Indoprofen | CAS#31842-01-0 | anti-inflammatory

Indoprofen
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461258

CAS#: 31842-01-0

Description: Indoprofen is a non-steroidal anti-inflammatory drug. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market.

Chemical Structure

Indoprofen

CAS# 31842-01-0

Instruction

Theoretical Analysis

MedKoo Cat#: 461258
Name: Indoprofen
CAS#: 31842-01-0
Chemical Formula: C17H15NO3
Exact Mass: 281.11
Molecular Weight: 281.310
Elemental Analysis: C, 72.58; H, 5.37; N, 4.98; O, 17.06

Price and Availability

Size	Price	Availability
50mg	USD 250	2 Weeks
100mg	USD 400	2 Weeks
250mg	USD 650	2 Weeks
1g	USD 950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Indoprofen; Flosint; Isindone; K 4277; K-4277; K4277; Reumofene;

IUPAC/Chemical Name: 2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid

InChi Key: RJMIEHBSYVWVIN-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)

SMILES Code: O=C(O)C(C)C1=CC=C(N(CC2=C3C=CC=C2)C3=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 281.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Trzcionka J, Lhiaubet-Vallet V, Chouini-Lalanne N. DNA photosensitization by indoprofen - is DNA damage photoinduced by indoprofen or by its photoproducts? Photochem Photobiol Sci. 2004 Feb;3(2):226-30. Epub 2003 Nov 20. PubMed PMID: 14872241.

2: Loizzi P, Muratore M, Bruni G, Sacchetti G. A double-blind, crossover comparison between indoprofen and aspirin in rheumatoid arthritis. Curr Med Res Opin. 1980;6(9):598-605. PubMed PMID: 7408527.

3: Innocenti PF, Bruni G, Mandelli V, Ferrati GC. Indoprofen versus ibuprofen in osteoarthrosis: a short-term, double-blind, crossover trial. Curr Med Res Opin. 1979;5(10):793-8. PubMed PMID: 373995.

4: Melander A, Wåhlin-Boll E. Kinetic interaction of glipizide and indoprofen in healthy volunteers. Acta Endocrinol Suppl (Copenh). 1980;239:9-10. PubMed PMID: 6933822.

5: Tamassia V. Human pharmacokinetics of indoprofen. Eur J Rheumatol Inflamm. 1981;4(1):11-5. PubMed PMID: 7341274.

6: Tamassia V, Jannuzzo MG, Moro E, Stegnjaich S, Groppi W, Nicolis FB. Pharmacokinetics of the enantiomers of indoprofen in man. Int J Clin Pharmacol Res. 1984;4(3):223-30. PubMed PMID: 6490241.

7: Siebler D, Kinawi A. [Binding of racemic indoprofen and its enantiomers to human serum albumin]. Arzneimittelforschung. 1989 Jun;39(6):659-60. German. PubMed PMID: 2775332.

8: Persson NH, Bergqvist D, Melander A, Zederfelt B. Comparison of a narcotic (oxicone) and a non-narcotic anti-inflammatory analgesic (indoprofen) in the treatment of renal colic. Acta Chir Scand. 1985;151(2):105-8. PubMed PMID: 3890435.

9: Stygles VG, Commassaris RA, Rech RH, Hook JB. The effect of indoprofen on phenylquinone-writhing and prostaglandin synthesis. Arch Int Pharmacodyn Ther. 1978 Sep;235(1):43-50. PubMed PMID: 736691.

10: Marcolongo R, Lucchese M, Caruso I, Fumagalli M, Bruni G, Sacchetti G. Intravenous indoprofen for prompt relief of acute gout: a regimen-finding study. J Int Med Res. 1980;8(5):326-32. PubMed PMID: 6998792.

11: Kurowski M. Pharmacokinetics of indoprofen in elderly patients following repeated oral administration. Int J Clin Pharmacol Res. 1985;5(4):255-63. PubMed PMID: 4055168.

12: Pedrazzi F, Bommartini F, Freddo J, Emanueli A. A study of the possible interaction of indoprofen with hypoglycemic sulfonylureas in diabetic patients. Eur J Rheumatol Inflamm. 1981;4(1):26-31. PubMed PMID: 7042358.

13: Olstad OA, Skjelbred P. The effects of indoprofen vs paracetamol on swelling, pain and other events after surgery. Int J Clin Pharmacol Ther Toxicol. 1986 Jan;24(1):34-8. PubMed PMID: 3514486.

14: Melander A, Wåhlin-Boll E. Interaction of glipizide and indoprofen. Eur J Rheumatol Inflamm. 1981;4(1):22-5. PubMed PMID: 7341277.

15: Okun R, Green JW, Shackleford RW. An analgesic comparison study of indoprofen versus aspirin and placebo in surgical pain. J Clin Pharmacol. 1979 Aug-Sep;19(8-9 Pt 1):487-92. PubMed PMID: 489767.

16: Buttinoni A, Tommasini R. Preclinical studies on indoprofen, a new non-steroidal analgesic-antiinflammatory agent. Eur J Rheumatol Inflamm. 1981;4(1):3-10. PubMed PMID: 6804240.

17: Huskisson EC, Scott J, Woolf DL. Three trials of indoprofen. Eur J Rheumatol Inflamm. 1981;4(1):97-102. PubMed PMID: 7042369.

18: Torchi B, Villani U, Bruni G, Lavezzari M, Mandelli V. Intravenous indoprofen in the management of renal colic. Int J Clin Pharmacol Res. 1983;3(3):167-73. PubMed PMID: 6384073.

19: Sunshine A, Zighelboim I, Olson NZ, De Sarrazin C, Laska E. A comparative oral analgesic study of indoprofen, aspirin, and placebo in postpartum pain. J Clin Pharmacol. 1985 Jul-Aug;25(5):374-80. PubMed PMID: 3897296.

20: Sartani A, Papatheodossiou N, Parrinello L, Mandelli V. A study of the analgesic potency of indoprofen and pentazocine in postoperative pain. J Clin Pharmacol. 1985 Nov-Dec;25(8):596-600. PubMed PMID: 4078027.

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