Bisphenol B
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592095

CAS#: 77-40-7

Description: Bisphenol B has a binding affinity for estrogen receptors.

Chemical Structure

img
Bisphenol B
CAS# 77-40-7
Instruction

Theoretical Analysis

MedKoo Cat#: 592095
Name: Bisphenol B
CAS#: 77-40-7
Chemical Formula: C16H18O2
Exact Mass: 242.13
Molecular Weight: 242.320
Elemental Analysis: C, 79.31; H, 7.49; O, 13.20

Price and Availability

Size Price Availability Quantity
100mg USD 270 2 weeks
Bulk inquiry

Synonym: Bisphenol B

IUPAC/Chemical Name: 4,4'-(1-Methylpropylidene)bisphenol

InChi Key: HTVITOHKHWFJKO-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H18O2/c1-3-16(2,12-4-8-14(17)9-5-12)13-6-10-15(18)11-7-13/h4-11,17-18H,3H2,1-2H3

SMILES Code: CCC(C1=CC=C(O)C=C1)(C2=CC=C(O)C=C2)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 242.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Ullah A, Pirzada M, Jahan S, Ullah H, Shaheen G, Rehman H, Siddiqui MF, Butt MA. Bisphenol A and its analogs bisphenol B, bisphenol F, and bisphenol S: Comparative in vitro and in vivo studies on the sperms and testicular tissues of rats. Chemosphere. 2018 Jun 19;209:508-516. doi: 10.1016/j.chemosphere.2018.06.089. [Epub ahead of print] PubMed PMID: 29940534.

2: Sun X, Peng J, Wang M, Wang J, Tang C, Yang L, Lei H, Li F, Wang X, Chen J. Determination of nine bisphenols in sewage and sludge using dummy molecularly imprinted solid-phase extraction coupled with liquid chromatography tandem mass spectrometry. J Chromatogr A. 2018 Jun 1;1552:10-16. doi: 10.1016/j.chroma.2018.04.004. Epub 2018 Apr 3. PubMed PMID: 29678407.

3: Dong H, Zeng X, Bai W. Solid phase extraction with high polarity Carb/PSA as composite fillers prior to UPLC-MS/MS to determine six bisphenols and alkylphenols in trace level hotpot seasoning. Food Chem. 2018 Aug 30;258:206-213. doi: 10.1016/j.foodchem.2018.03.074. Epub 2018 Mar 19. PubMed PMID: 29655724.

4: Ikhlas S, Usman A, Ahmad M. Comparative study of the interactions between bisphenol-A and its endocrine disrupting analogues with bovine serum albumin using multi-spectroscopic and molecular docking studies. J Biomol Struct Dyn. 2018 Apr 24:1-11. doi: 10.1080/07391102.2018.1461136. [Epub ahead of print] PubMed PMID: 29620490.

5: Vela N, Calín M, Yáñez-Gascón MJ, Garrido I, Pérez-Lucas G, Fenoll J, Navarro S. Photocatalytic oxidation of six endocrine disruptor chemicals in wastewater using ZnO at pilot plant scale under natural sunlight. Environ Sci Pollut Res Int. 2018 Mar 20. doi: 10.1007/s11356-018-1716-9. [Epub ahead of print] PubMed PMID: 29558788.

6: Russo G, Capuozzo A, Barbato F, Irace C, Santamaria R, Grumetto L. Cytotoxicity of seven bisphenol analogues compared to bisphenol A and relationships with membrane affinity data. Chemosphere. 2018 Jun;201:432-440. doi: 10.1016/j.chemosphere.2018.03.014. Epub 2018 Mar 5. PubMed PMID: 29529570.

7: Xiong L, Yan P, Chu M, Gao YQ, Li WH, Yang XL. A rapid and simple HPLC-FLD screening method with QuEChERS as the sample treatment for the simultaneous monitoring of nine bisphenols in milk. Food Chem. 2018 Apr 1;244:371-377. doi: 10.1016/j.foodchem.2017.10.030. Epub 2017 Oct 10. PubMed PMID: 29120796.

8: Česen M, Lenarčič K, Mislej V, Levstek M, Kovačič A, Cimrmančič B, Uranjek N, Kosjek T, Heath D, Dolenc MS, Heath E. The occurrence and source identification of bisphenol compounds in wastewaters. Sci Total Environ. 2018 Mar;616-617:744-752. doi: 10.1016/j.scitotenv.2017.10.252. Epub 2017 Oct 31. PubMed PMID: 29096955.

