Glorin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597286

CAS#: 84563-47-3

Description: Glorin is a chemoattractant mediating cell aggregation in the slime mold Polysphondylium violaceum.

Chemical Structure

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Glorin
CAS# 84563-47-3
Instruction

Theoretical Analysis

MedKoo Cat#: 597286
Name: Glorin
CAS#: 84563-47-3
Chemical Formula: C15H25N3O5
Exact Mass: 327.18
Molecular Weight: 327.380
Elemental Analysis: C, 55.03; H, 7.70; N, 12.84; O, 24.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Glorin;

IUPAC/Chemical Name: ethyl N2-((S)-2-oxopiperidin-3-yl)-N2-propionyl-L-glutaminate

InChi Key: RIPAYNTUTNFPLK-QWRGUYRKSA-N

InChi Code: InChI=1S/C15H25N3O5/c1-3-13(20)18(10-6-5-9-17-14(10)21)11(7-8-12(16)19)15(22)23-4-2/h10-11H,3-9H2,1-2H3,(H2,16,19)(H,17,21)/t10-,11-/m0/s1

SMILES Code: O=C(N)CC[C@@H](C(OCC)=O)N([C@@H]1C(NCCC1)=O)C(CC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 327.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Heinrich D, Barnett R, Tweedy L, Insall R, Stallforth P, Winckler T. The Chemoattractant Glorin Is Inactivated by Ester Cleavage during Early Multicellular Development of Polysphondylium pallidum. ACS Chem Biol. 2018 Jun 15;13(6):1506-1513. doi: 10.1021/acschembio.8b00046. Epub 2018 May 24. PubMed PMID: 29792671.

2: Barnett R, Raszkowski D, Winckler T, Stallforth P. Versatile synthesis of the signaling peptide glorin. Beilstein J Org Chem. 2017 Feb 8;13:247-250. doi: 10.3762/bjoc.13.27. eCollection 2017. PubMed PMID: 28326133; PubMed Central PMCID: PMC5331329.

3: Jaiswal P, Singh SP, Aiyar P, Akkali R, Baskar R. Regulation of multiple tip formation by caffeine in cellular slime molds. BMC Dev Biol. 2012 Aug 28;12:26. doi: 10.1186/1471-213X-12-26. PubMed PMID: 22928977; PubMed Central PMCID: PMC3488011.

4: Asghar A, Groth M, Siol O, Gaube F, Enzensperger C, Glöckner G, Winckler T. Developmental gene regulation by an ancient intercellular communication system in social amoebae. Protist. 2012 Jan;163(1):25-37. doi: 10.1016/j.protis.2010.12.002. Epub 2011 Mar 2. PubMed PMID: 21371934.

5: de la Grandmaison GL. Is there progress in the autopsy diagnosis of sudden unexpected death in adults? Forensic Sci Int. 2006 Jan 27;156(2-3):138-44. Review. PubMed PMID: 16410164.

6: de la Grandmaison GL, Carlier R, Chretien F, de Truchis P, Orlikowski D, Gray F. "Burnt out" varicella-zoster-virus encephalitis in an AIDS patient following treatment by highly active antiretroviral therapy. Clin Radiol. 2005 May;60(5):613-7. PubMed PMID: 15851051.

7: Lorin de la Grandmaison G, Paraire F. [Place of pathology in the forensic diagnosis of drowning]. Ann Pathol. 2003 Oct;23(5):400-7. French. PubMed PMID: 14752383.

8: Lorin De La Grandmaison G, Izembart M, Fornes P, Paraire F. Myocarditis associated with Hashimoto's disease: a case report. Int J Legal Med. 2003 Dec;117(6):361-4. Epub 2003 Oct 1. PubMed PMID: 14520579.

9: de la Grandmaison GL, Banasr A, Durigon M. Age estimation using radiographic analysis of laryngeal cartilage. Am J Forensic Med Pathol. 2003 Mar;24(1):96-9. PubMed PMID: 12605008.

10: de la Grandmaison GL, Durigon M. Sudden adult death: a medico-legal series of 77 cases between 1995 and 2000. Med Sci Law. 2002 Jul;42(3):225-32. PubMed PMID: 12201067.

11: de la Grandmaison GL, Durigon M. Pulmonary embolism: a rare cause of sudden infant death. Am J Forensic Med Pathol. 2002 Sep;23(3):257-9. PubMed PMID: 12198352.

12: de la Grandmaison GL, Paraire F. Postmortem revelation of sickle cell disease following fatal episode of acute bronchial asthma. Forensic Sci Int. 2002 Mar 28;126(1):48-52. PubMed PMID: 11955832.

13: Lorin de la Grandmaison G, Paraire F, Onaya M, Gray F. Symmetrical necrosis of the solitary tract nuclei as a contributory cause of death. Int J Legal Med. 2001 Dec;115(3):170-2. PubMed PMID: 11775022.

14: Lorin de la Grandmaison G, Le Bihan C, Durigon M. Assessment of right ventricular lipomatosis by histomorphometry in control adult autopsy cases. Int J Legal Med. 2001 Oct;115(2):105-8. PubMed PMID: 11724427.

15: de la Grandmaison GL, Durigon M. Do medico-legal truths have more power than war lies? About the conflicts in the former Yugoslavia and in Kosovo. Med Sci Law. 2001 Oct;41(4):301-4. PubMed PMID: 11693224.

16: de la Grandmaison GL, Clairand I, Durigon M. Organ weight in 684 adult autopsies: new tables for a Caucasoid population. Forensic Sci Int. 2001 Jun 15;119(2):149-54. PubMed PMID: 11376980.

17: de la Grandmaison GL, Brion F, Durigon M. Frequency of bone lesions: an inadequate criterion for gunshot wound diagnosis in skeletal remains. J Forensic Sci. 2001 May;46(3):593-5. PubMed PMID: 11372994.

18: Kopachik W. Glorin-regulated protein synthesis in Polyspondylium violaceum. Exp Cell Res. 1990 Feb;186(2):394-7. PubMed PMID: 2298250.

19: De Wit RJ, van Bemmelen MX, Penning LC, Pinas JE, Calandra TD, Bonner JT. Studies of cell-surface glorin receptors, glorin degradation, and glorin-induced cellular responses during development of Polysphondylium violaceum. Exp Cell Res. 1988 Dec;179(2):332-43. PubMed PMID: 2847933.

20: Hanna MH, Fatone M, Newth-Clark C, Salerno J, Clemans S. Purification, characterization, and partial structure of D factor from Polysphondylium violaceum. Dev Genet. 1988;9(4-5):653-62. PubMed PMID: 3243039.