Sulfaquinoxaline | CAS#59-40-5 | antiprotozoal

Sulfaquinoxaline
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584461

CAS#: 59-40-5

Description: Sulfaquinoxaline is an antiprotozoal agent used to combat coccidial infections of swine, cattle, fowl, and other veterinary animals. Also used in controlling outbreaks of fowl typhoid and fowl cholera and in treatment of infectious enteritis.

Chemical Structure

Sulfaquinoxaline

CAS# 59-40-5

Instruction

Theoretical Analysis

MedKoo Cat#: 584461
Name: Sulfaquinoxaline
CAS#: 59-40-5
Chemical Formula: C14H12N4O2S
Exact Mass: 300.07
Molecular Weight: 300.336
Elemental Analysis: C, 55.99; H, 4.03; N, 18.66; O, 10.65; S, 10.67

Price and Availability

Size	Price	Availability	Quantity
250mg	USD 295
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: AI3-17254; SQ 40; SQX

IUPAC/Chemical Name: Benzenesulfonamide, 4-amino-N-2-quinoxalinyl-

InChi Key: NHZLNPMOSADWGC-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H12N4O2S/c15-10-5-7-11(8-6-10)21(19,20)18-14-9-16-12-3-1-2-4-13(12)17-14/h1-9H,15H2,(H,17,18)

SMILES Code: O=S(C1=CC=C(N)C=C1)(NC2=NC3=CC=CC=C3N=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 300.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Le Fur C, Legeret B, de Sainte Claire P, Wong-Wah-Chung P, Sarakha M. Liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry for the analysis of sulfaquinoxaline byproducts formed in water upon solar light irradiation. Rapid Commun Mass Spectrom. 2013 Mar 30;27(6):722-30. doi: 10.1002/rcm.6507. PubMed PMID: 23418152.

2: Hoff RB, Meneghini L, Pizzolato TM, Peralba Mdo C, Díaz-Cruz MS, Barceló D. Structural elucidation of sulfaquinoxaline metabolism products and their occurrence in biological samples using high-resolution Orbitrap mass spectrometry. Anal Chem. 2014 Jun 3;86(11):5579-86. doi: 10.1021/ac501132r. Epub 2014 May 13. PubMed PMID: 24796379.

3: al-Rashida M, Hussain S, Hamayoun M, Altaf A, Iqbal J. Sulfa drugs as inhibitors of carbonic anhydrase: new targets for the old drugs. Biomed Res Int. 2014;2014:162928. doi: 10.1155/2014/162928. Epub 2014 Sep 8. PubMed PMID: 25538942; PubMed Central PMCID: PMC4241293.

4: Le T, Yan P, Liu J, Wei S. Simultaneous detection of sulfamethazine and sulfaquinoxaline using a dual-label time-resolved fluorescence immunoassay. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(7):1264-9. doi: 10.1080/19440049.2013.801084. Epub 2013 Jun 20. PubMed PMID: 23782396.

5: Daft BM, Bickford AA, Hammarlund MA. Experimental and field sulfaquinoxaline toxicosis in Leghorn chickens. Avian Dis. 1989 Jan-Mar;33(1):30-4. PubMed PMID: 2930405.

6: Zhang Q, Xiao X, Li G. Porous molecularly imprinted monolithic capillary column for on-line extraction coupled to high-performance liquid chromatography for trace analysis of antimicrobials in food samples. Talanta. 2014 Jun;123:63-70. doi: 10.1016/j.talanta.2014.02.010. Epub 2014 Feb 12. PubMed PMID: 24725865.

7: Campbell WC. History of the discovery of sulfaquinoxaline as a coccidiostat. J Parasitol. 2008 Aug;94(4):934-45. doi: 10.1645/GE-1413.1. PubMed PMID: 18837573.

8: Eppel JG, Thiessen JJ. Liquid chromatographic analysis of sulfaquinoxaline and its application to pharmacokinetic studies in rabbits. J Pharm Sci. 1984 Nov;73(11):1635-8. PubMed PMID: 6520769.

9: Piercy DW, Williams RB, White G. Evaluation of a mixture of trimethoprim and sulphaquinoxaline for the treatment of poultry: safety and palatability studies. Vet Rec. 1984 Jan 21;114(3):60-2. PubMed PMID: 6710825.

10: White G, Williams RB. Evaluation of a mixture of trimethoprim and sulphaquinoxaline for the treatment of bacterial and coccidial diseases of poultry. Vet Rec. 1983 Dec 24-31;113(26-27):608-12. PubMed PMID: 6665970.

11: el-Sayed MG, Abd el-Aziz MI, el-Kholy MH. Kinetic behaviour of sulphaquinoxaline and amprolium in chickens. Dtsch Tierarztl Wochenschr. 1995 Dec;102(12):481-5. PubMed PMID: 8591749.

12: Soleymanpour A, Rezvani SA. Development of a novel carbon paste sensor for determination of micromolar amounts of sulfaquinoxaline in pharmaceutical and biological samples. Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:504-9. doi: 10.1016/j.msec.2015.08.034. Epub 2015 Aug 28. PubMed PMID: 26478338.

13: Furusawa N, Tsuzukida Y, Yamaguchi H. Decreasing profile of residual sulphaquinoxaline in eggs. Br Poult Sci. 1998 May;39(2):241-4. PubMed PMID: 9649878.

14: Doretto KM, Peruchi LM, Rath S. Sorption and desorption of sulfadimethoxine, sulfaquinoxaline and sulfamethazine antimicrobials in Brazilian soils. Sci Total Environ. 2014 Apr 1;476-477:406-14. doi: 10.1016/j.scitotenv.2014.01.024. Epub 2014 Jan 30. PubMed PMID: 24486496.

15: Sheridan R, Mirabile J, Hafler K. Determination of six illegal antibiotics in chicken jerky dog treats. J Agric Food Chem. 2014 Apr 30;62(17):3690-6. doi: 10.1021/jf405458m. Epub 2014 Jan 29. PubMed PMID: 24437928.

16: Guo Y, Ngom B, Le T, Jin X, Wang L, Shi D, Wang X, Bi D. Utilizing three monoclonal antibodies in the development of an immunochromatographic assay for simultaneous detection of sulfamethazine, sulfadiazine, and sulfaquinoxaline residues in egg and chicken muscle. Anal Chem. 2010 Sep 15;82(18):7550-5. doi: 10.1021/ac101020y. PubMed PMID: 20726505.

17: Liu C, Wang SJ, Zhang Q, Shao YX. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits. Exp Anim. 2015;64(1):73-9. doi: 10.1538/expanim.14-0064. Epub 2014 Oct 16. PubMed PMID: 25319758; PubMed Central PMCID: PMC4329518.

18: Furusawa N, Tsuzukida Y, Kubota M, Yamaguchi H. Transferring profile of dietary sulphaquinoxaline into eggs. Zentralbl Veterinarmed A. 1998 May;45(4):225-8. PubMed PMID: 9697423.

19: Chapman HD. Chemotherapy of caecal coccidiosis: efficacy of toltrazuril, sulphaquinoxaline/pyrimethamine and amprolium/ethopabate, given in drinking water, against field isolates of Eimeria tenella. Res Vet Sci. 1989 May;46(3):419-20. PubMed PMID: 2740635.

20: Preusch PC, Hazelett SE, Lemasters KK. Sulfaquinoxaline inhibition of vitamin K epoxide and quinone reductase. Arch Biochem Biophys. 1989 Feb 15;269(1):18-24. PubMed PMID: 2916837.

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