Sulfiram | CAS#95-05-6 | ectoparasiticide

Sulfiram
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591718

CAS#: 95-05-6

Description: Sulfiram or monosulfiram, trade name Tetmosol, is an ectoparasiticide used in the treatment and prevention of scabies. It is usually sold as a solution or medicated soap, sometimes in combination with benzyl benzoate.

Chemical Structure

Sulfiram

CAS# 95-05-6

Instruction

Theoretical Analysis

MedKoo Cat#: 591718
Name: Sulfiram
CAS#: 95-05-6
Chemical Formula: C10H20N2S3
Exact Mass: 264.08
Molecular Weight: 264.460
Elemental Analysis: C, 45.42; H, 7.62; N, 10.59; S, 36.37

Price and Availability

Size	Price	Availability	Quantity
250mg	USD 320
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Sulfiram; NSC 36731; NSC-36731; NSC36731

IUPAC/Chemical Name: Sulfide, bis(diethylthiocarbamoyl)

InChi Key: CTPKSRZFJSJGML-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H20N2S3/c1-5-11(6-2)9(13)15-10(14)12(7-3)8-4/h5-8H2,1-4H3

SMILES Code: S=C(SC(N(CC)CC)=S)N(CC)CC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 264.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rezaee E, Goldust M, Alipour H. Treatment of Scabies: Comparison of Lindane 1% vs Permethrin 5. Skinmed. 2015 Aug 1;13(4):283-6. eCollection 2015 Jul-Aug. PubMed PMID: 26861425.

2: Berthe-Aucejo A, Prot-Labarthe S, Pull L, Lorrot M, Touratier S, Trout H, Bourdon O, Dehen L, Bourrat E. [Treatment of scabies and Ascabiol(®) supply disruption: what about the pediatric population?]. Arch Pediatr. 2014 Jun;21(6):670-5. doi: 10.1016/j.arcped.2014.03.001. Epub 2014 Apr 24. French. PubMed PMID: 24768069.

3: Libeu CA, Descamps O, Zhang Q, John V, Bredesen DE. Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS One. 2012;7(6):e40027. doi: 10.1371/journal.pone.0040027. Epub 2012 Jun 29. PubMed PMID: 22768208; PubMed Central PMCID: PMC3386930.

4: Sule HM, Thacher TD. Comparison of ivermectin and benzyl benzoate lotion for scabies in Nigerian patients. Am J Trop Med Hyg. 2007 Feb;76(2):392-5. PubMed PMID: 17297053.

5: Buffet M, Dupin N. Current treatments for scabies. Fundam Clin Pharmacol. 2003 Apr;17(2):217-25. Review. PubMed PMID: 12667233.

6: Diagnosis and treatment of scabies in 2002: rapid diagnosis and proper management limit the risk of spread. Prescrire Int. 2002 Oct;11(61):152-5. PubMed PMID: 12378748.

7: Pitche P, Wolkenstein P, Cremer G, Foulet F, Lascaux AS, Revuz J. [Profuse scabies: kinetic curves of parasitologic cure with an association of benzyl benzoate and sulfiram]. Ann Dermatol Venereol. 2002 Mar;129(3):287-9. French. PubMed PMID: 11988682.

8: Reid JM, Kuffel MJ, Miller JK, Rios R, Ames MM. Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1. Clin Cancer Res. 1999 Aug;5(8):2192-7. PubMed PMID: 10473105.

9: Becagli A, Tagliamento A, Cimarosti P, Costella V, Cecchetti E, Zanatta N, Santonastaso M. [Integrated treatment of alcoholism. Evaluation of its efficacy]. Recenti Prog Med. 1997 Dec;88(12):562-5. Italian. PubMed PMID: 9522596.

10: Mays DC, Nelson AN, Benson LM, Johnson KL, Naylor S, Lipsky JJ. Photolysis of sulfiram: a mechanism for its disulfiram-like reaction. Biochem Pharmacol. 1994 Nov 16;48(10):1917-25. PubMed PMID: 7986203.

11: Lipsky JJ, Mays DC, Naylor S. Monosulfiram, disulfiram, and light. Lancet. 1994 Jan 29;343(8892):304. PubMed PMID: 7905136.

12: Fowler CJ, Brännström G, Ahlgren PC, Florvall L, Akerman KE. Inhibition of inositol 1,4,5-trisphosphate 5-phosphatase by micromolar concentrations of disulfiram and its analogues. Biochem J. 1993 Feb 1;289 ( Pt 3):853-9. PubMed PMID: 8382055; PubMed Central PMCID: PMC1132254.

13: Studdert VP, Hughes KL. A clinical trial of a topical preparation of miconazole, polymyxin and prednisolone in the treatment of otitis externa in dogs. Aust Vet J. 1991 Jun;68(6):193-5. PubMed PMID: 1888310.

14: Reid HF, Thorne CD. Scabies infestation: the effect of intervention by public health education. Epidemiol Infect. 1990 Dec;105(3):595-602. PubMed PMID: 2249723; PubMed Central PMCID: PMC2271813.

15: Burgess I. Adverse reactions to monosulfiram. Lancet. 1990 Oct 6;336(8719):873. PubMed PMID: 1976889.

16: Treating scabies. Drug Ther Bull. 1988 Mar 7;26(5):19-20. Review. PubMed PMID: 2453323.

17: Santos Rde O, Guaraldo AM, Passos LA, Gilioli R, Rangel Hde A. [Use of tetraethylthiuram monosulfide in the treatment of ectoparasites in mice]. Rev Saude Publica. 1988 Feb;22(1):41-5. Portuguese. PubMed PMID: 3217719.

18: Ghate HV. Notochordal anomaly in frog embryos exposed to tetraethylthiuram monosulphide and tetraethylthiuram disulphide. Toxicol Lett. 1983 Dec;19(3):253-9. PubMed PMID: 6658838.

19: Plouvier B, Lemoine X, De Coninck P, Baclet JL, François M. [Antabuse effect during the administration of a topical drug based on monosulfiram]. Nouv Presse Med. 1982 Oct 30;11(43):3209. French. PubMed PMID: 7177842.

20: Dick DC, Adams RH. Allergic contact dermatitis from monosulfiram (Tetmosol)soap. Contact Dermatitis. 1979 May;5(3):199. PubMed PMID: 156623.

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