JL 18

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584496

CAS#: 147395-65-1

Description: JL 18 is a pyridobenzodiazepine derivative bioisoster of clozapine.

Chemical Structure

JL 18
CAS# 147395-65-1

Theoretical Analysis

MedKoo Cat#: 584496
Name: JL 18
CAS#: 147395-65-1
Chemical Formula: C18H21N5
Exact Mass: 307.1797
Molecular Weight: 307.401
Elemental Analysis: C, 70.33; H, 6.89; N, 22.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JL 18; JL-18; JL18

IUPAC/Chemical Name: 8-Methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido(2,3-b)(1,4)benzodiazepine


InChi Code: InChI=1S/C18H21N5/c1-13-5-6-15-14(12-13)18(23-10-8-22(2)9-11-23)21-16-4-3-7-19-17(16)20-15/h3-7,12H,8-11H2,1-2H3,(H,19,20)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 307.401 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shionoya T, Mizuno M, Tsukamoto T, Ikeda K, Seki H, Kojima K, Shibata M, Kawamura I, Sudo Y, Mizutani Y. High Thermal Stability of Oligomeric Assemblies of Thermophilic Rhodopsin in a Lipid Environment. J Phys Chem B. 2018 Jul 12;122(27):6945-6953. doi: 10.1021/acs.jpcb.8b04894. Epub 2018 Jun 27. PubMed PMID: 29893559.

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4: Murugapiran SK, Huntemann M, Wei CL, Han J, Detter JC, Han CS, Erkkila TH, Teshima H, Chen A, Kyrpides N, Mavrommatis K, Markowitz V, Szeto E, Ivanova N, Pagani I, Lam J, McDonald AI, Dodsworth JA, Pati A, Goodwin L, Peters L, Pitluck S, Woyke T, Hedlund BP. Whole Genome Sequencing of Thermus oshimai JL-2 and Thermus thermophilus JL-18, Incomplete Denitrifiers from the United States Great Basin. Genome Announc. 2013 Jan;1(1). pii: e00106-12. doi: 10.1128/genomeA.00106-12. Epub 2013 Jan 24. PubMed PMID: 23405355; PubMed Central PMCID: PMC3569359.

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6: Hadj Tahar A, Bélanger N, Bangassoro E, Grégoire L, Bédard PJ. Antidyskinetic effect of JL-18, a clozapine analog, in parkinsonian monkeys. Eur J Pharmacol. 2000 Jul 7;399(2-3):183-6. PubMed PMID: 10884518.

7: Morishita H, Katsuragi T. Existence and pharmacological properties of dopamine D4 receptors in guinea pig vas deferens. Eur J Pharmacol. 1999 Jun 18;374(2):255-61. PubMed PMID: 10422767.

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9: Liégeois JF, Bruhwyler J, Damas J, Rogister F, Masereel B, Geczy J, Delarge J. Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor. Eur J Pharmacol. 1995 Feb 6;273(3):R1-3. PubMed PMID: 7737323.