Dilazep HCl
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MedKoo CAT#: 598179

CAS#: 20153-98-4

Description: Dilazep HCl is a coronary vasodilator with some antiarrhythmic activity.


Chemical Structure

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Dilazep HCl
CAS# 20153-98-4

Theoretical Analysis

MedKoo Cat#: 598179
Name: Dilazep HCl
CAS#: 20153-98-4
Chemical Formula: C31H46Cl2N2O10
Exact Mass: 676.253
Molecular Weight: 677.613
Elemental Analysis: C, 54.95; H, 6.84; Cl, 10.46; N, 4.13; O, 23.61

Price and Availability

Size Price Availability Quantity
50.0mg USD 550.0 2 Weeks
100.0mg USD 950.0 2 Weeks
200.0mg USD 1650.0 2 Weeks
500.0mg USD 2850.0 2 Weeks
1.0g USD 3650.0 2 Weeks
2.0g USD 5950.0 2 Weeks
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Synonym: Dilazep dihydrochloride; Dilazep HCl; AS 05; ASTA C 4898; K-285; K 285; K285;

IUPAC/Chemical Name: (1,4-diazepane-1,4-diyl)bis(propane-3,1-diyl) bis(3,4,5-trimethoxybenzoate) dihydrochloride

InChi Key: VILIWRRWAWKXRW-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H44N2O10.2ClH/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4;;/h18-21H,7-17H2,1-6H3;2*1H

SMILES Code: O=C(OCCCN1CCN(CCCOC(C2=CC(OC)=C(OC)C(OC)=C2)=O)CCC1)C3=CC(OC)=C(OC)C(OC)=C3.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Product Data:

Biological target: Dilazep dihydrochloride is an inhibitor of adenosine uptake.
In vitro activity: Therefore, these observations may suggest that the suppression of NO synthesis after dilazep treatment in RAW 264 cells is caused by the inhibition of TNF-alpha expression via adenosine receptors. Reference: J Pharmacol Sci. 2010;113(3):271-5. https://pubmed.ncbi.nlm.nih.gov/20647687/
In vivo activity: Dilazep has been reported to inhibit edema formation in cerebral ischemia model of spontaneously hypertensive rats. These results suggest that dilazep prevents the ischemic damage of BBB, which may contribute to reduction of the brain edema. Reference: Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):485-8. https://pubmed.ncbi.nlm.nih.gov/1620248/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Water 100.0 147.58

Preparing Stock Solutions

The following data is based on the product molecular weight 677.613 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 2. Nakatsuka R, Nozaki T, Shinohara M, Ohura K. Dilazep decreases lipopolysaccharide-induced nitric oxide and TNF-alpha synthesis in RAW 264 cells. J Pharmacol Sci. 2010;113(3):271-5. doi: 10.1254/jphs.09286sc. PMID: 20647687.1. Kawagoe J, Abe K, Ikuta J, Igarashi N, Shimizu S, Yamauchi Y, Kogure K. Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):485-8. doi: 10.1007/BF00176629. PMID: 1620248. 3. Zhang Y, Legare DJ, Geiger JD, Lautt WW. Dilazep potentiation of adenosine-mediated superior mesenteric arterial vasodilation. J Pharmacol Exp Ther. 1991 Sep;258(3):767-71. PMID: 1890619.
In vitro protocol: 1. Nakatsuka R, Nozaki T, Shinohara M, Ohura K. Dilazep decreases lipopolysaccharide-induced nitric oxide and TNF-alpha synthesis in RAW 264 cells. J Pharmacol Sci. 2010;113(3):271-5. doi: 10.1254/jphs.09286sc. PMID: 20647687.
In vivo protocol: 1. Kawagoe J, Abe K, Ikuta J, Igarashi N, Shimizu S, Yamauchi Y, Kogure K. Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):485-8. doi: 10.1007/BF00176629. PMID: 1620248. 2. Zhang Y, Legare DJ, Geiger JD, Lautt WW. Dilazep potentiation of adenosine-mediated superior mesenteric arterial vasodilation. J Pharmacol Exp Ther. 1991 Sep;258(3):767-71. PMID: 1890619.

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1: Shida H, Kobayashi M, Chiba S. [Myocardial protection by dilazep in myocardial ischemia and reperfusion]. Arzneimittelforschung. 1981;31(11):1902-6. German. PubMed PMID: 7198472.

2: Shida H, Kobayashi M, Chiba S. Effect of dilazep on myocardial contractility following acute ischemia and reperfusion in isolated blood-perfused canine left ventricular muscle. Jpn Heart J. 1981 Jul;22(4):665-78. PubMed PMID: 6457922.

3: Gero AM. Induction of nucleoside transport sites into the host cell membrane of Babesia bovis infected erythrocytes. Mol Biochem Parasitol. 1989 Jul;35(3):269-76. PubMed PMID: 2747745.