Splenotritin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597254

CAS#: 105803-00-7

Description: Splenotritin is an antimicrobial peptide.

Chemical Structure

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Splenotritin
CAS# 105803-00-7
Instruction

Theoretical Analysis

MedKoo Cat#: 597254
Name: Splenotritin
CAS#: 105803-00-7
Chemical Formula: C17H33N7O6
Exact Mass: 431.25
Molecular Weight: 431.490
Elemental Analysis: C, 47.32; H, 7.71; N, 22.72; O, 22.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Splenotritin; Thymopoietin tripeptide; TP-3; TP 3; TP3;

IUPAC/Chemical Name: L-arginyl-L-lysyl-L-glutamic acid

InChi Key: CVXXSWQORBZAAA-SRVKXCTJSA-N

InChi Code: InChI=1S/C17H33N7O6/c18-8-2-1-5-11(15(28)24-12(16(29)30)6-7-13(25)26)23-14(27)10(19)4-3-9-22-17(20)21/h10-12H,1-9,18-19H2,(H,23,27)(H,24,28)(H,25,26)(H,29,30)(H4,20,21,22)/t10-,11-,12-/m0/s1

SMILES Code: O=C(O)CC[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)N)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 431.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Huang HN, Chan YL, Hui CF, Wu JL, Wu CJ, Chen JY. Use of tilapia piscidin 3 (TP3) to protect against MRSA infection in mice with skin injuries. Oncotarget. 2015 May 30;6(15):12955-69. PubMed PMID: 25992774; PubMed Central PMCID: PMC4536991.

2: Onda M, Bruland ØS, Pastan I. TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma. Clin Orthop Relat Res. 2005 Jan;(430):142-8. PubMed PMID: 15662316.

3: Kvinnsland Y, Stokke T, Aurlien E. Radioimmunotherapy with alpha-particle emitters: microdosimetry of cells with a heterogeneous antigen expression and with various diameters of cells and nuclei. Radiat Res. 2001 Feb;155(2):288-96. PubMed PMID: 11175663.

4: Ek O, Waurzyniak B, Myers DE, Uckun FM. Antitumor activity of TP3(anti-p80)-pokeweed antiviral protein immunotoxin in hamster cheek pouch and severe combined immunodeficient mouse xenograft models of human osteosarcoma. Clin Cancer Res. 1998 Jul;4(7):1641-7. PubMed PMID: 9676838.

5: Simon HU, Forner K, Büttner A, Haroske D, Vogt KH. [The lymphocyte transformation test using mononuclear cells of elderly humans as a suitable in vitro method for testing of structure activity relationships of splenin peptides]. Pharmazie. 1990 Dec;45(12):917-9. German. PubMed PMID: 2100799.

6: Dénes L, Hajós G, Szporny L, Szende B, Lapis K, Sipka S, Szegedi G. The effect of thymopoietin 32-34 (TP3) on suramin-induced inhibition on delayed type hypersensitivity in guinea pigs. Immunol Invest. 1987 Jun;16(4):275-9. PubMed PMID: 3323037.

7: Dénes L, Szende B, Hajós G, Szporny L, Lapis K. Therapeutic possibilities of thymopoietin fragments (TP3 and TP4) based on experimental animal models. Drugs Exp Clin Res. 1987;13(5):279-87. PubMed PMID: 3500029.

8: Diezel W, Eckert R, Forner K, Gruner S. Functional effects of splenin32-34 on antibody formation in immunosuppressed mice. Biomed Biochim Acta. 1986;45(10):1349-52. PubMed PMID: 3551932.