Butalamine | CAS#22131-35-7 | vasodilator

Butalamine
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598166

CAS#: 22131-35-7

Description: Butalamine is a vasodilator (peripheral) with local anesthetic effects. Butalamine has been shown to inhibit state 3 respiration and decrease ADP/O in rat liver.

Chemical Structure

Butalamine

CAS# 22131-35-7

Instruction

Theoretical Analysis

MedKoo Cat#: 598166
Name: Butalamine
CAS#: 22131-35-7
Chemical Formula: C18H28N4O
Exact Mass: 316.23
Molecular Weight: 316.440
Elemental Analysis: C, 68.32; H, 8.92; N, 17.71; O, 5.06

Price and Availability

Size	Price	Availability	Quantity
25mg	USD 330
250mg	USD 1490
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Butalamine; Butalamina;

IUPAC/Chemical Name: N1,N1-dibutyl-N2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethane-1,2-diamine

InChi Key: VYWQZAARVNRSTR-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H28N4O/c1-3-5-13-22(14-6-4-2)15-12-19-18-20-17(21-23-18)16-10-8-7-9-11-16/h7-11H,3-6,12-15H2,1-2H3,(H,19,20,21)

SMILES Code: CCCCN(CCNC1=NC(C2=CC=CC=C2)=NO1)CCCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 316.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tine J, Junien JL. Effects of butalamine on oxydative phosphorylations in the rat liver. Arzneimittelforschung. 1976;26(9):1677-80. PubMed PMID: 826262.

2: Morgon A. [Test of butalamine in labyrinth diseases]. JFORL J Fr Otorhinolaryngol Audiophonol Chir Maxillofac. 1976 May;25(5):395-8. French. PubMed PMID: 133207.

3: Traissac L. [Clinical trial of butalamine]. Rev Laryngol Otol Rhinol (Bord). 1973 Sep-Oct;94(9):465-72. French. PubMed PMID: 4603409.

4: Coupar IM, Hedges A, Metcalfe HL, Turner P. Effect of aminophylline, butalamine and imolamine on human isolated smooth muscle. J Pharm Pharmacol. 1969 Jul;21(7):474-5. PubMed PMID: 4390076.

5: Zeitler E. [Xenon-133 muscle clearance before and after butalamine hydrochloride. Results of a double blind test]. Fortschr Med. 1976 Dec 2;94(34):2055-8. German. PubMed PMID: 826469.

6: Sterne J. [Prolonged treatment of obliterantive arteritis with butalamine. Follow up study of 42 cases during more than 1 year of rheographic control]. Rev Clin Esp. 1979 Oct 31;155(2):123-6. Spanish. PubMed PMID: 119287.

7: Sterne J. [Butalamine hydrochloride. A new vasoactive substance]. Fortschr Med. 1976 Apr 15;94(11):657-9. German. PubMed PMID: 823083.

8: Seboldt H. [Conservative therapy of arterial occlusive diseases. Double-blind study on the effect of butalamine hydrochloride]. Fortschr Med. 1980 Feb 21;98(7):257-60. German. PubMed PMID: 6767648.

9: Zmigrodzka K. [Surheme (Butalamine) in the treatment of vertigo]. Otolaryngol Pol. 1976;30(3):227-33. Polish. PubMed PMID: 823509.

10: Kling H. [Drug therapy of chronic arterial occlusive diseases of the lower extremities with butalamine-HCl]. Fortschr Med. 1979 May 17;97(19):926-8. German. PubMed PMID: 109382.

11: Bopp J. [Therapy of arterial-circulation disorders in the legs. Muscle-ergometric studies under the effects of butalamine hydrochloride in a double-blind trial]. Fortschr Med. 1976 Apr 22;94(12):725-7. German. PubMed PMID: 823084.

12: Belousov IuB, Savenkov PM, Sidel'man AA, Parfenov AS, Savenkov MP. [Pharmacotherapy of peripheral arteriosclerosis]. Kardiologiia. 1978 Aug;18(8):36-43. Russian. PubMed PMID: 99596.

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