9: Okazaki H, Takeda S, Kakizoe K, Taniguchi A, Tokuyasu M, Himeno T, Ishii H, Kohro-Ikeda E, Haraguchi K, Watanabe K, Aramaki H. Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells. Biol Pharm Bull. 2017;40(11):1909-1916. doi: 10.1248/bpb.b17-00427. PubMed PMID: 29093337.

10: Song S, Shao M, Wang W, He Y, Dai X, Wang H, Liu L, Guo F. Development and evaluation of microwave-assisted and ultrasound-assisted methods based on a quick, easy, cheap, effective, rugged, and safe sample preparation approach for the determination of bisphenol analogues in serum and sediments. J Sep Sci. 2017 Dec;40(23):4610-4618. doi: 10.1002/jssc.201700628. Epub 2017 Nov 9. PubMed PMID: 28988464.

11: Cao XL, Popovic S. Solid phase extraction of large volume of water and beverage samples to improve detection limits for GC-MS analysis of bisphenol A and four other bisphenols. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Jan;35(1):49-55. doi: 10.1080/19440049.2017.1382730. Epub 2017 Oct 5. PubMed PMID: 28934011.

12: Yang H, Huang Y, Liu J, Tang P, Sun Q, Xiong X, Tang B, He J, Li H. Binding modes of environmental endocrine disruptors to human serum albumin: insights from STD-NMR, ITC, spectroscopic and molecular docking studies. Sci Rep. 2017 Sep 11;7(1):11126. doi: 10.1038/s41598-017-11604-3. PubMed PMID: 28894220; PubMed Central PMCID: PMC5593971.

13: Xian Y, Wu Y, Dong H, Guo X, Wang B, Wang L. Dispersive micro solid phase extraction (DMSPE) using polymer anion exchange (PAX) as the sorbent followed by UPLC-MS/MS for the rapid determination of four bisphenols in commercial edible oils. J Chromatogr A. 2017 Sep 29;1517:35-43. doi: 10.1016/j.chroma.2017.08.067. Epub 2017 Aug 28. PubMed PMID: 28859891.

14: Cao LY, Ren XM, Li CH, Zhang J, Qin WP, Yang Y, Wan B, Guo LH. Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway. Environ Sci Technol. 2017 Oct 3;51(19):11423-11430. doi: 10.1021/acs.est.7b03336. Epub 2017 Sep 14. PubMed PMID: 28858478.

15: Mesnage R, Phedonos A, Arno M, Balu S, Corton JC, Antoniou MN. Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells. Toxicol Sci. 2017 Aug 1;158(2):431-443. doi: 10.1093/toxsci/kfx101. PubMed PMID: 28591870; PubMed Central PMCID: PMC5837682.

16: Desdoits-Lethimonier C, Lesné L, Gaudriault P, Zalko D, Antignac JP, Deceuninck Y, Platel C, Dejucq-Rainsford N, Mazaud-Guittot S, Jégou B. Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis. Hum Reprod. 2017 Jul 1;32(7):1465-1473. doi: 10.1093/humrep/dex093. PubMed PMID: 28482050.

17: Jurek A, Leitner E. Analytical determination of bisphenol A (BPA) and bisphenol analogues in paper products by GC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 Jul;34(7):1225-1238. doi: 10.1080/19440049.2017.1319076. Epub 2017 May 17. PubMed PMID: 28402180.

18: Lee EH, Lim HJ, Lee SD, Son A. Highly Sensitive Detection of Bisphenol A by NanoAptamer Assay with Truncated Aptamer. ACS Appl Mater Interfaces. 2017 May 3;9(17):14889-14898. doi: 10.1021/acsami.7b02377. Epub 2017 Apr 20. PubMed PMID: 28393521.

19: Gallo P, Di Marco Pisciottano I, Esposito F, Fasano E, Scognamiglio G, Mita GD, Cirillo T. Determination of BPA, BPB, BPF, BADGE and BFDGE in canned energy drinks by molecularly imprinted polymer cleaning up and UPLC with fluorescence detection. Food Chem. 2017 Apr 1;220:406-412. doi: 10.1016/j.foodchem.2016.10.005. Epub 2016 Oct 4. PubMed PMID: 27855918.

20: Gramec Skledar D, Peterlin Mašič L. Bisphenol A and its analogs: Do their metabolites have endocrine activity? Environ Toxicol Pharmacol. 2016 Oct;47:182-199. doi: 10.1016/j.etap.2016.09.014. Epub 2016 Sep 22. Review. PubMed PMID: 27771500.