Glutathione amide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597087

CAS#: 82147-51-1

Description: Glutathione amide is an enzyme, a chimeric protein.

Chemical Structure

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Glutathione amide
CAS# 82147-51-1
Instruction

Theoretical Analysis

MedKoo Cat#: 597087
Name: Glutathione amide
CAS#: 82147-51-1
Chemical Formula: C10H18N4O5S
Exact Mass: 306.10
Molecular Weight: 306.330
Elemental Analysis: C, 39.21; H, 5.92; N, 18.29; O, 26.11; S, 10.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Glutathione amide; GASH cpd; L-gamma-Glutamyl-L-cysteinylglycinamide;

IUPAC/Chemical Name: N5-((R)-1-((2-amino-2-oxoethyl)amino)-3-mercapto-1-oxopropan-2-yl)-L-glutamine

InChi Key: FBCIXVYKFFJYFT-WDSKDSINSA-N

InChi Code: InChI=1S/C10H18N4O5S/c11-5(10(18)19)1-2-8(16)14-6(4-20)9(17)13-3-7(12)15/h5-6,20H,1-4,11H2,(H2,12,15)(H,13,17)(H,14,16)(H,18,19)/t5-,6-/m0/s1

SMILES Code: O=C(N)CNC([C@H](CS)NC(CC[C@@H](C(O)=O)N)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 306.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Van Petegem F, De Vos D, Savvides S, Vergauwen B, Van Beeumen J. Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: crystallographic analysis of a glutathione amide reductase. J Mol Biol. 2007 Dec 7;374(4):883-9. Epub 2007 Sep 29. PubMed PMID: 17977556.

2: Vergauwen B, Pauwels F, Vaneechoutte M, Van Beeumen JJ. Exogenous glutathione completes the defense against oxidative stress in Haemophilus influenzae. J Bacteriol. 2003 Mar;185(5):1572-81. PubMed PMID: 12591874; PubMed Central PMCID: PMC148052.

3: Vergauwen B, Van Petegem F, Remaut H, Pauwels F, Van Beeumen JJ. Crystallization and preliminary X-ray crystallographic analysis of glutathione amide reductase from Chromatium gracile. Acta Crystallogr D Biol Crystallogr. 2002 Feb;58(Pt 2):339-40. Epub 2002 Jan 24. PubMed PMID: 11807270.

4: Fahey RC. Novel thiols of prokaryotes. Annu Rev Microbiol. 2001;55:333-56. Review. PubMed PMID: 11544359.

5: Vergauwen B, Pauwels F, Jacquemotte F, Meyer TE, Cusanovich MA, Bartsch RG, Van Beeumen JJ. Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling. J Biol Chem. 2001 Jun 15;276(24):20890-7. Epub 2001 Apr 3. PubMed PMID: 11399772.

6: Kwon DS, Lin CH, Chen S, Coward JK, Walsh CT, Bollinger JM Jr. Dissection of glutathionylspermidine synthetase/amidase from Escherichia coli into autonomously folding and functional synthetase and amidase domains. J Biol Chem. 1997 Jan 24;272(4):2429-36. PubMed PMID: 8999955.

7: Bartsch RG, Newton GL, Sherrill C, Fahey RC. Glutathione amide and its perthiol in anaerobic sulfur bacteria. J Bacteriol. 1996 Aug;178(15):4742-6. PubMed PMID: 8755912; PubMed Central PMCID: PMC178251.