WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555279

CAS#: 1572510-42-9

Description: JNJ-632 is a potent HVV capsid assembly modulator and HBV replication inhibitor with EC50 of 100-200 nM for genotypes A-D. Administration of JNJ-632 in HBV genotype D infected chimeric mice, resulted in a 2.77 log reduction of the HBV DNA viral load.

Chemical Structure

CAS# 1572510-42-9

Theoretical Analysis

MedKoo Cat#: 555279
Name: JNJ-632
CAS#: 1572510-42-9
Chemical Formula: C18H19FN2O4S
Exact Mass: 378.105
Molecular Weight: 378.4184
Elemental Analysis: C, 57.13; H, 5.06; F, 5.02; N, 7.40; O, 16.91; S, 8.47

Price and Availability

Size Price Availability Quantity
50.0mg USD 450.0 2 Weeks
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 1950.0 2 Weeks
1.0g USD 2950.0 2 Weeks
2.0g USD 5450.0 2 Weeks
5.0g USD 7650.0 2 Weeks
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Synonym: JNJ-632; JNJ 632; JNJ632.

IUPAC/Chemical Name: (S)-N-(4-fluoro-3-methylphenyl)-3-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzamide


InChi Code: InChI=1S/C18H19FN2O4S/c1-12-9-14(5-6-17(12)19)20-18(22)13-3-2-4-16(10-13)26(23,24)21-15-7-8-25-11-15/h2-6,9-10,15,21H,7-8,11H2,1H3,(H,20,22)/t15-/m0/s1

SMILES Code: O=C(NC1=CC=C(F)C(C)=C1)C2=CC=CC(S(=O)(N[C@@H]3COCC3)=O)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 378.4184 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Vandyck K, Rombouts G, Stoops B, Tahri A, Vos A, Verschueren W, Wu Y, Yang J,
Hou F, Huang B, Vergauwen K, Dehertogh P, Berke JM, Raboisson PJMB. Synthesis and
Evaluation of N-phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly
Modulators inhibiting Hepatitis B Virus (HBV). J Med Chem. 2018 Jun 15. doi:
10.1021/acs.jmedchem.8b00654. [Epub ahead of print] PubMed PMID: 29906396.

2: Berke JM, Dehertogh P, Vergauwen K, Van Damme E, Mostmans W, Vandyck K,
Pauwels F. Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary
Human Hepatocytes Infected with Hepatitis B Virus. Antimicrob Agents Chemother.
2017 Jul 25;61(8). pii: e00560-17. doi: 10.1128/AAC.00560-17. Print 2017 Aug.
PubMed PMID: 28584155; PubMed Central PMCID: PMC5527576.


50.0mg / USD 450.0