian monkeys. Eur J Pharmacol. 2000 Jul 7;399(2-3):183-6. PubMed PMID: 10884518.

7: Morishita H, Katsuragi T. Existence and pharmacological properties of dopamine D4 receptors in guinea pig vas deferens. Eur J Pharmacol. 1999 Jun 18;374(2):255-61. PubMed PMID: 10422767.

8: Carey GJ, Bergman J. Discriminative-stimulus effects of clozapine in squirrel monkeys: comparison with conventional and novel antipsychotic drugs. Psychopharmacology (Berl). 1997 Aug;132(3):261-9. PubMed PMID: 9292626.

9: Liégeois JF, Bruhwyler J, Damas J, Rogister F, Masereel B, Geczy J, Delarge J. Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor. Eur J Pharmacol. 1995 Feb 6;273(3):R1-3. PubMed PMID: 7737323.